Eosinophilic cystitis in a patient with hypereosinophila syndrome: A case report

Jiang, Peng; Wang, Chaojun; Jin, Baiye; Lin, Yiwei; Chen, Shanwen

doi:10.3892/etm.2014.1706

Cited by 5 publications

(15 citation statements)

References 11 publications

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“…Reports of eosinophilic cystitis in dogs and humans are very rare (Fuentealba and Illanes 2000;Evason and Carr 2007;Ozaki et al 2008;Gelberg 2010;Koyima et al 2013;Jiang et al 2014) and to the best of our knowledge the condition has yet to be described in cats. In this case a biopsy of the urinary bladder wall would be necessary to confirm the presumptive diagnosis of eosinophilic cystitis, since eosinophils in FNAB could also represent peripheral eosinophilia and/or eosinophil infiltration in the bladder wall as part of another inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

“…The cause of eosinophilic cystitis remains elusive (Evason and Carr 2007). In humans, eosinophilic cystitis is described as a rare manifestation of hypereosinophilic syndrome, and in most patients, has a benign course with spontaneous resolution (Kojima et al 2013;Jiang et al 2014). In dogs, meanwhile, it is associated with urolithiasis and infections (Fuentealba and Illanes 2000;Evason and Carr 2007); in some cases, the exact cause cannot be determined (Ozaki et al 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Eosinophilic cystitis is a rare manifestation of urinary bladder inflammation with an unascertained aetiology that has only been reported in dogs and humans (Fuentealba and Illanes 2000;Evason anddoi: 10.17221/134/2016-VETMED Carr 2007;Ozaki et al 2008;Gelberg 2010;Koyima et al 2013;Jiang et al 2014).…”

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confidence: 99%

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Recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia and presumptive eosinophilic cystitis in a domestic short-haired cat: a case report

Brložnik¹,

Faraguna²,

Goc³

et al. 2017

Vet. Med. - Czech

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This report describes recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) and eosinophilic cystitis in an 8-year-old domestic short-haired cat. The cat presented with incontinence, pollakiuria, vomiting and weight loss. An abdominal mass was palpated and ultrasonography revealed severe segmental thickening of the jejunal wall with loss of layering. Complete resection of the jejunal mass was performed. The resected mass was composed of branching trabeculae of dense collagen, intermixed with bundles of large fibroblasts and inflammatory cells, which is consistent with FGESF. One year later, a new mass reoccurred in another intestinal segment. Between both FGESF occurrences, mycoplasmas were cultured from urine and fine needle aspiration of the urinary bladder wall showed numerous eosinophils only; therefore, a presumptive diagnosis of eosinophilic cystitis was made. All haematological analyses performed within the one-year period revealed eosinophilia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia and presumptive eosinophilic cystitis in a domestic short-haired cat: a case report

Brložnik¹,

Faraguna²,

Goc³

et al. 2017

Vet. Med. - Czech

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“…In one case series that investigated the incidence of different organs involvement, anemia was present in 53% of patients, thrombocytopenia was more common than thrombocytosis (31% vs. 16%), and bone marrow eosinophilia ranged from 7% to 57% (mean 33%) [11]. Only one case reported eosinophilic cystitis [12].…”

Section: Discussionmentioning

confidence: 99%

Hypereosinophilic Syndrome, Multiorgan Involvement and Response to Imatinib

Hana

Caldera

2020

Cureus

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Hypereosinophilic syndrome (HES) is an uncommon syndrome characterized by peripheral blood eosinophils count of more than 1,500/mm 3 with associated tissue damage. It can be either primary or secondary, for example, due to parasitic infections or inflammation.We present a case of a 49-year-old Asian female with recurrent hospital admissions for cholecystitis, gastritis, urinary cystitis, and pancreatitis. Her peripheral blood count showed excessive eosinophils 15,600-19,000/mm 3 on different occasions. Pathology of her gallbladder and her gastric biopsies showed eosinophilic infiltration. Her bone marrow biopsy showed a normocellular marrow with active trilineage hematopoiesis, eosinophilia, mild megakaryocytic hyperplasia with a few atypical forms, and mild T-cell lymphocytosis. Flow cytometry showed no evidence of acute leukemia, or T-cell or B-cell lymphoproliferative disorder. On fluorescent in-situ hybridization (FISH), myeloproliferative neoplasms (MPN) testing was negative for platelet-derived growth factor receptor-alpha (PDGFRA), platelet-derived growth factor receptor-beta (PDGFRB), and fibroblast growth factor receptor-1 (FGFR1) rearrangement. Despite not having the FIP1L1-PDGFRA (factor interacting with PAPOLA and CPSF1-plateletderived growth factor receptor, alpha polypeptide) gene fusion, our patient responded to the treatment with a significant decrease in her absolute eosinophils count and resolution of her symptoms.

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“…Cases have also been reported in association with idiopathic hypereosinophilic syndrome, such as observed in the present case. 13,14 Peripheral eosinophilia is detected in about 40% of cases. Radiologic testing by intravenous urography, ultrasonography, or CT scan often detects bladder wall thickening or solitary tumor-like lesions that can mimic bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

BRAFmutation as a novel driver of eosinophilic cystitis

Choi

Tsigelny

Boichard

et al. 2017

Cancer Biology & Therapy

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Eosinophilic cystitis is a rare manifestation of hypereosinophilia and a cause of morbidity, including dysuria and hematuria. Although some cases can be attributed to infection or allergy, most cases are assessed to be idiopathic and treated with corticosteroids. However, hypereosinophilia can also be due to actionable clonal molecular alterations in the haematopoietic cells, similar to other myeloproliferative neoplasms. Common mutations associated with eosonophilic syndromes are of platelet-derived growth factor receptor α or β or c-kit, though other pathogenic mutations have been found by next generation sequencing. Determination of a specific mutation may therefore identify clonality and refine treatment of some cases. Here we review the molecular features of eosinophilic disorders. We also describe the use of a liquid biopsy of circulating cell-free DNA in the workup of a case of eosinophilic cystitis in which next generation sequencing of cell-free DNA showed a BRAF I463T mutation. In silico modeling supports the functional impact and potential clinical relevance of BRAF I463T.

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Eosinophilic cystitis in a patient with hypereosinophila syndrome: A case report

Cited by 5 publications

References 11 publications

Recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia and presumptive eosinophilic cystitis in a domestic short-haired cat: a case report

Recurrent feline gastrointestinal eosinophilic sclerosing fibroplasia and presumptive eosinophilic cystitis in a domestic short-haired cat: a case report

Hypereosinophilic Syndrome, Multiorgan Involvement and Response to Imatinib

BRAFmutation as a novel driver of eosinophilic cystitis

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