<i>BRAF</i>mutation as a novel driver of eosinophilic cystitis

Choi, Michael Y.; Tsigelny, Igor F.; Boichard, Amélie; Skjevik, Åge A.; Shabaik, Ahmed; Kurzrock, Razelle

doi:10.1080/15384047.2017.1360449

Cited by 5 publications

(4 citation statements)

References 32 publications

(36 reference statements)

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“…[ 7 ] It has also been reported that it may be related to the mutation of BRAF 1463T gene. [ 8 , 9 ] This case has no history of allergy and bladder surgery, except prostate hyperplasia and urinary tract infection.…”

Section: Discussionmentioning

confidence: 99%

Misdiagnosis of eosinophilic cystitis: A case report and literature review

Shi,

Wang,

Peng

et al. 2024

Medicine

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Rationale: Eosinophilic cystitis (EC) is a rare and specific transmural inflammatory disease in clinic. At present, its etiology is unknown, its clinical manifestations are diverse, and its auxiliary examination lacks specificity, so it is easy to be missed or misdiagnosed in clinical practice. Patient concerns: A 72-year-old male patient with symptoms of lower urinary tract obstruction accompanied by hematuria was diagnosed with benign prostatic hyperplasia with bleeding by B-ultrasound and urinary CT examination. After being treated with catheterization, anti-infection and hemostasis, he was selectively treated with transurethral resection of prostate, but he saw a pattern mass on the right back wall of the bladder during the operation. Considering bladder tumor, he removed the lesion and gave pirarubicin for bladder perfusion. However, the postoperative pathological result was EC. Diagnosis: The diagnosis of EC can only rely on pathological examination, and the accurate and positive rate of biopsy can be improved by obtaining muscle tissue as much as possible at the same time of multi-point biopsy. Intervention: Prednisone and cetirizine were given orally after transurethral resection of lesions, and tamsulosin and finasteride were given regularly to treat benign prostatic hyperplasia. Outcomes: No recurrence and abnormal urination were found during the follow-up for half a year, and the upper urinary tract function was normal. Lessons: The clinical manifestations of EC are atypical, the laboratory examination and imaging examination are not specific, and it is difficult to make a definite diagnosis before operation. The diagnosis depends on pathological examination. Transurethral resection of the lesion can obviously improve the positive rate of biopsy while completely removing the lesion, and the combined drug treatment can achieve satisfactory results in a short period of time. Active follow-up after operation is very important to identify the recurrence of the disease and prevent the upper urinary tract function from being damaged.

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Section: Discussionmentioning

confidence: 99%

Misdiagnosis of eosinophilic cystitis: A case report and literature review

Shi,

Wang,

Peng

et al. 2024

Medicine

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“…Among the 135 cases, the age of EC patients ranged from 5 to 87 years old, with an average age of 41.6 years old and no gender difference [ 2 ]. EC is thought to be associated with BRAFI463T gene mutation [ 3 ], which may lead to molecular defects of haematopoietic stem cells or myeloid cell. Sanaphylaxis caused by a variety of physical, chemical, biological and pathological factors is involved in the pathogenesis of EC, one-third of case’s cause still not found [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic cystitis complicated with cystitis glandularis: a case report

Chen

Zeng

et al. 2022

BMC Urol

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Background Eosinophilic cystitis (EC) is a rare inflammatory disease characterized by the gathering and infiltration of numerous eosinophilia (EOS) in the bladder wall. Because of Few cases of EC have been reported globally, the epidemiology of EC is not well known. We report herein the details of one very scarce case of large tumor-like eosinophilic cystitis complicated with cystitis glandularis (CG) diagnosed by biopsy. Case presentation A 45-year-old Chinese man was referred to our hospital for the treatment of right lumbago and odynuria. Ultrasound examination indicated the low echo on the right portion wall and the neck of the bladder. Computed tomography showed a remarkable enhancing large mass that measured 5.0 cm × 2.3 cm located on the right portion of the bladder with undefined margin. For further treatment, diagnostic transurethral resection of the bladder was performed, the postoperative histopathological diagnosis was EC complicated with CG. After transurethral resection, antibiotics, glucocorticoids, and antihistamines were treated. The patient recovered uneventfully and was discharged on postoperative day 8 without evidence of recurrence followed-up for 6 months. Conclusion Large tumor-like eosinophilic cystitis complicated with cystitis glandularis is rare, malignant tumors need to be ruled out. We deem that prompt biopsy led to the exact diagnosis, appropriate treatment led to better prognosis.

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“…Eosinophilic cystitis is a rare inflammatory disorder characterized by eosinophilic infiltration of entire layers of the bladder wall (van den Ouden, 2000). The condition has been described in adults, children, and dogs (Abilov et al, 2013;Choi et al, 2017;Evason & Carr, 2007). The most common clinical signs of eosinophilic cystitis reported in the literature include pollakiuria, dysuria, haematuria, suprapubic pain, or urinary retention that mimic other inflammatory conditions (He et al, 2018;van den Ouden, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…The cause and pathogenesis of the disease remain unclear (Choi et al, 2017). It is speculated that an antigenantibody complex is formed on exposure to antigens in the bladder.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic cystitis, a rare cause of persistent haematuria in a diabetic dog

Braz

Cruz

Santos

et al. 2021

Braz. J. Vet. Res. Anim. Sci.

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A cistite eosinofílica é uma doença inflamatória rara caracterizada por infiltração eosinofílica de todas as camadas da parede da bexiga. Essa enfermidade já foi descrita em adultos, crianças e cães. No entanto, não há um consenso de diretrizes sobre o seu tratamento. Mesmo que as literaturas humana e veterinária mostrem alguma eficácia no manejo com corticosteroides, anti-histamínicos e antibióticos, uma variedade de efeitos colaterais graves e frequentes estão associados à terapia com esteróides. Dessa forma, seu uso é relativamente contra-indicado para pacientes com diabetes mellitus e síndrome de Cushing, por exemplo. Um chow-chow, macho, castrado, de cinco anos e diabético estável foi encaminhado para atendimento com histórico de urina fétida, hematúria macroscópica e disúria não responsiva a antibióticos há 18 meses. A avaliação dos parâmetros físicos estava dentro dos padrões, exceto por desconforto abdominal suprapúbico. O hemograma e o perfil bioquímico estavam dentro dos valores de referência, exceto por eosinofilia periférica leve. Embora a ultrassonografia, a radiografia contratada da bexiga e os achados da urinálise indicassem malignidade, a histopatologia confirmou o diagnóstico definitivo de cistite eosinofílica. O manejo com ciclosporina foi satisfatório, com remissão completa da hematúria. Este relato de caso apresenta o primeiro uso documentado de ciclosporina para o tratamento de cistite eosinofílica, com sucesso, em um cão com diabetes.

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BRAFmutation as a novel driver of eosinophilic cystitis

Cited by 5 publications

References 32 publications

Misdiagnosis of eosinophilic cystitis: A case report and literature review

Misdiagnosis of eosinophilic cystitis: A case report and literature review

Eosinophilic cystitis complicated with cystitis glandularis: a case report

Eosinophilic cystitis, a rare cause of persistent haematuria in a diabetic dog

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