Hypereosinophilic syndrome associated with multiple coronary aneurysms

Puri, Rishi; Dundon, Benjamin K.; Leong, Darryl P.; Khurana, Suchi; Worthley, M.

doi:10.1016/j.ijcard.2007.08.136

Cited by 16 publications

(13 citation statements)

References 5 publications

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“…Furthermore, eosinophilic vasculitis with medial necrosis has been identified at autopsy in otherwise healthy individuals with spontaneous coronary dissection or rupture. It has therefore been proposed that cytotoxic substances released from perivascular eosinophils may result in direct medial destruction, predisposing to aneurysmal formation or spontaneous intimal dissection and sudden cardiac death [30].…”

Section: Discussionmentioning

confidence: 99%

A review on the vascular features of the hyperimmunoglobulin E syndrome

Yavûz

Chee

2009

Clinical and Experimental Immunology

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SummaryAutosomal recessive, autosomal dominant and the sporadic forms of hyperimmunoglobulin E syndrome (HIES) are multi-system disorders. Although HIES patients may present with cold abscesses, the vascular features of HIES are not well recognized. The objective of this review is to characterize the nature and spectrum of vascular abnormalities in HIES patients. Vascular abnormalities in HIES patients were reviewed with Medline and Google Scholar-based searches. In brief, the searches combined terms related to HIES with the terms related to vasculature. Furthermore, reference lists from the original studies and review papers identified were screened. There were vascular abnormalities in 25 patients with HIES. These abnormalities were identified as aneurysms (coronary, aortic, carotid and cerebral), pseudoaneurysms, congenital patent ductus venosus, superior vena cava syndrome, vasculitides, vascular ectasia, thrombosis and others. They may be congenital or acquired, in the veins and arteries, affecting both sexes. These abnormalities can be seen in all subtypes of HIES. They could be also fatal in children and adults. Limited pathological investigations revealed the presence of vasculitis. Three of the patients were found to have overlap diseases. In this review, the spectrum of vascular abnormalities in HIES are documented and discussed in detail for the first time. They highlight a previously under-recognized and potentially devastating complication of these disorders. These vascular abnormalities constitute one of the major clinical characteristics in HIES. The presence of hypereosinophilia, vasculitis and defective angiogenesis in HIES may contribute to the formation of vascular abnormalities in HIES.

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Section: Discussionmentioning

confidence: 99%

A review on the vascular features of the hyperimmunoglobulin E syndrome

Yavûz

Chee

2009

Clinical and Experimental Immunology

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“…The release of this protein may damage collagen, elastin and smooth muscle cells. This damage predisposes to aneurysm formation or spontaneous intimal dissection of coronary arteries and can lead to cardiac emboli or sudden cardiac death [10, 11]. A similar mechanism may play a role in intracranial dissection, as in our patient.…”

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confidence: 70%

Dissection of the posterior inferior cerebellar artery in the hypereosinophilic syndrome

et al. 2011

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“…It has therefore been proposed that cytotoxic substances released from perivascular eosinophils may result in direct medial destruction, predisposing to aneurysmal formation or spontaneous intimal dissection and sudden cardiac death [25]. …”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Plasma Eosinophil Count and Coronary Artery Ectasia

2013

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BackgroundThe pathophysiology of coronary artery ectasia (CAE) has not been clearly identified, although multiple abnormalities including arteritis, endothelial dysfunction, and atherothrombosis have been reported. It is known that eosinophils play an important role in inflammation and thrombosis. Also vascular anomalies such as aneurysm have been noted in patients with hypereosinophilic syndromes. We aimed to compare the numbers of eosinophil counts of the patients CAE versus controls.MethodsThis study included 50 CAE patients (20 male, mean age 60.26 ± 10.6 years) and 30 control person (10 male, mean age 57.86 ± 11.6 years). These participants were performed concurrent routine biochemical tests and neutrophil, lymphocyte, eosinophil count and mean platelet volume (MPV) on whole blood count. These parameters were compared between groups.ResultsBaseline characteristics of the study groups were comparable. CAE patients had a higher MPV value, eosinophil, neutrophil lymphocyte ratio (NLR) than controls (8.5 ± 1 vs 76.2 ± 1.6 fl and 0.198 ± 0.14 vs 0.093 ± 0.058 and 3.0 ± 2.5vs 1.14 ± 0.9; P < 0.001, 0.002 and 0.028 respectively).ConclusionAs a result, our study revealed a relationship between eosinophil count, NLR and MPV in patients with CAE.

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Hypereosinophilic syndrome associated with multiple coronary aneurysms

Cited by 16 publications

References 5 publications

A review on the vascular features of the hyperimmunoglobulin E syndrome

A review on the vascular features of the hyperimmunoglobulin E syndrome

Dissection of the posterior inferior cerebellar artery in the hypereosinophilic syndrome

The Relationship Between Plasma Eosinophil Count and Coronary Artery Ectasia

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