The Relationship Between Plasma Eosinophil Count and Coronary Artery Ectasia

Abstract

BackgroundThe pathophysiology of coronary artery ectasia (CAE) has not been clearly identified, although multiple abnormalities including arteritis, endothelial dysfunction, and atherothrombosis have been reported. It is known that eosinophils play an important role in inflammation and thrombosis. Also vascular anomalies such as aneurysm have been noted in patients with hypereosinophilic syndromes. We aimed to compare the numbers of eosinophil counts of the patients CAE versus controls.MethodsThis study included 50 CAE patients (20 male, mean age 60.26 ± 10.6 years) and 30 control person (10 male, mean age 57.86 ± 11.6 years). These participants were performed concurrent routine biochemical tests and neutrophil, lymphocyte, eosinophil count and mean platelet volume (MPV) on whole blood count. These parameters were compared between groups.ResultsBaseline characteristics of the study groups were comparable. CAE patients had a higher MPV value, eosinophil, neutrophil lymphocyte ratio (NLR) than controls (8.5 ± 1 vs 76.2 ± 1.6 fl and 0.198 ± 0.14 vs 0.093 ± 0.058 and 3.0 ± 2.5vs 1.14 ± 0.9; P < 0.001, 0.002 and 0.028 respectively).ConclusionAs a result, our study revealed a relationship between eosinophil count, NLR and MPV in patients with CAE.

New inflammatory indicators: association of high eosinophil-to-lymphocyte ratio and low lymphocyte-to-monocyte ratio with smoking

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“…Both high monocyte, eosinophil, and neutrophil counts and a low lymphocyte count reflect systemic inflammation and physiologic stress and contribute to the development of cardiovascular disease. [28][29][30][31][32][33] The relationships between the LMR, ELR, and NLR and adverse events in patients with oncological and cardiac diseases have been revealed in several recent studies. The NLR, ELR, and LMR, which are easily calculated from the CBC count, have been shown to be potential diagnostic and prognostic indicators of some malignant subtypes and cardiac diseases.…”

Comparison of mean platelet volume levels in coronary artery ectasia and healthy people: systematic review and meta-analysis

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