Hyperemesis-induced Wernicke-Korsakoff Syndrome due to Hypergastrinemia during Long-term Treatment with Proton Pump Inhibitors

Abstract

We herein report a patient with Wernicke-Korsakoff syndrome (WKS) who had neither a history of alcoholism or of history of gastric surgery. A 56-year-old woman was transferred to our hospital because of the loss of consciousness and she was diagnosed to have Wernicke encephalopathy. She showed proton pump inhibitor-induced refractory hypergastrinemia with the subsequent development of hyperemesis and a vitamin B1 deficiency.

Identifying, Assessing, and Treating Korsakoff Syndrome Patients

“…• Localized brain lesions due to vascular (Rahme et al, 2007), neoplastic (de Falco et al, 2018, and traumatic lesions (Brion et al, 2001;Kahn and Crosby, 1972); • Malnutrition associated with general cachexia from starvation (DeWardener and Lennox, 1947), pellagra and thiamine deficiency beriberi (Di Marco et al, 2018), and psychogenic food refusal (Hargrave et al, 2015); • Gastrointestinal malabsorption and fluid problems due to gastric bypass and gastrointestinal malfunction (Fandiño et al, 2005), celiac disease (Sahu et al, 2020), excessive protein pump treatment (Miyanaga et al, 2020), and hyperemesis gravidarum (Ashraf et al, 2016); and • Cancer with low serum thiamine, low oral intake, weight loss, and gastrointestinal and hematologic malignancies (Isenberg-Grzeda et al, 2016).…”

“…Gastrointestinal malabsorption and fluid problems due to gastric bypass and gastrointestinal malfunction (Fandiño et al, 2005), celiac disease (Sahu et al, 2020), excessive protein pump treatment (Miyanaga et al, 2020), and hyperemesis gravidarum (Ashraf et al, 2016); and…”