Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses

Zhu, Ziqing; Wang, You; Lau, Way Kwok‐Wai; Wei, Xinhua; Liu, Yingjun; Huang, Ruiwang; Zhang, Ruibin

doi:10.1007/s11682-022-00628-7

Cited by 25 publications

(10 citation statements)

References 82 publications

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“…Several previous studies have demonstrated structural as well as functional alterations in the left MFG in adolescents with MDD ( 13 , 46 – 48 ). The MFG is involved in regulating the default mode network activity via an antagonistic relationship, and in addition, it constitutes a core portion of the dorsolateral prefrontal cortex (DLPFC), which is the main hub of the central executive network responsible for executive and cognitive control such as response inhibition and working memory ( 49 ). By contrast, Wang et al ( 50 ) enrolled 30 adolescents with MDD and found that patients showed elevated fALFF in the left MFG relative to HCs at baseline, and that fALFF values increased further after electroconvulsive therapy.…”

Section: Discussionmentioning

confidence: 99%

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Liu

Huang

et al. 2022

Front. Psychiatry

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BackgroundThe neurobiological basis of suicidal behaviors among female adolescents with major depressive disorder (MDD) remains largely unclear.Materials and methodsFifty-eight drug-naïve, first-episode female adolescent MDD [including 31 patients with suicidal attempt (SA group) and 27 patients without SA (non-SA group)], and 36 matched healthy controls (HCs) participated in the present study. Resting-state functional magnetic resonance imaging (MRI) was performed on each subject. The metrics of the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared among the three groups. Then seed-based functional connectivity (FC) was conducted based on the ALFF/fALFF and ReHo results, which were then correlated to clinical variables.ResultsCompared with the non-SA group, the SA group exhibited increased fALFF in the bilateral insula and right precentral gyrus, and enhanced ReHo in the left superior temporal gyrus, left middle cingulate cortex, right insula, and right precentral gyrus. Relative to the HCs, the SA group demonstrated additionally reduced fALFF and ReHo in the left middle frontal gyrus. Moreover, the SA group showed increased FC between the right precentral gyrus and the left middle frontal gyrus and left insula, and between the right insula and anterior/middle cingulate cortex compared to the non-SA and HC groups. In addition, the fALFF in the left middle frontal gyrus was positively correlated with the 17-item Hamilton Depression Rating Scale scores, and the values in the fALFF/ReHo in the right insula were positively correlated with the duration of MDD within the patient group.ConclusionThese findings highlight the multiple abnormalities of the frontolimbic circuit, which may enhance our understanding of the neurobiological basis underlying female MDD with SA during adolescence.

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Section: Discussionmentioning

confidence: 99%

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Liu

Huang

et al. 2022

Front. Psychiatry

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“…Relative to healthy controls, melancholic patients also displayed decreased VMHC in the PCC ( 49 ). However, a recent meta-analysis MDD of the PCC showed higher FC in the bilateral MTG ( 47 ). The inconsistencies in these research results may have been caused by the different sample sizes, analysis methods, and software used, and the lack of a guarantee of complete homogeneity in the subjects selected.…”

Section: Discussionmentioning

confidence: 96%

“…The CG has been an important role subject of focus in previous pathological studies of depression, and the signs seen during the pathogenesis of depression are different between the anterior CG and posterior CG. The anterior CG is mainly related to self-control and emotional control, while the posterior CG is primarily related to early awakening, introspection, memory, and thought flexibility ( 47 ). Differences in the signs of depression between the two may be related to the core brain regions of the posterior CG involved in the default network.…”

Section: Discussionmentioning

confidence: 99%

Vortioxetine Modulates the Regional Signal in First-Episode Drug-Free Major Depressive Disorder at Rest

Xiong

Li²,

Zhou³

et al. 2022

Front. Psychiatry

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BackgroundPrevious studies on brain functional alterations associated with antidepressants for major depressive disorder (MDD) have produced conflicting results because they involved short treatment periods and a variety of compounds.MethodsResting-state functional magnetic resonance imaging scans were obtained from 25 first-episode drug-free patients with MDD and 25 healthy controls. The patients, who were treated with vortioxetine for 8 weeks, were scanned at two-time points (baseline and week 8 of treatment). The amplitude of low-frequency fluctuation (ALFF) in the imaging data was used to analyze local brain signal alterations associated with antidepressant treatment.ResultsCompared with the controls, the patients at baseline showed decreased ALFF values in the right inferior temporal gyrus and increased ALFF values in the left inferior cerebellum, right cingulate gyrus and postcentral gyrus. After 8 weeks of vortioxetine treatment, patients showed increased ALFF values in the bilateral cingulate gyrus, middle temporal gyrus, medial superior frontal gyrus, and inferior cerebellum.ConclusionThis study provided evidence that vortioxetine modulates brain signals in MDD sufferers. These findings contribute to the understanding of how antidepressants effect brain function.

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“…For example, Zhang et al (2021) found significantly increased ALFF values in the left MFG in depression subjects. Zhu et al (2022) reported a negative association between the changed FC of the MFG and the severity of depression. Che et al (2020) reported that fALFF values of the left MFG were significantly increased in the peripartum depression group.…”

Section: Discussionmentioning

confidence: 99%

“…For example, increased anterior cingulate-inferior frontal gyrus connectivity has been reported by Rolls et al (2019) . Zhu et al (2022) reported that the posterior cingulate showed higher resting-state functional connectivity with the right middle frontal gyrus (MFG) and the left middle temporal gyrus (MTG) in depressive patients. In addition, our correlation analysis showed that FC values were negatively correlated with patients’ SDS scores.…”

Section: Discussionmentioning

confidence: 99%

Abnormal functional connectivity in psoriasis patients with depression is associated with their clinical symptoms

Wang

Liu

et al. 2022

Front. Neurosci.

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Psoriasis is a chronic, autoimmune disorder that is related to mental health disorders such as depression. However, few studies have focused on the features of brain activity in psoriasis patients with depression (PPD) and the association between brain activity and disease severity. A total of 29 PPD and 24 healthy controls were involved in this study, and all participants underwent resting-state functional magnetic resonance imaging (fMRI) scanning. The psoriasis area and severity index (PASI) and the self-rating depression scale (SDS) were used to measure clinical symptoms. Compared with HCs, PPD patients showed increased fractional amplitude of low-frequency fluctuation (fALFF) in the Frontal_Mid_L and increased functional connectivity (FC) between the hypothalamus-R and the Cingulum_Mid_R. Correlation analysis suggested a positive correlation between PASI and SDS scores in PPD, while the fALFF and FC values were negatively correlated with their SDS and PASI scores. These brain regions may be associated with the development of depressive symptoms and disease severity in psoriasis patients.

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Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses

Cited by 25 publications

References 82 publications

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Vortioxetine Modulates the Regional Signal in First-Episode Drug-Free Major Depressive Disorder at Rest

Abnormal functional connectivity in psoriasis patients with depression is associated with their clinical symptoms

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