Hypercalcemia Secondary to Silicone Breast Implant Rupture: A Rare Entity to Keep in Mind

Rodriguez, Ivan E.; Deleyiannis, Frederic W.‐B.

doi:10.1097/gox.0000000000001416

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…In another similar case report, Agrawal et al reported hypercalcemia in a transgender patient receiving bilateral silicone breast implants [7]. Several other case reports also documented similar findings in female, transgender, and male patients [8][9][10][11]. Some of the patients, not all, responded well with correction of electrolyte imbalance (hydration) and steroids with or without administration of bisphosphonates [6,7,11].…”

Section: Discussionmentioning

confidence: 87%

“…Some of the patients, not all, responded well with correction of electrolyte imbalance (hydration) and steroids with or without administration of bisphosphonates [6,7,11]. Surgical removal of silicone granuloma was reported in two of the cases [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Hypercalcemia is the most common presentation of an underlying condition. Literature search reveals only a few such reported cases in female, transgender, and male patients following receiving silicone implants or injections or even topical preparations for cosmetic purposes [4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Modifying Beauty Is Not Priceless: A Rare Case of Silicone-Induced Hypercalcemia With Renal Failure

Fareen¹,

Zafar²,

Ahmed³

et al. 2022

Cureus

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Modifying Beauty Is Not Priceless: A Rare Case of Silicone-Induced Hypercalcemia With Renal Failure

Fareen¹,

Zafar²,

Ahmed³

et al. 2022

Cureus

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show abstract

“…Hydration and steroids, with or without bisphosphonates, were the mainstay of treatment, but with improvement in only five cases [3, 5, 6, 12, 13]. Surgical excision of silicone granulomas helped normalize serum calcium in two of the reported cases, [9] and removal of breast implants resulted in improvement in one case [10]. The current case is the second case involving hypercalcemia solely secondary to SBI rupture.…”

Section: Discussionmentioning

confidence: 98%

“…LSI were used in most cases with or without the implantation of SBI. In only one case, SBI was identified as the sole cause of hypercalcemia [10]. Also reported was the use of silicone with the help of transdermal ultrasound to remove wrinkles from the face and neck in one of the cases [5].…”

Section: Discussionmentioning

confidence: 99%

Silicone-Induced Granulomatous Reaction Causing Severe Hypercalcemia: Case Report and Literature Review

Dangol

Negrete

2019

Case Reports in Nephrology

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A 67-year-old woman presented to the hospital with complaints of abdominal pain. Physical exam was significant for signs of severe dehydration, mild epigastric tenderness and multiple non-tender hard nodules over her arms and thighs. Incidental finding of severe hypercalcemia led to negative workups for hyperparathyroidism, vitamin D intoxication, and malignancy. However, elevated levels of 1,25-hydroxy vitamin D raised the possibility of granulomatous diseases. Imaging and patient report revealed silicone-induced foreign body granulomatous reaction as the cause of hypercalcemia. Use of silicone for cosmetic enhancement of body contours can result in siliconomas, severe hypercalcemia, and complications. Treatment is unestablished for this condition. Increasing prevalence of cosmetic enhancement should prompt vigilance for this rare disease entity. Providers should counsel and educate individuals undergoing such procedures.

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Silicone Granulomatous Inflammation Resulting in Hypercalcemia: A Review of the Literature

Yedla

Perez

Lagari

et al. 2019

AACE Clinical Case Reports

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Objective: Silicone usage for cosmetic enhancement is common, although it is not approved by the U.S. Food and Drug Administration. Granulomatous inflammation leading to hypercalcemia is a rare complication. We present a case of non-parathyroid hormone (PTH), calcitriolmediated hypercalcemia in a woman with a history of cosmetic injections. Methods: Case report and review of the literature. Results: A 48-year-old female with metabolic syndrome was evaluated for severe hypercalcemia (calcium >15 mg/dL). Laboratory tests revealed low-normal PTH, normal 25-hydroxyvitamin D, elevated 1,25-dihydroxyvitamin D, and hypercalciuria. Imaging studies, including a computed tomography (CT) scan of the lungs, was nonrevealing. Positron emission tomography/CT showed symmetric hypermetabolic subcutaneous stranding of bilateral gluteus and proximal thighs. She admitted to silicone injections in the buttocks 10 years prior. Her examination was unremarkable except for an intermittent pruritic rash over the right thigh. Labs revealed total serum calcium 11.3 mg/dL, PTH 18 pg/mL, 24-hour urinary calcium 509 mg, and PTH-related peptide 18 pg/mL. Serum and urine electrophoresis were normal, 25-hydroxyvitamin

show abstract

Hypercalcemia Secondary to Silicone Breast Implant Rupture: A Rare Entity to Keep in Mind

Cited by 4 publications

References 5 publications

Modifying Beauty Is Not Priceless: A Rare Case of Silicone-Induced Hypercalcemia With Renal Failure

Modifying Beauty Is Not Priceless: A Rare Case of Silicone-Induced Hypercalcemia With Renal Failure

Silicone-Induced Granulomatous Reaction Causing Severe Hypercalcemia: Case Report and Literature Review

Silicone Granulomatous Inflammation Resulting in Hypercalcemia: A Review of the Literature

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