Hypercalcemia in osteolytic metastatic cancer of the breast

The Effect of Hypercalcemia Induced by Calciferol Upon Renal Concentrating Ability1

“…Polyuria and loss of renal concentrating ability have frequently been observed in patients with hypercalcemia (1)(2)(3)(4)(5)(6)(7)(8). It has not been clear whether the capacity of the kidneys to concentrate urine is selectively impaired by hypercalcemia or whether it is depressed together with many other renal functions as a result of substantial injury to and encroachment upon active renal parenchyma (9).…”

The Effect of Diethylstilbestrol on the Calcium, Phosphorus and Nitrogen Metabolism of Prostatic Carcinoma 1

“…The calcium balance is much less negative in this patient than is seen in a patient with a predominantly osteolytic type of metastasis, such as metastatic breast carcinoma (8). In agreement with this is the observation of a normal serum calcium; whereas in cases of extensive osteolytic metastasis, hypercalcemia is not infrequently seen (8,11,12 The effect of estrogens upon the calcium, phosphorus and nitrogen metabolism of metabolic bone disease has been carefully studied and described by Gardner and Pfeiffer (13), Reifenstein and Albright (14,15), and others. It has been noted that the effect of the estrogens on protein metabolism is less marked than the effect of androgens.…”

The effect of protamine derivatives on calcium metabolism in patients with malignancy.

“…Hypercalcaemia is a frequent complication in patients with malignant tumours (Woodard, 1953;Swyer, Berger, Gordon and Laszlo, 1950 15) responded to prolothan G therapy while the hypercalcaemia of case 14 wA,as unresponsive to the therapy. It would appear from the normal 47Ca blood-boIne dynamics of the patients studied (cases 6 and 15) that the prolothan G lhad Ino direct effect on the normal exchange and accretion processes in bone precluding any acute parathormone blocking action.…”