Hypercalcemia and Extensive Chest Metastasis of Vulvar Squamous Cell Carcinoma

Abstract

A 73-year-old woman with a diagnosis of vulvar carcinoma submitted to curative surgery 5 years previously, presented to the emergency department with prostration and vulvar haemorrhage. Although the gynaecological examination was unremarkable, she had a mass in the left chest wall and hypercalcemia. A CT scan of the thorax revealed a voluminous left hemithorax mass invading the mediastinum, lung, pleura and chest wall. Ultrasound-guided biopsy of the mass showed infiltration by a well-differentiated keratinizing squamous cell carcinoma (SCC). This case report describes an extremely rare metastatic pattern in vulvar SCC concomitant with paraneoplastic hypercalcemia.

An uncommon case of vulvar cancer metastatic to breast

“…Metastases to the mammary gland are also uncommon, representing 0.5% to 2% of malignant lesions of the breast, being the ones, most often exhibiting breast metastases include melanomas, lymphomas, ovarian cancer, lung tumors, neuroendocrine, and sarcomas [15][16][17][18]. Unlike primary carcinomas, breast metastases, in most cases, do not have spiculated margins, skin, or nipple retraction due to the absence of a desmoplastic reaction [19,20].…”