Hyperbranched cellulose polyester of oral thin film and nanofiber for rapid release of donepezil; preparation and in vivo evaluation

AnjiReddy, Keshireddy; Karpagam, S.

doi:10.1016/j.ijbiomac.2018.11.224

Cited by 20 publications

(5 citation statements)

References 22 publications

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“…Similar results were reported in a previous study that developed TIM-loaded PCL nanofibers with 415 times folding endurance ( 16 ). As it is obvious, the addition of both CA and EUD significantly decreased the folding endurance of PCL-CA and PCL-EUD compared to PCL-1 and PCL-2 formulations due to the much lower folding endurance of CA and EUD plain nanofibers which was also reported by previous studies compared to PCL nanofibers ( 31 32 ).…”

Section: Discussionsupporting

confidence: 71%

Development and evaluation of polycaprolactone-based electrospun nanofibers containing timolol maleate as a sustained-release device for treatment of glaucoma: in vivo evaluation in equine eye

et al. 2022

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Background and purpose: Prolonging the drug release can be a suitable approach to overcome the challenges related to topical ophthalmic administration of drugs especially the ones prescribed for chronic ailments. The sustained delivery of the drug would reduce the required frequency of administration which could extremely improve patient compliance and feeling of well-being. This study aimed to develop nanofibrous inserts for sustained ophthalmic delivery of timolol maleate (TIM) for the treatment of glaucoma. Experimental approach: Polycaprolactone-based nanofibers containing TIM were prepared using pure polycaprolactone or a blend of it with cellulose acetate or Eudragit RL100 polymers by the electrospinning method. Following the preparation, polymeric inserts were evaluated for morphological and physicochemical properties. The in vitro drug release was assessed and the in vivo efficacy of a selected insert in decreasing the intraocular pressure (IOP) was also evaluated in the equine eyes. Findings / Results: Prepared nanofibers indicated diameter ranged between 122-174 nm. The formulations showed suitable physicochemical properties and stability for ophthalmic administration. In vitro release study showed prolonged release of drug during more than 3 days. In vivo evaluation revealed that the prepared insert is non-irritant and non-toxic to the equine eyes while having suitable efficacy in decreasing the IOP during 6 days. Conclusions and implication: Prepared TIM inserts indicated a higher efficacy than commercial TIM eye drop in lowering IOP during a prolonged period. Thus, these formulations can be considered suitable for enhancing patient compliance by reducing the frequency of administration in the treatment of glaucoma.

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Section: Discussionsupporting

confidence: 71%

Development and evaluation of polycaprolactone-based electrospun nanofibers containing timolol maleate as a sustained-release device for treatment of glaucoma: in vivo evaluation in equine eye

et al. 2022

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“…The peaks at 4.32 and 3.65 ppm represented the proton peak of methylene in HBPs and proton peak of CH 2 OCH 2  in PEG flexible long chain, respectively. The proton peak of benzene ring in long‐chain polymer was located at 7.28 ppm 53 . The hydrogen peak intensity of methylene in the long chain was stronger than that in other positions, which was mainly due to the large amount of methylene in PEG.…”

Section: Resultsmentioning

confidence: 93%

“…The proton peak of benzene ring in long-chain polymer was located at 7.28 ppm. 53 The hydrogen peak intensity of methylene in the long chain was stronger than that in other positions, which was mainly due to the large amount of methylene in PEG. When the flexible long chain was grafted to HBPs, the strength of methylene peak increased, and the chemical shift of hydrogen on the flexible long chain was more prominent.…”

Section: Characterization Of Lchbpsmentioning

confidence: 94%

Preparation and characterization of compatibilized and toughened polylactic acid/cellulose acetate films by long‐chain hyperbranched polymers

Huang

Jin

Wang

et al. 2021

J of Applied Polymer Sci

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A type of long‐chain hyperbranched polymers (LCHBPs) was prepared by grafting hydroxyl‐terminated flexible long chain onto hyperbranched polymers (HBPs). The structure of LCHBPs was confirmed by Fourier transform infrared (FT‐IR) and nuclear magnetic resonance (1H‐NMR) analysis. It was then used as the modifier for toughening and compatibilizing the polylactic acid (PLA)/cellulose acetate (CA) blends. Upon the addition of LCHBPs, the compatibility between PLA and CA was improved, the dispersion of CA particles in PLA matrix was more uniform, and the brittle‐ductile tear transition of the PLA/CA blends was occurred. The crystallization of PLA was promoted by the addition of LCHBPs. By adding LCHBPs, glass transition temperature and cold crystallization temperature were reduced, the crystallizability was enhanced, and the crystallization temperature range was expanded. The thermal decomposition temperature of the PLA/CA was found increased with the addition of LCHBPs. When the content of LCHBPs was 1 phr, the elongation at break and the tear strength of the PLA/CA blends were increased by 484% and 38.24%, respectively. Meanwhile, the thermal stability and hydrophilic properties of the blend films were improved by adding LCHBPs.

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“…According to the report, the hyperbranched nanofiber formulations displayed remarkable mechanical durability and effective drug delivery properties. These findings indicate that the hyperbranched cellulose nanofiber holds significant promise as a feasible alternative to commercially accessible dosage forms [ 124 ]. Sequential electrospinning was employed to successfully fabricate a multilayer film, with the exterior layers comprising ethyl cellulose nanofibers, while the inner layer contained gelatin nanofibers loaded with curcumin [ 125 ].…”

Section: Manufacturing Methodsmentioning

confidence: 99%

Orodispersible Films: Current Innovations and Emerging Trends

Jacob,

Boddu,

Bhandare

et al. 2023

Pharmaceutics

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Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various aspects of ODFs and their potential as a drug delivery system. Recent advancements, including the detailed exploration of formulation components, such as polymers and plasticizers, are briefed. The review highlights the versatility of preparation methods, particularly the solvent-casting production process, and novel 3D printing techniques that bring inherent flexibility. Three-dimensional printing technology not only diversifies active compounds but also enables a multilayer approach, effectively segregating incompatible drugs. The integration of nanoparticles into ODF formulations marks a significant breakthrough, thus enhancing the efficiency of oral drug delivery and broadening the scope of the drugs amenable to this route. This review also sheds light on the diverse in vitro evaluation methods utilized to characterize ODFs, ongoing clinical trials, approved marketed products, and recent patents, providing a comprehensive outlook of the evolving landscape of orodispersible drug delivery. Current patient-centric approaches involve developing ODFs with patient-friendly attributes, such as improved taste masking, ease of administration, and enhanced patient compliance, along with the personalization of ODF formulations to meet individual patient needs. Investigating novel functional excipients with the potential to enhance the permeation of high-molecular-weight polar drugs, fragile proteins, and oligonucleotides is crucial for rapid progress in the advancing domain of orodispersible drug delivery.

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Hyperbranched cellulose polyester of oral thin film and nanofiber for rapid release of donepezil; preparation and in vivo evaluation

Cited by 20 publications

References 22 publications

Development and evaluation of polycaprolactone-based electrospun nanofibers containing timolol maleate as a sustained-release device for treatment of glaucoma: in vivo evaluation in equine eye

Development and evaluation of polycaprolactone-based electrospun nanofibers containing timolol maleate as a sustained-release device for treatment of glaucoma: in vivo evaluation in equine eye

Preparation and characterization of compatibilized and toughened polylactic acid/cellulose acetate films by long‐chain hyperbranched polymers

Orodispersible Films: Current Innovations and Emerging Trends

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