Hyperbaric oxygenation in transplantology

Abstract

The ability to eliminate any form of oxygen debt by transporting oxygen to organs and tissues, by dissolving it in body fluids, brings hyperbaric oxygenation to a new level of application in transplantology. The review discusses the pathophysiological aspects of hyperbaric oxygenation during ischemia and reinfusion, especially when used in transplantology, and also investigations on the use of hyperbaric oxygenation in model experiments and in clinical practice. Analysis of the efficacy of hyperbaric oxygenation therapy at various stages of the transplantation process (preconditioning, donation, organ storage, in the early and late post-transplant periods) allows us to conclude that this method should be more widely involved in transplantation practice.Authors declare no conflict of interest.

Prolonged hypothermic storage of oocytes of the European common frog Rana temporaria in a gas mixture of oxygen and carbon monoxide

“…In a large number of studies, it was shown that oxygen persufflation has the ability to increase storage time of donor organs [14][15][16]. Hyperoxia facilitates the diffusion of oxygen into the cell, activates oxidative phosphorylation, increases the synthesis of high-energy compound and reduces lactose levels in cells [17]. The combined use of CO and O 2 has proven to be highly effective in prolonging the storage time of warm-blooded animal organs by four to six times when compared to traditional hypothermal preservation techniques using specialized solutions [18][19][20][21].…”