Hyperbaric oxygen treatment induces antioxidant gene expression

Abstract

Although the underlying molecular causes of aging are not entirely clear, hormetic agents like exercise, heat, and calorie restriction may generate a mild pro-oxidant stress that induces cell protective responses to promote healthy aging. As an individual ages, many cellular and physiological processes decline, including wound healing and reparative angiogenesis. This is particularly critical in patients with chronic non-healing wounds who tend to be older. We are interested in the potential beneficial effects of hyperbaric oxygen as a mild hormetic stress on human microvascular endothelial cells. We analyzed global gene expression changes in human endothelial cells following a hyperbaric exposure comparable to a clinical treatment. Our analysis revealed an upregulation of antioxidant, cytoprotective, and immediate early genes. This increase coincided with an increased resistance to a lethal oxidative stress. Our data indicate that hyperbaric oxygen can induce protection against oxidative insults in endothelial cells and may provide an easily administered hormetic treatment to help promote healthy aging.

Effect of hyperbaric oxygen therapy on cerebral vasospasm: a vascular morphometric study in an experimental subarachnoid hemorrhage model

“…Intimal damage may play a role in the development of vasospasm by two different mechanisms: by reduction of nitric oxide, which is known to be a major relaxation factor released from endothelial cells, and by increasing exposure of spasmogens, such as ET-1, directly to underlying subendothelial smooth muscle cells [22]. This process might also be a target for HBOT since endothelial protection by HBOT has been documented in different experimental models [50,51].…”

Hyperbaric Medicine for the Hospital-Based Physician

“…1 The common theme underlying the rationale for HBO 2 effects that go well beyond local, transient tissue hyperoxygenation. 1 Third-party reimbursement for HBO 2 therapy generally follows these recommendations.…”

“…The Undersea and Hyperbaric Medical Society (UHMS) has approved 16 indications for HBO 2 (Table 1). 1 The common theme underlying the rationale for HBO 2 effects that go well beyond local, transient tissue hyperoxygenation.…”

Гипербарическая Оксигенация И Рак – Обзор (Перевод С Англ. Митрохина А.А.)

“…Более того, после лечения ГБО DMBA-индуцирован-ных опухолей молочной железы также in vivo было про-демонстрировано уменьшение пролиферации клеток одновременно со значительным изменением гистоло-гии (Raa, et Всё вместе это может свидетельствовать о том, что изменения концентрации кислорода влияют на антиок-сидантные пути (Godman, et al, 2010), что ведёт к изме-нению сигнализации о выживаемости клеток. Однако общая картина сложна и прежде, чем будут приняты ка-кие-либо окончательные заключения необходимо про-вести исследования этих механизмов.…”