Hyperbaric oxygen treatment in thromboangiitis obliterans: a retrospective clinical audit

Abstract

The addition of HBOT to conventional treatment in TAO patients with non-healing ischaemic wounds and severe extremity pain, conferred significant benefits in terms of wound healing and rest pain control. Multi-centre, prospective, randomized studies with blinded outcome analysis are now needed to elicit more reliable results.

Therapeutic Effects of Interventional Therapy and Conservative Therapy on Lower Extremity Arteriosclerosis Obliterans and Risk Factors for Prognosis

“…Atherosclerosis is the main cause for ASO. Hyperglycemia can lead to abnormal hormone secretion, vascular endothelial cell dysfunction and platelet dysfunction, thereby resulting in atherosclerosis [14]. Hypertension, especially high systolic blood pressure, has a stronger correlation with ASO, but its risk is lower than those of smoking and diabetes mellitus [15].…”

miR-100 alleviates the inflammatory damage and apoptosis of H2O2-induced human umbilical vein endothelial cells via inactivation of Notch signaling by targeting MMP9

“…1,2 It is a common refractory disease mainly involving the arteries and veins of the extremities, especially the lower extremities. [3][4][5] The diseased arterial lumen will become gradually stenosed and even occluded with the progression of the disease, which causes the distal limb ischemia, hypoxia, pain, and advanced stage of this disease often leads to distal gangrene, amputation. 6,7 The pathogenesis of TAO is mainly affected by internal and external factors: internal factors mainly include autoimmune dysfunction, estrogen, and genetic factors; external factors mainly include patients' smoking status, living in cold and humid environment, chronic injury, and infection.…”