Hyperbaric oxygen treatment decreases inflammation and mechanical hypersensitivity in an animal model of inflammatory pain

Hyperbaric Oxygen Treatment Is Comparable to Acetylsalicylic Acid Treatment in an Animal Model of Arthritis

“…Although inflammation and pain thresholds are correlated, distinct mechanisms are involved in each. 18 The purpose of this set of experiments was to explore the effect of hyperbaric oxygen therapy on joint inflammation and hyperalgesia in an animal model of arthritis, and compare these effects to aspirin treatment. As expected, based on previous findings, 18 both HBO and aspirin treatment decreased hyperalgesia and inflammation as compared with control animals in the animal model of arthritis.…”

“…5 Hyperbaric oxygen therapy has demonstrated efficacy in decreasing edema and hyperalgesia in inflammatory conditions. 5,15,18 The beneficial effects of hyperbaric oxygen therapy on inflammation make it an attractive treatment option for patients with chronic arthritis. Despite these indications for benefit, relatively few researchers have explored the effects of hyperbaric oxygen treatment on arthritis, and those that have provide mixed results.…”

Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders

“…HBOT has been shown to be effective at treating inflammation in various tissues, including the gut (Al-Waili & Butler 2006;Buchman et al 2001;Gorgulu et al 2006;Gulec et al 2004;Gurbuz et al 2003a, b;Nikfarjam et al 2007;Vlodavsky et al 2006;Wilson et al 2007;Wilson et al 2006). …”

Management of Fibromyalgia Syndrome

“…HBOT has been used to treat a range of conditions and is currently approved by the FDA to treat 13 conditions including decompression sickness, carbon monoxide toxicity and arterial insufficiency. In animal model, HBOT has been shown to have an antinociceptive effect via activation of endogenous opioids [137] and inhibition of the inflammatory response [138]. HBOT has also been tried to treat chronic pain conditions; the studies tend to be small and preliminary, but have yielded promising effects on pain management [82].…”