Hyperbaric Oxygen Treatment Is Comparable to Acetylsalicylic Acid Treatment in an Animal Model of Arthritis

Wilson, Hilary; Toepfer, Virginia E.; Senapati, Arun K.; Wilson, Judy R.; Fuchs, Perry N.

doi:10.1016/j.jpain.2007.06.005

Cited by 33 publications

(25 citation statements)

References 14 publications

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“…Based on evidence that HBO 2 reduced carrageenan-induced inflammation (Sümen et al, 2001; Wilson et al, 2006), it was posited that HBO 2 reduced inflammation-associated neuropathic pain through this anti-inflammatory action. Wilson et al (2007) also demonstrated that HBO 2 treatment was equieffective with aspirin in reducing both joint inflammation and hyperalgesia in rats following intraarticular injection of carrageenan.…”

Section: Discussionmentioning

confidence: 86%

“…Experimentally, HBO 2 treatment can reduce allodynia in rats with peripheral nerve injuries (Thompson et al, 2010; Li et al, 2011; Gu et al, 2012; Zhang et al, 2012) and experimental arthritis (Warren et al, 1979; Wilson et al, 2006, 2007). Research from our laboratory demonstrated that HBO 2 treatment effectively reduces pain in animal models of acute pain (Ohgami et al, 2009; Zelinski et al, 2009a; Chung et al, 2010; Quock et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Involvement of brain opioid receptors in the anti-allodynic effect of hyperbaric oxygen in rats with sciatic nerve crush-induced neuropathic pain

et al. 2013

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Earlier research has demonstrated that hyperbaric oxygen (HBO2) can produce an antinociceptive effect in models of acute pain. Recent studies have revealed that HBO2 can produce pain relief in animal models of chronic pain as well. The purpose of the present investigation was to ascertain whether HBO2 treatment might suppress allodynia in rats with neuropathic pain and whether this effect might be blocked by the opioid antagonist naltrexone (NTX). Male Sprague Dawley rats were subjected to a sciatic nerve crush under anesthesia and mechanical thresholds were assessed using an electronic von Frey anesthesiometer. The time course of the HBO2-induced anti-allodynic effect in different treatment groups was plotted, and the area-under-the-curve (AUC) was determined for each group. Seven days after the nerve crush procedure, rats were treated with HBO2 at 3.5 atmospheres absolute (ATA) for 60 min and exhibited an anti-allodynic effect, compared to nerve crush-only control rats. Twenty-four hours before HBO2 treatment, another group of rats was implanted with Alzet® osmotic minipumps that continuously released NTX into the lateral cerebral ventricle for 7 days. These NTX-infused, HBO2-treated rats exhibited an allodynic response comparable to that exhibited by rats receiving nerve crush only. Analysis of the AUC data showed that HBO2 significantly reduced the nerve crush-induced allodynia; this anti-allodynic effect of HBO2 was reversed by NTX. These results implicate opioid receptors in the pain relief induced by HBO2.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Involvement of brain opioid receptors in the anti-allodynic effect of hyperbaric oxygen in rats with sciatic nerve crush-induced neuropathic pain

et al. 2013

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“…22,[25][26][27] Third, HBOT may use an osmotic effect of hyperoxia to reduce edema in the operative site and, therefore, promote oxygen diffusion. 24,28 Finally, HBOT is known to have an antiinflammatory effect, 29 and this may partly explain the low recurrence rate observed in this study. A key determinant of pterygium recurrence is prolonged postoperative inflammation, and a notable clinical feature of the patients treated in this study was that the grafts were relatively uninflamed from early in the postoperative course (Fig.…”

Section: Discussionmentioning

confidence: 69%

Use of Adjuvant Hyperbaric Oxygen Therapy to Support Limbal Conjunctival Graft in the Management of Recurrent Pterygium

Assaad

Chong

Tat

et al. 2011

Cornea

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“…HBOT has been shown to be effective at treating inflammation in various tissues, including the gut (Al-Waili & Butler 2006;Buchman et al 2001;Gorgulu et al 2006;Gulec et al 2004;Gurbuz et al 2003a, b;Nikfarjam et al 2007;Vlodavsky et al 2006;Wilson et al 2007;Wilson et al 2006). …”

Section: Proposed Mechanism Of Actionmentioning

confidence: 99%

Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders

Jepson

Granpeesheh

Tarbox

et al. 2010

J Autism Dev Disord

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Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total of 16 participants with autism spectrum disorders. No consistent effects were observed across any group or within any individual participant, demonstrating that HBOT was not an effective treatment for the participants in this study. This study represents the first relatively large-scale controlled study evaluating the effects of HBOT at the level of the individual participant, on a wide array of behaviors.

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Hyperbaric Oxygen Treatment Is Comparable to Acetylsalicylic Acid Treatment in an Animal Model of Arthritis

Cited by 33 publications

References 14 publications

Involvement of brain opioid receptors in the anti-allodynic effect of hyperbaric oxygen in rats with sciatic nerve crush-induced neuropathic pain

Involvement of brain opioid receptors in the anti-allodynic effect of hyperbaric oxygen in rats with sciatic nerve crush-induced neuropathic pain

Use of Adjuvant Hyperbaric Oxygen Therapy to Support Limbal Conjunctival Graft in the Management of Recurrent Pterygium

Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders

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