Hyperbaric oxygen treatment attenuates cytokine induction after massive hemorrhage

Yamashita, Misuzu; Yamashita, Mamoru

doi:10.1152/ajpendo.2000.278.5.e811

Cited by 41 publications

(33 citation statements)

References 26 publications

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“…This is supported by animal studies in which it was shown that HBO inhibits interleukin (IL)-1 production (Inamoto et al 1991;Saito et al 1991). One recent study has shown that HBO attenuates the production of TNF-a, IL-6, and their respective hepatic mRNAs after massive hemorrhage (Yamashita and Yamashita 2000). Our data provide further evidence that HBO inhibits TNF-a production in intestinal ischemia-reperfusion injury.…”

Section: Discussionsupporting

confidence: 79%

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Hyperbaric O 2 reduces intestinal ischemia-reperfusion-induced TNF-α production and lung neutrophil sequestration

Yang

Bosco

Montante

et al. 2001

European Journal of Applied Physiology

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Treatment with hyperbaric O2 (HBO) ameliorates ischemia-reperfusion (I/R) injury. Since tumor necrosis factor-alpha (TNF-alpha) plays an important role in I/R injury, we hypothesized that the effect of HBO in I/R injury may be due to its ability to inhibit TNF-alpha production. In this study, one group of rats received HBO during 60 min of ischemia (HBO group, n = 9), while control rats endured the same procedure but did not receive HBO (non-HBO, n = 9). A group of sham-operated control rats (SHAM, n = 6) underwent laparotomy without occlusion of the artery and HBO treatment. Intestinal I/R led to an increase in serum TNF-alpha concentration to [mean (SEM)] 165 (32) pg/ml (P < 0.01 vs SHAM rats). HBO attenuated this increase [34 (9) pg/ml; P<0.05 vs non-HBO group]. Intestinal I/R also resulted in a marked increase in lung myeloperoxidase content [0.62 (0.04) U/g vs 0.17 (0.02) U/g of SHAM rats, P<0.01]. HBO suppressed this increase [0.40 (0.04) U/g, P<0.05 vs non-HBO rats]. HBO ameliorated the injury to the intestine and lung. The number of neutrophils sequestered in the lung was reduced in HBO rats compared to non-HBO rats [6.4 (0.9) neutrophils/per oil field and 10.9 (2) neutrophils/per oil field, respectively; P < 0.05]. These findings demonstrate that HBO inhibits TNF-alpha production during intestinal I/R, and this reduced TNF-alpha production may be attributed to the beneficial effects of HBO.

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Section: Discussionsupporting

confidence: 79%

“…Clearly, the damaged intestine is most responsible for the induction of TNF-a. HBO decreases TNF production during massive hemorrhage, and this is thought to be attributable to improved oxygenation (Yamashita and Yamashita 2000). In our study, HBO attenuated local ischemic damage, thus contributing to a reduction in TNF-a production.…”

Section: Discussionsupporting

confidence: 58%

Hyperbaric O 2 reduces intestinal ischemia-reperfusion-induced TNF-α production and lung neutrophil sequestration

Yang

Bosco

Montante

et al. 2001

European Journal of Applied Physiology

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“…This effect seems to be consistent with hypobaric oxygen therapy (HBOT) studies carried out in ex vivo cell cultures [3,30,54]. These findings are also in agreement with studies demonstrating that HBOT attenuates pro-inflammatory cytokine production of systemic inflammation in animal models [32,57,58].…”

Section: Introductionsupporting

confidence: 87%

“…All these findings are also in agreement with studies demonstrating that HBOT attenuates proinflammatory cytokine production in animal models of systemic inflammation. Thus, Yamashita and Yamashita [57] observed that HBOT reduced inflammatory cytokine induction by improving liver ischemia. In another study, TNF- levels were reduced in rats after the treatment of an inflammatory state with HBOT [32].…”

Section: Discussionmentioning

confidence: 97%

Effects of hyperoxia exposure on metabolic markers and gene expression in 3T3-L1 adipocytes

et al. 2012

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Adipose tissue often becomes poorly oxygenated in obese subjects. This feature may provide cellular mechanisms involving chronic inflammation processes such as the release of proinflammatory cytokines and macrophage infiltration. In this context, the purpose of the present study was to determine whether a hyperoxia exposure on mature adipocytes may influence the expression of some adipokines and involve favorable changes in specific metabolic variables. 3T3-L1 adipocytes (14 days differentiated) were treated with 95% oxygen for 24 h. Cell viability, intra and extracellular reactive oxygen especies (ROS) content, glucose uptake and lactate and glycerol concentrations were measured in the culture media. Also, mRNA levels of HIF-1, leptin, IL-6, MCP-1, PPAR-, adiponectin, and ANGPTL-4 were analyzed.Hyperoxia treatment increased intra and extracellular ROS content, reduced glucose uptake and lactate release and increased glucose release. It also led to an upregulation of the expression of IL-6, MCP-1 and PPAR-, while ANGPTL4 was downregulated in the hyperoxia group with respect to control. The present data shows that hyperoxia treatment seems to provoke an inflammatory response due to the release of ROS and the upregulation of pro-inflammatory adipokines, such as IL-6 and MCP-1. On the other hand, hyperoxia may have an indirect effect on the improvement of insulin sensitivity, due to the upregulation of PPAR- gene expression as well as a possible modulation of both glucose and lipid metabolic markers. To our knownledge, this is the first study analyzing the effect of hyperoxia in 3T3-L1 adipocytes.

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“…Hyperbaric-oxygen (HBO) therapy may simultaneously provide beneficial effect directed at many components responsible for ischemia-reperfusion injury, including the neutrophil, endothelium, inflammatory mediators, lipid peroxidation, cellular energetics and microvascular blood flow [7][8][9][10][11]. It has been reported that HBO treatment may modulate kidney function in rats with sepsis, rats with adriamycin-induced nephrotic syndrome and experimental cyclosporine nephrotoxicity [12].…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric-oxygen treatment: An adjunctive therapy in acute renal failure due to crush injury

Kazancıoğlu¹,

Gulgun²,

Aydın³

et al. 2012

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Objective: Major seismic events leave their survivors trapped under the rubble leading to extensive muscle damage and its devastating sequale of hemodynamic and metabolic disturbances and acute renal failure. Hypoxemia aggravated during each hemodialysis (HD) session is important in acute renal failure patients with massive tissue injury. We retrospectively analyzed the adjunctive role of hyperbaric-oxygen (HBO) therapy in patients treated with HD for acute renal failure due to crush injury in terms of dialysis duration. Patients and Methods: 16 patients admitted after the 1999 Marmara earthquake to Istanbul Faculty of Medicine were treated with HBO. Only 8 (2 M, 6 F, mean age: 24.8 + 7.3 years) of them had required HD treatment. 29 (16 M, 13 F, mean age: 34.6 + 12.9 years) crush syndrome patients treated with HD but not with HBO were taken as controls and the clinical and laboratory data of the two groups were compared. Results: The mean duration time under the rubble for the HBO group was 9.4 + 3.2 hours. Mainly lower extremity fasciotomies were performed at 15.6 + 14.8 hours after extrication. There were no amputations in this group. There were three amputations in the control group. The mean number of HD sessions was 9.2 + 6.7/patient for 10.9 + 9.6 days until renal functions recovered and the patients had 27.4 + 15.6 HBO sessions until the recovery of their lesions. There were no correlations between the number of HBO sessions and any laboratory parameter nor the number of HD sessions. There was no statistical difference in the need for HD between the HBO and control group. Conclusions: Our results could not demonstrate a significant effect of HBO treatment in terms of HD duration; however, the valuable contribution of the HBO treatment was to increase the salvage of crushed limbs.

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Hyperbaric oxygen treatment attenuates cytokine induction after massive hemorrhage

Cited by 41 publications

References 26 publications

Hyperbaric O 2 reduces intestinal ischemia-reperfusion-induced TNF-α production and lung neutrophil sequestration

Hyperbaric O 2 reduces intestinal ischemia-reperfusion-induced TNF-α production and lung neutrophil sequestration

Effects of hyperoxia exposure on metabolic markers and gene expression in 3T3-L1 adipocytes

Hyperbaric-oxygen treatment: An adjunctive therapy in acute renal failure due to crush injury

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