Hyperbaric oxygen therapy reduces the risk of QTc interval prolongation in patients with diabetes and hard-to-heal foot ulcers

Fagher, Katarina; Katzman, Per; Löndahl, Magnus

doi:10.1016/j.jdiacomp.2015.07.023

Cited by 10 publications

(10 citation statements)

References 36 publications

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“…After a 2-year follow-up, QTc time was significantly shorter in the HBOT group, whose members had received 40 treatment sessions at 2.5 ATA, compared with the placebo group [28].…”

Section: Hyperbaric Oxygen Therapymentioning

confidence: 88%

Selected physical medicine interventions in the treatment of diabetic foot syndrome

et al. 2016

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The diabetic foot syndrome (DFS) is among chronic complications of diabetes mellitus; it can affect individuals with both type 1 and type 2 diabetes. Diabetic patients have up to a 25% lifetime risk of developing DFS, which is both a medical and social problem. Several studies have indicated that, apart from pharmacotherapy and modern active wound dressings, physical medicine also has a role in prevention and management of diabetic foot ulcers. The paper presents physical medicine interventions most recognized in the conservative management of DFS.

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“…After a 2-year follow-up, QTc time was significantly shorter in the HBOT group, whose members had received 40 treatment sessions at 2.5 ATA, compared with the placebo group [28].…”

Section: Hyperbaric Oxygen Therapymentioning

confidence: 88%

Selected physical medicine interventions in the treatment of diabetic foot syndrome

et al. 2016

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“…The QTc interval is the measured QT interval corrected for heart rate using Bazett's formula (QT/RRK). QTc prolongation has been defined as follows: longer than 440 ms in men and longer than 460 ms in women [ 2 , 20 ].…”

Section: Methodsmentioning

confidence: 99%

Predictive Role of QTc Prolongation in Carbon Monoxide Poisoning-Related Delayed Neuropsychiatric Sequelae

Liao

Mao

Hung

et al. 2018

BioMed Research International

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Objective Delayed neuropsychiatric sequelae (DNS) are serious complications of carbon monoxide (CO) poisoning that adversely affect poisoned patients' quality of life as well as socioeconomic status. This study aimed to determine clinical predictors of DNS in patients with CO poisoning. Methods This retrospective study included all CO-poisoned patients admitted to the emergency department (ED) of Linkou Chang Gung Memorial Hospital in Taiwan from 1 January 2009 to 31 December 2015. The medical records of all patients with CO poisoning were carefully reviewed, and relevant data were abstracted into a standardised form. Univariate and multivariate logistic regression models were used to identify predictors of DNS after CO poisoning. Receiver operating characteristic (ROC) curve analysis was used to determine the ideal cut-off value for continuous variables that predict the development of DNS. Results A total of 760 patients with CO poisoning were identified during the study period. Among them, 466 were eligible for the analysis of predictors of DNS. In multivariate analysis, Glasgow Coma Scale <9 (odds ratio [OR], 2.74; 95% confidence interval [CI], 1.21–6.21), transient loss of consciousness (OR, 3.59; 95% CI, 1.31–9.79), longer duration from CO exposure to ED presentation (OR, 1.05; 95% CI, 1.03–1.08), and corrected QT (QTc) prolongation (OR, 2.61; 95% CI, 1.21–5.61) were found to be associated with a higher risk of DNS. The area under the ROC curve (AUC) for QTc interval measured within 6 h after exposure best predicted the development of DNS, with a result of 0.729 (95% CI 0.660–0.791). Moreover, the best cut-off value of the QTc interval was 471 ms, with a sensitivity of 53.3% and a specificity of 85.1%. Conclusions We identified several potential predictors of DNS following CO poisoning. Among them, QTc prolongation found within 6 h after exposure is a novel predictor of DNS, which may be helpful in the future care of patients with CO poisoning.

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“…Few studies have addressed the association of QTc with DFUs. Katarina Fagher et al found in DFUs patients, QTc prolongation was associated with increased mortality [17,27] and hyperbaric oxygen therapy might protect against QTc prolongation [28] . Shumin Wang found QTc prolongation was associated with a higher CVDs mortality in DFU patients, but it cannot predict ulcer healing or recurrence.…”

Section: Discussionmentioning

confidence: 99%

Association Between Heart Rate-corrected QT Interval and Severe Peripheral Arterial Disease in Patients with Type 2 Diabetes and Foot Ulcers:Aa Case Control Study

Hong

Liu

et al. 2020

Preprint

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Background: Half of patients with diabetes and foot ulcers (DFUs) have co-existing peripheral arterial disease (PAD). Prolonged heart rate-corrected QT (QTc) interval was found to be associated with PAD in a general population. The goal of the present study was to investigate the relationship between QTc interval and PAD in patients with DFUs.Methods: The present multi-center cross-sectional study enrolled 281 patients with DFUs. Severity of PAD was classified as no-severe PAD group (no obvious abnormality or plaques) and severe PAD group (stenosis or occlusion) according to duplex ultrasonography. QTc was calculated according to the Bazett formula. The study population was divided into subgroups based on the QTc tertiles. Results: The patients with severe PAD had longer QTc interval (P = 0.004) and higher prevalence of prolonged QTc (P = 0.042) than those with no-severe PAD. After adjustment for gender and age, partial correlation analysis revealed positive relationship of QTc with prevalence of severe DFUs (r = 0.194, P = 0.001) and severe PAD (r = 0.118, P = 0.048). Univariate logistic analysis showed that the QTc was positively associated with severe PAD (odds ratio [OR] = 1.010, P = 0.014). Compared to those in lowest tertile of QTc, the ORs for severe PAD were increased significantly and independently for those in upper tertiles of QTc (both P < 0.05). Conclusions: Prolonged QTc interval was independently associated with severe PAD in patients with DFUs, which might indicate the worse progression of peripheral atherosclerosis in early stage for this population.

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Hyperbaric oxygen therapy reduces the risk of QTc interval prolongation in patients with diabetes and hard-to-heal foot ulcers

Cited by 10 publications

References 36 publications

Selected physical medicine interventions in the treatment of diabetic foot syndrome

Selected physical medicine interventions in the treatment of diabetic foot syndrome

Predictive Role of QTc Prolongation in Carbon Monoxide Poisoning-Related Delayed Neuropsychiatric Sequelae

Association Between Heart Rate-corrected QT Interval and Severe Peripheral Arterial Disease in Patients with Type 2 Diabetes and Foot Ulcers:Aa Case Control Study

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