Hyperbaric oxygen therapy reduces renal lactate production

Nørlinger, Thomas Stokholm; Nielsen, Per Mose; Qi, Haiyun; Mikkelsen, E.; Hansen, Karl B.; Schmidt, N; Pedersen, Michael; Agger, Peter; Palm, Fredrik; Laustsen, Christoffer

doi:10.14814/phy2.13217

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…Like the perfusion groups, PE and PE-O 2 had higher levels of lactic acid in the preservation solution because the organs were flushed, but PE-Hyp did not show this increased level. During perfusion, the hyperbaric oxygenation probably stimulated a better aerobic metabolism, yielding higher ATP and lower lactate concentrations, as previously reported by other authors in different experimental settings [ 33 – 35 ]. The reduced lactate production may contribute to the beneficial effect of the hyperbaric oxygenation in ischemia/reperfusion injury.…”

Section: Discussionsupporting

confidence: 77%

Strategies to Restore Adenosine Triphosphate (ATP) Level After More than 20 Hours of Cold Ischemia Time in Human Marginal Kidney Grafts

et al. 2018

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BackgroundThe persisting organ shortage in the field of transplantation recommends the use of marginal kidneys which poorly tolerate ischemic damage. Adenosine triphosphate (ATP) depletion during cold ischemia time (CIT) is considered crucial for graft function. We tested different strategies of kidney perfusion before transplantation in the attempt to improve the technique.Material/MethodsTwenty human discarded kidneys from donors after brain death and with at least 20 hours of CIT were randomized to the following experimental groups (treatment time three-hours at 4°C): a) static cold storage (CS); b) static cold hyperbaric oxygenation (Hyp); c) hypothermic perfusion (PE); d) hypothermic perfusion in hyperbaric oxygenation (PE-Hyp); and e) hypothermic oxygenated perfusion (PE-O2).ResultsHistological results showed that perfusion with or without oxygen did not produce any endothelial damage. A depletion of ATP content following the preservation procedure was observed in CS, PE, and Hyp, while PE-Hyp and PE-O2 were associated with a net increase of ATP content with respect to baseline level. In addition, PE-Hyp was associated with a significant downregulation of endothelial isoform of nitric oxide synthase (eNOS) gene expression and of hypoxia inducible factor-1α (HIF-1α).ConclusionsHyperbaric or normobaric oxygenation with perfusion improves organ metabolic preservation compared to other methods. This approach may prevent the onset of delayed graft function, but clinical trials are needed to confirm this.

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Section: Discussionsupporting

confidence: 77%

Strategies to Restore Adenosine Triphosphate (ATP) Level After More than 20 Hours of Cold Ischemia Time in Human Marginal Kidney Grafts

et al. 2018

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“…Relevant mechanisms by which HBOT improves glucose metabolism, as shown in animal models, include enhancements in oxidative capacity and GLUT4 expression in skeletal muscle [ 168 , 169 ], as well as increases in brown adipose tissue volume and thermogenesis by upregulating protein levels of UCP1 and PGC−1α [ 168 , 170 ]. Moreover, HBOT has been proven to be beneficial for treating diabetic kidney disease (DKD) in animal studies [ 171 , 172 ] and preliminary clinical trials [ 173 , 174 ]. Considering the well-established role of HBOT in diabetic foot ulcers, along with the potential benefits of HBOT on blood glucose and DKD, there is a strong case for further research on role of HBOT in treatment and prevention of the development of diabetes mellitus.…”

Section: Therapeutic Implications Of Hbot In Aging Interventionmentioning

confidence: 99%

Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics

Duan

Sun

et al. 2022

Redox Biology

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“…The applied procedures and HBOT-protocol was similar to a previous STZ induced diabetic animal study [28]. In short, HBOT consisted of 10 sessions of pressurization with 100% oxygen to 309 kPa (3 atm) with 5 pressurization sessions per week.…”

Section: Methodsmentioning

confidence: 99%

Hyperbaric Oxygen Treatment for Diabetic Retinopathy and Neuropathy in a Streptozotocin Induced Diabetic Rat Model

Madsen¹,

Skov²,

Hansen³

et al. 2021

JBiSE

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Aim: Diabetes Mellitus is a global public health challenge with major and potentially devastating complications, and concomitant complications include retinopathy and neuropathy due to hypoxia and microvascular dysfunction. In this study, we investigated the effect of hyperbaric oxygen therapy as a method to transiently improve tissue oxygenation on diabetic retinopathy and neuropathy in a streptozotocin induced type-1 diabetic rat model (Wistar). Methods: Streptozotocin induced type-1 diabetic rats received 10 sessions of 2-h hyperbaric oxygen exposures (pO 2 = 309 kPa) over 2 weeks. Animals were exposed to light stimuli to produce light evoked potentials to estimate the effect of oxygen treatment on diabetic retinopathy. Sciatic nerves were exposed and stimulated to produce muscle evoked potential, which were recorded in the muscles of the foot and subsequently used to evaluate the effect of oxygen treatment on diabetic neuropathy. Results: We found significantly shorter light evoked potential latency and increased amplitude in hyperbaric oxygen treated animals. No change was found in nerve conduction. Conclusions: This study showed that hyperbaric oxygen therapy is a potentially effective treatment for diabetic retinopathy, improving both latency and amplitude of light evoked potentials.

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Hyperbaric oxygen therapy reduces renal lactate production

Cited by 13 publications

References 31 publications

Strategies to Restore Adenosine Triphosphate (ATP) Level After More than 20 Hours of Cold Ischemia Time in Human Marginal Kidney Grafts

Strategies to Restore Adenosine Triphosphate (ATP) Level After More than 20 Hours of Cold Ischemia Time in Human Marginal Kidney Grafts

Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics

Hyperbaric Oxygen Treatment for Diabetic Retinopathy and Neuropathy in a Streptozotocin Induced Diabetic Rat Model

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