Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics

Fu, Qiaoyu; Duan, Ran; Sun, Yu; Li, Qingfeng

doi:10.1016/j.redox.2022.102352

Cited by 17 publications

(19 citation statements)

References 199 publications

(290 reference statements)

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“…of oxygen levels can enhance the antioxidant defenses [1,49]. We therefore investigated extremes, from 0.1 ATA (Summit of Kilimanjaro (5791 m)) to 2.5 ATA (therapeutic hyperbaric oxygen sessions), and several intermediate oxygen levels relevant to highaltitude exposure (2400 to 2700 m) or O2 levels used during closed circuit rebreather (CCR) diving-either in recreational, technical, or military diving (0.15, 0.30, 1.0, and 1.4 ATA) [12,50,51].…”

Section: Microparticles Elicited After One Hour Of Different Oxygen E...mentioning

confidence: 99%

“…However, when it comes to analyzing the biological responses to oxygen level variation, the trade-off between hypoxia and hyperoxia is not obvious. Large deviations from normoxia generally lead to increased oxidative stress, while the slight modulation of oxygen levels can enhance the antioxidant defenses [ 1 , 49 ]. We therefore investigated extremes, from 0.1 ATA (Summit of Kilimanjaro (5791 m)) to 2.5 ATA (therapeutic hyperbaric oxygen sessions), and several intermediate oxygen levels relevant to high-altitude exposure (2400 to 2700 m) or O 2 levels used during closed circuit rebreather (CCR) diving—either in recreational, technical, or military diving (0.15, 0.30, 1.0, and 1.4 ATA) [ 12 , 50 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

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Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward a Targeted Use of Oxygen?

Balestra

Arya

Leveque

et al. 2022

IJMS

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Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over a large range of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 ± 13.4 years, height: 172.7 ± 10.07 cm; weight 68.4 ± 15.7 kg) were randomly assigned, and blood samples were taken before and 2 h after each exposure. Microparticles (MPs) expressing proteins specific to different cells were analyzed, including platelets (CD41), neutrophils (CD66b), endothelial cells (CD146), and microglia (TMEM). Phalloidin binding and thrombospondin-1 (TSP), which are related to neutrophil and platelet activation, respectively, were also analyzed. The responses were found to be different and sometimes opposite. Significant elevations were identified for MPs expressing CD41, CD66b, TMEM, and phalloidin binding in all conditions but for 1.4 ATA, which elicited significant decreases. Few changes were found for CD146 and TSP. Regarding OPB, further investigation is needed to fully understand the future applications of such findings.

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Section: Microparticles Elicited After One Hour Of Different Oxygen E...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward a Targeted Use of Oxygen?

Balestra

Arya

Leveque

et al. 2022

IJMS

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“…First, there were anti-in ammatory and anti-apoptotic effects due to HBO treatment. Several studies have suggested that HBOT has an anti-in ammatory effect on various diseases, including idiopathic sensorineural hearing loss, delayed encephalopathy after carbon monoxide poisoning, necrotising soft tissue infections, gas gangrene, and traumatic brain damage [18][19][20]. Moreover, patients may experience post-CPR syndrome due to ischaemia-reperfusion injury to systemic tissues, which is particularly pronounced in the brain [21].…”

Section: Discussionmentioning

confidence: 99%

Clinical effects of hyperbaric oxygen therapy on paroxysmal sympathetic hyperactivity after cardiopulmonary resuscitation: a case series

Wang

Zhao³

et al. 2023

Preprint

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Background After cardiopulmonary resuscitation (CPR), paroxysmal sympathetic hyperactivity (PSH) will appear due to extensive brain injury. PSH is a serious clinical syndrome, and it is often treated with drugs. However, the application of hyperbaric oxygen in the treatment(HBOT) of PSH is rarely reported in the literature.We aimed to investigate the clinical effects of single-chamber pure oxygen treatment on PSH following CPR. Methods We retrospectively analysed clinical data of four patients treated at our hospital who developed signs of PSH post-CPR and received HBOT at an early stage to assess the clinical effects of HBOT on PSH. Results Following 3–4 HBOT sessions, signs of PSH were substantially diminished, and patients’ Clinical Symptom Scale scores decreased significantly. The time to awakening was 34, 25, 38, and 28 days for cases 1–4, respectively. Conclusions HBOT alleviated PSH, reduced brain damage, and promoted a return to full consciousness. HBOT efficacy was significant in these patients, and promoting HBOT in the clinical setting is recommended.

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“…29,65 This phenomenon is characterized by a transition from the hyperoxygenic condition to the normoxygenic condition, resulting in relative hypoxia without reaching a harmful hypoxic level. 28,29 In the long-term hypoxia, the two major members of hypoxia-inducible factors (HIFs) family including HIF-1α and HIF-2α are transcription factors that were shown to serve as the master indicator of hypoxia and play crucial role in the cellular response to low-oxygen levels. 66 Both HIF-1α and HIF-2α are involved in managing prolonged oxidative damage in aging-and obesity-related diseases.…”

Section: Osteoblast Differentiation and Function Markers In Bonementioning

confidence: 99%

Hyperbaric oxygen therapy exerts anti‐osteoporotic effects in obese and lean D‐galactose‐induced aged rats

Imerb,

Thonusin,

Pratchayasakul

et al. 2023

The FASEB Journal

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Obesity accelerates the aging processes, resulting in an aggravation of aging‐induced osteoporosis. We investigated the anti‐osteoporotic effect of hyperbaric oxygen therapy (HBOT) in obese‐ and lean‐aged rats through measurement of cellular senescence, hypoxia, inflammation, antioxidants, and bone microarchitecture. Obese and lean male Wistar rats were injected with 150 mg/kg/day of D‐galactose for 8 weeks to induce aging. Then, all rats were randomly given either sham or HBOT for 14 days. Metabolic parameters were determined. Expression by bone mRNA for cellular senescence, hypoxia, inflammation, antioxidative capacity, and bone remodeling were examined. Micro‐computed tomography and atomic absorption spectroscopy were performed to evaluate bone microarchitecture and bone mineral profiles, respectively. We found that HBOT restored the alterations in the mRNA expression level of p16, p21, HIF‐1α, TNF‐α, IL‐6, RANKL, RANK, NFATc1, DC–STAMP, Osx, ALP, and Col1a1 in the bone in obese‐and lean‐ aging rats. In obese‐aging rats, HBOT increased the level of expression of Sirt1 and CuZnSOD mRNA and diminished the expression level of HIF‐2α and ctsk mRNA to the same levels as the control group. However, HBOT failed to alter catalase and OCN mRNA expression in obese‐aged rats. HBOT partially improved the bone microarchitecture in obese‐aged rats, but completely restored it in lean‐aged rats. Interestingly, HBOT protected against obesity‐induced demineralization in obese‐aged rats. In summary, HBOT exerts an anti‐osteoporotic effect in lean‐aged rats and prevents some, but not all the negative effects of obese‐aged conditions on bone health. Therefore, HBOT is considered as a potential therapy for aging‐induced osteoporosis, regardless of obese status.

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Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics

Cited by 17 publications

References 199 publications

Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward a Targeted Use of Oxygen?

Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward a Targeted Use of Oxygen?

Clinical effects of hyperbaric oxygen therapy on paroxysmal sympathetic hyperactivity after cardiopulmonary resuscitation: a case series

Hyperbaric oxygen therapy exerts anti‐osteoporotic effects in obese and lean D‐galactose‐induced aged rats

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