Hyperbaric oxygen therapy mobilized circulating stem cells and improved delayed encephalopathy after acute carbon monoxide poisoning with up-regulation of brain-derived neurotrophic factor

Zhang, Lina; Sun, Qing; Xin, Qun; Qin, Jiangnan; Zhang, Lu; Wu, Di; Gao, Guangkai; Yujun, Xia

doi:10.1016/j.ajem.2021.01.021

Cited by 11 publications

(6 citation statements)

References 34 publications

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“…As described in Section 3.1 , HBOT mobilizes SPCs by stimulating NOS, increasing its circulating population and intracellular regulatory protein content [ 52 , 110 ]. The mobilized SPCs have been found to be engaged in wound healing [ 110 , 111 ] and cognition enhancement [ 112 , 113 ]. Second, HBOT can cause changes intrinsic to SPCs, including the promotion of stem cell proliferation and differentiation, as well as the regulation of protein secretion.…”

Section: The Mechanisms By Which Hbot Intervenes Agingmentioning

confidence: 99%

Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics

Duan

Sun

et al. 2022

Redox Biology

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Section: The Mechanisms By Which Hbot Intervenes Agingmentioning

confidence: 99%

Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics

Duan

Sun

et al. 2022

Redox Biology

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“…HBOT was also shown to enhance mobilization of bone marrow stem cells to an ischemic area and the release of trophic factors that can promote brain and neuronal recovery and enhance neurogenesis [25]. Interestingly, in patients with delayed encephalopathy after acute carbon monoxide poisoning, HBOT mobilized, circulating stem cells in the peripheral blood, which was associated with improved cognition [71]. In a TBI rat model, HBOT stimulated angiogenesis as evidenced by a higher number of BrdU-and VEGF-positive cells, and an increase in the number of BrdU-and NeuNpositive cells, suggesting enhanced neurogenesis [72].…”

Section: Neurogenesis and Angiogenesismentioning

confidence: 99%

Hyperbaric Oxygen Treatment—From Mechanisms to Cognitive Improvement

2021

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Hyperbaric oxygen treatment (HBOT)—the medical use of oxygen at environmental pressure greater than one atmosphere absolute—is a very effective therapy for several approved clinical situations, such as carbon monoxide intoxication, incurable diabetes or radiation-injury wounds, and smoke inhalation. In recent years, it has also been used to improve cognition, neuro-wellness, and quality of life following brain trauma and stroke. This opens new avenues for the elderly, including the treatment of neurological and neurodegenerative diseases and improvement of cognition and brain metabolism in cases of mild cognitive impairment. Alongside its integration into clinics, basic research studies have elucidated HBOT’s mechanisms of action and its effects on cellular processes, transcription factors, mitochondrial function, oxidative stress, and inflammation. Therefore, HBOT is becoming a major player in 21st century research and clinical treatments. The following review will discuss the basic mechanisms of HBOT, and its effects on cellular processes, cognition, and brain disorders.

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“…HBO has a dynamic effect on a diverse stem cell population in vivo. Strikingly, HBO may increase total accessible endogenous stem cells by raising many circulating stem cells in a pressure-susceptive manner(Zhang et al 2021 ) and by upregulating the proliferation of NSCs within their neurogenic niches in the adult brain. The mechanism of HBO in NSC proliferation might involve the upregulation of crucial regulatory molecules, such as its receptor (VEGFR2), vascular endothelial growth factor (VEGF) (HIF-1α downstream target), ERK, and CREB(Liska et al 2018 ).…”

Section: Potential Mechanism Of Hbo-pc For Ismentioning

confidence: 99%

An overview of hyperbaric oxygen preconditioning against ischemic stroke

You

Chen

et al. 2023

Metab Brain Dis

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Ischemic stroke (IS) has become the second leading cause of morbidity and mortality worldwide, and the prevention of IS should be given high priority. Recent studies have indicated that hyperbaric oxygen preconditioning (HBO-PC) may be a protective nonpharmacological method, but its underlying mechanisms remain poorly defined. This study comprehensively reviewed the pathophysiology of IS and revealed the underlying mechanism of HBO-PC in protection against IS. The preventive effects of HBO-PC against IS may include inducing antioxidant, anti-inflammation, and anti-apoptosis capacity; activating autophagy and immune responses; upregulating heat shock proteins, hypoxia-inducible factor-1, and erythropoietin; and exerting protective effects upon the blood-brain barrier. In addition, HBO-PC may be considered a safe and effective method to prevent IS in combination with stem cell therapy. Although the benefits of HBO-PC on IS have been widely observed in recent research, the implementation of this technique is still controversial due to regimen differences. Transferring the results to clinical application needs to be taken carefully, and screening for the optimal regimen would be a daunting task. In addition, whether we should prescribe an individualized preconditioning regimen to each stroke patient needs further exploration.

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Hyperbaric oxygen therapy mobilized circulating stem cells and improved delayed encephalopathy after acute carbon monoxide poisoning with up-regulation of brain-derived neurotrophic factor

Cited by 11 publications

References 34 publications

Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics

Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics

Hyperbaric Oxygen Treatment—From Mechanisms to Cognitive Improvement

An overview of hyperbaric oxygen preconditioning against ischemic stroke

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