“…HBOT has been described as an adjunctive treatment for adults with HS . There is one recent report of HBOT improving the efficacy of adalimumab therapy in an adult with HS . To our knowledge, our patient represents the first pediatric case successfully treated with HBOT and high‐dose ustekinumab for severe HS.…”
Hidradenitis suppurativa is a painful chronic inflammatory skin condition characterized by inflammatory nodules that can lead to sinus tracts and scarring. Numerous treatments have been reported, though none have reliable efficacy. Anti inflammatory agents, such as tumor necrosis factor-alpha inhibitors and interleukin inhibitors, have been used as medical therapy for refractory cases. We describe here a case of severe hidradenitis suppurativa in a pediatric patient successfully treated with a combination of high-dose ustekinumab and hyperbaric oxygen therapy.
“…HBOT has been described as an adjunctive treatment for adults with HS . There is one recent report of HBOT improving the efficacy of adalimumab therapy in an adult with HS . To our knowledge, our patient represents the first pediatric case successfully treated with HBOT and high‐dose ustekinumab for severe HS.…”
Hidradenitis suppurativa is a painful chronic inflammatory skin condition characterized by inflammatory nodules that can lead to sinus tracts and scarring. Numerous treatments have been reported, though none have reliable efficacy. Anti inflammatory agents, such as tumor necrosis factor-alpha inhibitors and interleukin inhibitors, have been used as medical therapy for refractory cases. We describe here a case of severe hidradenitis suppurativa in a pediatric patient successfully treated with a combination of high-dose ustekinumab and hyperbaric oxygen therapy.
“…Infundibular hyperkeratosis with subsequent follicular plugging in intertriginous skin areas may result in ductal hypoxia, an HIF-1 -induced comedogenic mechanism earlier suggested in acne pathogenesis [ 117 , 118 ]. In fact, hyperbaric oxygen treatment (HBOT) improves HS and enhances the efficacy of adalimumab and ustekinumab [ 119 – 121 ]. In selected experimental models, HBOT decreased the expression of HIF-1 [ 122 – 124 ].…”
Hypoxia-inducible factor-1α (HIF-1α) is the master transcription factor of glycolysis, Th17 cell differentiation and suppression of regulatory T cells. In the skin and serum of patients with psoriasis vulgaris, increased expression of HIF-1α has been reported, whereas HIF-1α expression in the skin and serum of patients with hidradenitis suppurativa (HS) has not yet been studied. The objective of the study is to demonstrate is there a role for HIF-1α in the pathogenesis of hidradenitis suppurativa, and its relation to HS severity. Twenty patients suffering from hidradenitis suppurativa were included in the study. Punch biopsies were taken from lesional skin for the determination of HIF-1α expression by immunohistochemical staining, and HIF-1α gene expression by quantitative reverse transcription real time PCR. Quantification of HIF-1α protein concentration was done by enzyme-linked immunosorbent assay. Twenty socio-demographically cross-matched healthy volunteers served as controls. We found increased serum levels of HIF-1α. Literature-derived evidence indicates that the major clinical triggering factors of HS, obesity, and smoking are associated with hypoxia and enhanced HIF-1α expression. Pro-inflammatory cytokines such as tumor necrosis factor-$$a$$
a
via upregulation of nuclear factor $$\kappa$$
κ
B enhance HIF-1α expression. HIF-1α plays an important role for keratinocyte proliferation, especially for keratinocytes of the anagen hair follicle, which requires abundant glycolysis providing sufficient precursors molecules for biosynthetic pathways. Metformin via inhibition of mTORC1 as well as adalimumab attenuate HIF-1α expression, the key mediator between Th17-driven deviated immunity and keratinocyte hyperproliferation. In accordance with psoriasis, our study identifies HS as an HIF-1α-driven inflammatory skin disease and offers a new rationale for the prevention and treatment of HS by targeting HIF-1$$a$$
a
overexpression.
“…A Chinese woman with a severe vasculitis ulcer was treated with rituximab, methotrexate, and HBO, and the ulcer was improved ( 103 ). In addition, HBO can increase the curative effect of adalimumab in hidradenitis suppurativa ( 104 ). We found that HBO can increase the efficacy of antibody therapy in diseases.…”
Section: Hyperbaric Oxygen and Other Immunotherapymentioning
Hyperbaric oxygen therapy is a relatively safe treatment method that has been used for a long time in the clinic. It has been proven that it can enhance the sensitivity of radiotherapy and photodynamic therapy for cancer. However, there are few studies on hyperbaric oxygen and immunotherapy. In this article, we summarize that hyperbaric oxygen therapy regulates the tumor microenvironment through various pathways such as improving tumor hypoxia, targeting hypoxia-inducing factors, and generating reactive oxygen species. The change in the tumor microenvironment ultimately affects the curative effect of immunotherapy. Therefore, hyperbaric oxygen can influence immunotherapy by regulating the tumor microenvironment, providing a direction for the future development of immunotherapy.
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