Hyperbaric oxygen therapy as a prevention modality for radiation damage in the mandibles of mice

Spiegelberg, Linda; Braks, Joanna A. M.; Groeneveldt, Lisanne C.; Djasim, Urville M.; Wal, K.G.H. van der; Wolvius, Eppo B.

doi:10.1016/j.jcms.2014.11.008

Cited by 7 publications

(10 citation statements)

References 31 publications

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“…Literature on the effect of HBO on bone turnover and micro-architecture in irradiated mandibles is scarce though, and solely reported from animal studies. Spiegelberg et al demonstrated that HBO therapy positively influenced the micro-architectural parameters of irradiated mandibular cancellous bone in mice (Spiegelberg et al, 2015). HBO completely normalized values for BV/TV, trabecular separation, trabecular thickness and porosity in irradiated bone, but trabecular number remained significantly increased in irradiated bone.…”

Section: Discussionmentioning

confidence: 99%

Bone microarchitecture and turnover in the irradiated human mandible

Dekker

Schulten

Ruijven

et al. 2020

Journal of Cranio-Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Bone microarchitecture and turnover in the irradiated human mandible

Dekker

Schulten

Ruijven

et al. 2020

Journal of Cranio-Maxillofacial Surgery

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“…HBO 2 decreased the inflammation and accelerated the bone formation after acute injury to the femur in a rat model (Rocha et al , ). In a higher‐fidelity model of human ORN, a murine model of mandibular radiation damage found that HBO 2 improved the parameters associated with bone health, including decreased osteoclast numbers, increased bone viability, and increased bone volume (Spiegelberg et al , ). HBO 2 may also lead to increased testosterone levels (Passavanti et al , ) that could affect the bone health.…”

Section: Hbo2 Mechanistic Datamentioning

confidence: 99%

Hyperbaric oxygen therapy and osteonecrosis

et al. 2016

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Osteonecrosis of the jaw may be caused by radiation, medication, or infection. Optimal therapy requires a multimodal approach that combines surgery with adjuvant treatments. This review focuses on the use of adjunctive hyperbaric oxygen therapy for this condition. In addition to evidence regarding the basic and clinical science behind hyperbaric oxygen therapy, controversies in the field and economic implications are discussed. Oral Diseases (2017) 23, 141-151

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“…Regarding the treatment of ORN, several methods have been suggested depending on the presence of a necrotic lesion, the response to conservative nonsurgical treatment, the patient's general health, the prognosis for successful treatment of cancer, the patient's wishes, the irradiation dose and the time interval between RT and ORN development (Epstein et al, 1987a, Notani et al, 2003, Spiegelberg et al, 2015. The treatment methods are divided into two main categories: conservative treatment (improvement of oral hygiene and administration of antibiotics, analgesics and HBO) and surgical treatment (Ioannides et al, 1994, Maurer et al, 2002, Raghoebar et al, 2005, KalantarHormozi and Khorvash, 2006.…”

Section: Treatment Of Ornmentioning

confidence: 99%