Hyperbaric oxygen therapy: Antimicrobial mechanisms and clinical application for infections

Memar, Mohammad Yousef; Yekani, Mina; Alizadeh, Naser; Baghi, Hossein Bannazadeh

doi:10.1016/j.biopha.2018.10.142

Cited by 144 publications

(125 citation statements)

References 98 publications

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“…Many DFUs fail to heal, and colonising microorganisms may play a role in this process. HBOT, in addition to its purported ulcer healing benefits, is also believed to have a variety of antimicrobial effects in soft tissue and bone . Thus, it is reasonable to consider whether or not adjunctive HBOT might help cure various types of DFIs.…”

Section: Treatmentmentioning

confidence: 99%

“…HBOT, in addition to its purported ulcer healing benefits, is also believed to have a variety of antimicrobial effects in soft tissue and bone. [165][166][167][168][169][170] In addition to systemic HBOT, high levels of oxygen can be delivered to a wound by local or topical methods. 174 Although various methods of topical oxygen therapy have been investigated for decades, there are only a few published case reports in patients and insufficient evidence to support using this form of adjunctive treatment to address infection.…”

Section: Rationalementioning

confidence: 99%

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Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Lipsky

Senneville

Abbas

et al. 2020

Diabetes Metabolism Res

501

729

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The International Working Group on the Diabetic Foot (IWGDF) has published evidence‐based guidelines on the prevention and management of diabetic foot disease since 1999. This guideline is on the diagnosis and treatment of foot infection in persons with diabetes and updates the 2015 IWGDF infection guideline. On the basis of patient, intervention, comparison, outcomes (PICOs) developed by the infection committee, in conjunction with internal and external reviewers and consultants, and on systematic reviews the committee conducted on the diagnosis of infection (new) and treatment of infection (updated from 2015), we offer 27 recommendations. These cover various aspects of diagnosing soft tissue and bone infection, including the classification scheme for diagnosing infection and its severity. Of note, we have updated this scheme for the first time since we developed it 15 years ago. We also review the microbiology of diabetic foot infections, including how to collect samples and to process them to identify causative pathogens. Finally, we discuss the approach to treating diabetic foot infections, including selecting appropriate empiric and definitive antimicrobial therapy for soft tissue and for bone infections, when and how to approach surgical treatment, and which adjunctive treatments we think are or are not useful for the infectious aspects of diabetic foot problems. For this version of the guideline, we also updated four tables and one figure from the 2016 guideline. We think that following the principles of diagnosing and treating diabetic foot infections outlined in this guideline can help clinicians to provide better care for these patients.

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Section: Treatmentmentioning

confidence: 99%

Section: Rationalementioning

confidence: 99%

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Lipsky

Senneville

Abbas

et al. 2020

Diabetes Metabolism Res

501

729

View full text Add to dashboard Cite

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“…It was shown that the wound tissue oxygen tension predicted the risk of surgical site infections in post-operative patients [25]. Hyperbaric oxygen therapy has been used as a treatment for a variety of different infections, but the mechanisms are not completely understood [26].…”

Section: Infections In Hypoxic and Anaerobic Tissue Environmentsmentioning

confidence: 99%

Oxygen-Independent Antimicrobial Photoinactivation: Type III Photochemical Mechanism?

Hamblin

Abrahamse

2020

Antibiotics

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Since the early work of the 1900s it has been axiomatic that photodynamic action requires the presence of sufficient ambient oxygen. The Type I photochemical pathway involves electron transfer reactions leading to the production of reactive oxygen species (superoxide, hydrogen peroxide, and hydroxyl radicals), while the Type II pathway involves energy transfer from the PS (photosensitizer) triplet state, leading to production of reactive singlet oxygen. The purpose of the present review is to highlight the possibility of oxygen-independent photoinactivation leading to the killing of pathogenic bacteria, which may be termed the “Type III photochemical pathway”. Psoralens can be photoactivated by ultraviolet A (UVA) light to produce DNA monoadducts and inter-strand cross-links that kill bacteria and may actually be more effective in the absence of oxygen. Tetracyclines can function as light-activated antibiotics, working by a mixture of oxygen-dependent and oxygen independent pathways. Again, covalent adducts may be formed in bacterial ribosomes. Antimicrobial photodynamic inactivation can be potentiated by addition of several different inorganic salts, and in the case of potassium iodide and sodium azide, bacterial killing can be achieved in the absence of oxygen. The proposed mechanism involves photoinduced electron transfer that produces reactive inorganic radicals. These new approaches might be useful to treat anaerobic infections or infections in hypoxic tissue.

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“…При COVID-19 ГБО-терапия может быть эффективна в отношении снижения уровня цитокинов (TNF-α, IL-1β, IL-6) [27][28][29], то есть минимизации степени «цитокинового шторма», и выраженности окислительного стресса [29][30][31], а также улучшения капиллярной пролиферации и ускорения включения коллатерального кровотока [32,33]. Кроме того, ГБО являлась действенной при инфекционных осложнениях, когда другие методы оказывались неэффективными [34][35][36]. инфекционных осложнениях, когда другие методы оказывались неэффективными [34][35][36].…”

Section: обсуж дениеunclassified

The Safety of Hyperbaric Oxygen Therapy in the Treatment of Covid-19

Левина¹,

Евсеев²,

Шабанов³

et al. 2020

Neotložnaâ med. pomoŝʹ

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Relevance. Acute respiratory infection COVID-19 caused by the SARS-CoV-2 (2019-nCov) coronavirus is severe and extremely severe in 15—20% of cases, which is accompanied by the need for respiratory support. Hyperbaric oxygenation is recognized as an effective therapy for replenishing any form of oxygen debt.Aim of study. To study the safety of HBO use in patients with COVID-19.Material and metods. We examined 32 patients with the diagnosis “Coronavirus infection caused by the virus SARS-CoV-2” (10 — moderately severe patients (CT 1–2), 22 — patients in serious condition (CT 3–4), who received course of hyperbaric oxygenation (HBO). The procedures were carried out in a Sechrist 2800 chamber (USA) at a mode of 1.4–1.6 AT for no more than 60 minutes. In total, the patients received 141 HBO sessions. Before and after each HBO session, the subjective indicators of the patient’s condition were assessed and the blood oxygen saturation was measured.Results. An algorithm for HBO course management was developed, which consists in using “soft” modes (up to 1.4 AT) during the first session, followed by pressure adjustment (not higher than 1.6 AT) during the course to achieve maximum therapeutic effect and comfort for the patient. Against the background of the HBO course, the patients showed an increase in blood oxygen saturation in patients in both surveyed groups, as well as positive dynamics in the form of a decrease in shortness of breath, an improvement in general well-being.Conclusion. The inclusion of daily sessions (at least 4) of hyperbaric oxygenation in “soft” modes (1.4–1.6 ATA) in the complex therapy for COVID-19 has shown its safety and preliminary positive effect on the subjective state of the examined patients and the dynamics of blood oxygen saturation.

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Hyperbaric oxygen therapy: Antimicrobial mechanisms and clinical application for infections

Cited by 144 publications

References 98 publications

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Oxygen-Independent Antimicrobial Photoinactivation: Type III Photochemical Mechanism?

The Safety of Hyperbaric Oxygen Therapy in the Treatment of Covid-19

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