Hyperbaric oxygen therapy accelerates vascularization in keratinized oral mucosal surgical flaps

Abstract

Our results suggest that HBOT is capable of advancing wound vascular regeneration in healing keratinized oral mucosal flaps.

Hyperbaric Oxygen Therapy for Wound Dehiscence After Intraoral Bone Grafting in the Nonirradiated Patient: A Case Series

“…9 Subsequently, more oxygenated blood can reach the wound, thereby maintaining the integrity of the healed tissue after the therapy sessions. 8,13 Bayati el al 14 reported a marked increase in the area of myocutaneous flap survival through improved vascularity using hyperbaric oxygen. Perrins 15 conducted a randomized controlled trial and found an overall 29% improvement in skin graft survival in the group treated with hyperbaric oxygen.…”

“…The intermittent application stimulates new vascularization in the affected tissue, as observed in oral mucosal flaps in rabbits. 8 Also, by increasing oxygen levels, white blood cell counts and fibroblast function improve. 9 Through these mechanisms, HBOT could be beneficial in nonirradiated patients with intraoral compromised wound healing.…”

A critical look at the effect of hyperbaric oxygen on the ischemic nipple following nipple sparing mastectomy and implant based reconstruction: a case series

“…Zamboni et al found using in vitro and in vivo animal studies that ischemiareperfusion injury was minimized through a nitric oxide mediated mechanism that resulted in decreased polarization of the CD18 on neutrophils (Zamboni2). Additionally, several animal studies have shown the benefit of HBOT in neovascularization of ischemic tissue flaps (27)(28)(29).…”

Impact of Breathing 100% Oxygen on Radiation-Induced Cognitive Impairment

“…However, there is a plethora of information on the biological effects of placing humans in hyperbaric oxygen (100% O 2 environment at 2.4–3.0 atm) for single or multiple 2 h treatments, with or without irradiation (37–39). Among the known benefits of hyperbaric oxygen therapy are: 1. improved tumor response to radiation therapy (37, 40, 41); 2. stimulation of cell renewal (42, 43); 3. increased growth of new blood vessels (43–46); 4. decreased inflammation (46, 47); 5. increased ability to fight infection (48); and 6. stimulation of collagen production (39, 49, 50). With the possible exception of decreased neuroinflammation, none of these should positively affect radiation-induced cognitive impairment after breathing 100% O 2 for a single 2.5 h period.…”