Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery

Abstract

HBO at 3 atmospheres absolute reduced infarct volume by increasing oxygen supply to the ischemic periphery without aggravating lipid peroxidation, suggesting that HBO can be useful in treating stroke victims.

Hyperbaric Oxygen Combined With Intravenous Edaravone for Treatment of Acute Embolic Stroke: a Pilot Clinical Trial

“…18) Also, breathing 100% oxygen after 15 minutes of global brain ischemia not followed by reperfusion increased lipid peroxidation and mortality in gerbils. 11) On the other hand, HBO did not increase brain lipid peroxidation if administered to rats after 10 minutes of focal brain ischemia not followed by reperfusion, 24) and HBO increased free radicals but not lipid peroxidation if started within 1 minute of reperfusion following cerebral ischemia in a rabbit model. 12) Therefore, we suspect that HBO probably increases free radicals and lipid peroxidation, particularly in patients with embolic stroke in whom recanalization commonly occurs at various times.…”

“…Hyperbaric oxygen (HBO) therapy for acute cerebral ischemia has been evaluated by animal experiments 5,12,18,24) and human clinical observations. 3,8,10,13,15,20) The experimental studies suggested considerable potential, 5,12,18,24) but the clinical effectiveness in patients with acute ischemic stroke has been controversial.…”

“…3,8,10,13,15,20) The experimental studies suggested considerable potential, 5,12,18,24) but the clinical effectiveness in patients with acute ischemic stroke has been controversial. With the exception of three studies, 3,15,20) the major criticism of most clinical investigations has been the lack of controlled prospective analysis.…”

Hyperbaric oxygen solution infused into the anterior interventricular vein at reperfusion reduces infarct size in swine

“…The concept of reducing infarct size by delivering hyperbaric levels of oxygen to the heart has been pursued for many years. The initial approach used hyperbaric chambers (21,25,26,27,31). In most of the animal experiments, hyperbaric chamber treatment was performed during the ischemic phase and showed a reduction in infarct size.…”

“…Hyperbaric oxygen has been shown to reduce ischemic myocardial injury in experimental and clinical studies (21,25,26,27,31). Initial work using hyperbaric oxygen chambers showed efficacy to salvage myocardium but have limited practical applicability.…”