Hyperbaric oxygen solution infused into the anterior interventricular vein at reperfusion reduces infarct size in swine

Johnson, Lynne L.; Schofield, Lorraine; Bouchard, Mark; Chaves, Leonard; Poppas, Athena; Reinert, Steven E.; Zalesky, Paul; Creech, Jeffrey; Williams, David O.

doi:10.1152/ajpheart.00333.2003

Cited by 8 publications

(4 citation statements)

References 28 publications

(39 reference statements)

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“…Notwithstanding this, although this oversupply of O 2 may provide the principal explanation for our data immediately after HBO, the arterial tension, and probably the tissue tension, of oxygen returned to normal values at the end of depressurization; hence, the findings at 24 h must be due to other mechanisms involving HBO. In fact, other mechanisms have been proposed as accounting for the favourable effects of HBO in different ischaemic situations, including a reduction in apoptosis and oxidative stress, 25 inhibition of arteriolar vasoconstriction and venular leucocyte adherence, 26 a reduction of neutrophil activation 27 and an increase in the expression and activity of catalase 7 . In addition, HBO can modulate the oxidative reactions that are important contributors to cardiomyocyte death 25 and stimulates nitric oxide production via an interaction between nitric oxide synthase and heat shock protein 90 28–30 .…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygenation Applied Immediately After Coronary Occlusion Reduces Myocardial Necrosis and Acute Mortality in Rats

Santos¹,

Serra²,

Antônio³

et al. 2009

Clin Exp Pharma Physio

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1. Because in ischaemia there is a critical lack of O2, it has been reasoned that increasing O2 delivery to the ischaemic myocardium could serve as adjunctive therapy for acute myocardial infarction (MI). Accordingly, in the present study, the effect of early hyperbaric oxygenation (HBO) on mortality and MI size after coronary occlusion was examined in rats. 2. After coronary occlusion, male Wistar rats were randomly assigned to receive either HBO for 1 h in a hyperbaric chamber (100% O(2) at 253 kPa; n = 106) or ambient O2 as the control (n = 111). The extent of myocardial necrosis was assessed (triphenyltetrazolium) immediately after treatment in the HBO (n = 50) and control (n = 47) groups. The remaining rats were evaluated 24 h after occlusion to enable calculation of MI size and mortality. 3. Immediately after therapy, the size of the MI was significantly greater in the control group compared with that in the HBO group (40 +/- 3 vs 27 +/- 2% of the left ventricle (LV), respectively; P < 0.001). The 24 h mortality of control rats was higher than that of HBO rats (34 vs 16%, respectively; P = 0.02). Control rats that survived 24 h had a larger MI than did HBO rats that survived 24 h (40 +/- 4 vs 29 +/- 3% of the LV, respectively; P = 0.005). Furthermore, large necrotic areas (> 40% of the LV) were more frequent in control than HBO rats (55 vs 27% of infarcted hearts, respectively; P = 0.01). There was less pulmonary congestion observed in HBO rats compared with control rats. 4. In conclusion, early therapy with HBO during the onset of an acute ischaemic event decreases the necrotic area and reduces acute mortality. These data support further investigation of HBO as an adjuvant therapy for acute MI.

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Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygenation Applied Immediately After Coronary Occlusion Reduces Myocardial Necrosis and Acute Mortality in Rats

Santos¹,

Serra²,

Antônio³

et al. 2009

Clin Exp Pharma Physio

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“…The statistically significant, marked reduction in tissue myeloperoxidase levels, a quantitative measure of neutrophil counts,146 in the reperfused myocardium treated with SSO 2 compared to control groups in two independent models of myocardial infarction117,118 suggests that inflammation was reduced experimentally by the treatment. If ROS had been increased by SSO 2 , one would have expected evidence of more inflammation 147.…”

Section: Oxygen Radicalsmentioning

confidence: 99%

“…may have already occurred prior to treatment. Indeed, Johnson et al118 showed experimentally that immediate perfusion with SSO 2 post coronary ischemia via a retrograde coronary venous route was more effective in infarct size reduction compared to similar treatment following a 30-mins period of reperfusion.…”

Section: Limitationsmentioning

confidence: 99%

“…In a canine model of regional low flow myocardial ischemia, intracoronary SSO 2 infusion prevented the fall in echo LVEF associated with normoxemic low flow perfusion 94. The potential benefits of intracoronary SSO 2 infusion for acutely enhancing post MI reperfusion in animal models were described by Spears et al115–117 and Johnson et al,118 and reviewed by Glazier119 and Bartorelli 120. A 90-mins treatment, initiated 15–30 mins after the onset of reperfusion following a 60–90 mins coronary occlusion, was associated with normalization of left ventricular ejection fraction (LVEF) compared to no improvement of this parameter in control groups.…”

Section: Introductionmentioning

confidence: 96%

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<p>Reperfusion Microvascular Ischemia After Prolonged Coronary Occlusion: Implications And Treatment With Local Supersaturated Oxygen Delivery</p>

Spears¹

2019

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Following a prolonged coronary arterial occlusion, heterogeneously scattered, focal regions of low erythrocyte flow are commonly found throughout the reperfused myocardium. Experimental studies have also demonstrated the presence of widespread, focally patchy regions of microvascular ischemia during reperfusion (RMI). However, the potential contribution of RMI to tissue viability and function has received little attention in the absence of practical clinical methods for its detection. In this review, the anatomic/functional basis of RMI is summarized, along with the evidence for its presence in reperfused myocardium. Advances in microcirculation research related to obstructive responses of vascular endothelial cells and blood elements to the effects of hypoxia and low shear stress are discussed, and a potential cycle of intensification of RMI from such responses and progressive loss of functional capillary density is presented. In capillaries with impaired erythrocyte flow, compensatory increases in the delivery of oxygen, because of its low solubility in plasma, are effective only at high partial pressures. As discussed herein, attenuation of the cycle with oxygen at hyperbaric levels in plasma is, very likely, responsible for improved tissue level perfusion noted experimentally. Observed clinical benefits from intracoronary SuperSaturated oxygen (SSO2) delivery, including infarct size reduction, can be attributed to attenuation of RMI with improvement in microvascular blood flow.

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Aqueous Oxygen for Treatment of ST‐Segment Elevation Myocardial Infarction

Katukuri

Creech²,

Spears

2014

Urgent Interventional Therapies

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Hyperbaric oxygen solution infused into the anterior interventricular vein at reperfusion reduces infarct size in swine

Abstract: . Hyperbaric oxygen solution infused into the anterior interventricular vein at reperfusion reduces infarct size in swine.

Cited by 8 publications

References 28 publications

Hyperbaric Oxygenation Applied Immediately After Coronary Occlusion Reduces Myocardial Necrosis and Acute Mortality in Rats

Hyperbaric Oxygenation Applied Immediately After Coronary Occlusion Reduces Myocardial Necrosis and Acute Mortality in Rats

<p>Reperfusion Microvascular Ischemia After Prolonged Coronary Occlusion: Implications And Treatment With Local Supersaturated Oxygen Delivery</p>

Aqueous Oxygen for Treatment of ST‐Segment Elevation Myocardial Infarction

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