Hyperbaric oxygen preconditioning promotes angiogenesis in rat liver after partial hepatectomy

Ren, Ping; Kang, Zhiming; Gu, GuoJun; Liu, Yun; Xu, Wei; Tao, Hengyi; Zhang, Junyi; Sun, Xuejun; Ji, Hui

doi:10.1016/j.lfs.2008.06.011

Cited by 35 publications

(30 citation statements)

References 43 publications

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“…These activities are related to the pathological cascade of free radical reactions and further yielded to more reactions that are responsible for impairing the cellular structure and function. [36][37][38] Prior investigations have confirmed that HBO can protect against IRI; here, we postulated that it may achieve its beneficial effects by preserving high-energy compounds, 1 limiting hypoxic-ischemic-induced lipid peroxidation, 14 and modifying the inflammatory process. 7 HBO has been used as an adjunctive therapy for several I/R injuries, including acute peripheral ischemia and myocardial infarction.…”

Section: Discussionmentioning

confidence: 92%

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Hyperbaric oxygen therapy protects the liver from apoptosis caused by ischemia‐reperfusion injury in rats

et al. 2009

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Section: Discussionmentioning

confidence: 92%

“…33 The caspase cleavage is a reliable and validated apoptosis marker for IRI tissue. [28][29][30][31] HBO is effective in protecting these tissues against IRI, [34][35][36][37][38] though the mechanism is not fully understood. 9 Exposure to HBO decreases the reaction to the oxidative stress and inhibits cytokines.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen therapy protects the liver from apoptosis caused by ischemia‐reperfusion injury in rats

et al. 2009

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“…In addition, some studies have also shown that HBO therapy can improve the angiogenesis after ischemic injury. Our previous study also revealed that HBO pretreatment can increase the expression of hypoxia-inducible factor and its downstream factor vascular endothelial growth factor [2] which is a potent pro-angiogenic factor. Thus, HBO seems to exert promotive effect on cancer growth.…”

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confidence: 84%

Hyperbaric oxygen and cancer: more complex than we expected

et al. 2013

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Hyperbaric oxygen (HBO) therapy refers to the breathing of pure oxygen while in a sealed chamber that has been pressurized at 1.5 to 3 times normal atmospheric pressure. To date, HBO therapy has been applied in a series of diseases with potential hypoxia including decompression sickness, carbon monoxide poisoning, gas gangrene, osteomyelitis, and so on (http://en.wikipedia.org/wiki/Hyperbaric_medicine). However, cancer is not an indication for hyperbaric oxygen in both USA and China.Recently, Moen and Stuhr reviewed the evidence on the influence of HBO on cancers in past 9 years [1]. Their conclusion was consistent with two previous systemic reviews on HBO and cancer that the use of HBO in patients with malignancies is considered safe. In this review, they summarized the relationship between hypoxia and cancer and the influence of HBO on cell survival, angiogenesis, metastasis, chemotherapy, and radiotherapy. Finally, they reviewed the effect of HBO on cancer cells of different types. Although they proposed some explanations on the effects of HBO on cancers, the mechanisms are more complex than we expected. HBO, hypoxia, and angiogenesisIt has been accepted that HBO can increase the dissolved oxygen significantly, which may rectify the hypoxia in cancers. However, HBO is often used once or twice daily for patients, and a hypoxic environment may form between two exposures. As shown in this review, hypoxia is essential for the progression of cancers and related to the angiogenesis. In addition, some studies have also shown that HBO therapy can improve the angiogenesis after ischemic injury. Our previous study also revealed that HBO pretreatment can increase the expression of hypoxia-inducible factor and its downstream factor vascular endothelial growth factor [2] which is a potent pro-angiogenic factor. Thus, HBO seems to exert promotive effect on cancer growth. HBO and metastasisMetastasis is a complex process involving local cancer cell invasion, entry into the blood or lymph vessels, and repenetration and colonization at a distant site [3]. The integrity of vascular basement membrane (VBM) is crucial for the cancer cell invasion. Suzuki et al. found that HBO enhanced transendothelial permeability in rat brains [4]. In addition, HBO preconditioning was found to increase the expression of matrix metalloproteinase (MMP) [5] which is may break the VBM. This may potentiate the cancer cell invasion. Of interest, HBO therapy may reduce the insult-induced expression of MMP [6]. Thus, whether the effect of HBO on VBM integrity depends on the microenvironment is not clear. If so, this may partially explain the absence of influence of HBO on the metastasis of cancers. HBO and cancer stem cellsCancer stem cells (CSCs) are cancer cells that possess characteristics associated with normal stem cells, specifically

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“…Ren et al 80 demonstrated that even though HBO preconditioning increased the number of new cells and the density of microcirculation in the regenerating liver, its effect on vascular endothelial growth factor was limited and its action did not translate into wet liver weight. Yu et al 81 performed a similar experimental study in rats.…”

Section: Other Types Of Preconditioningmentioning

confidence: 99%

Ischemia/reperfusion injury in liver resection: A review of preconditioning methods

et al. 2011

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Ischemic preconditioning is one of the therapeutic interventions aiming at preventing ischemia/reperfusion-related injury. Numerous experimental studies and a few clinical series have shown that during liver resections, ischemic preconditioning is a promising strategy for optimizing the postoperative outcome. Moreover, various types of pharmacological intervention as well as different types of preconditioning, such as remote preconditioning, the use of heat shock, and hyperbaric oxygen, have been developed to attenuate the functional impairment accompanying ischemia/reperfusion injury. This review summarizes the various forms of preconditioning, thus suggesting that close cooperation between surgeons and anesthesiologists paves the way to apply novel strategies to improve the outcome of liver resection.

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Hyperbaric oxygen preconditioning promotes angiogenesis in rat liver after partial hepatectomy

Cited by 35 publications

References 43 publications

Hyperbaric oxygen therapy protects the liver from apoptosis caused by ischemia‐reperfusion injury in rats

Hyperbaric oxygen therapy protects the liver from apoptosis caused by ischemia‐reperfusion injury in rats

Hyperbaric oxygen and cancer: more complex than we expected

Ischemia/reperfusion injury in liver resection: A review of preconditioning methods

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