Hyperbaric oxygen alone or combined with 5-FU attenuates growth of DMBA-induced rat mammary tumors

Stuhr, Linda Elin Birkhaug; Iversen, Vegard Vereide; Straume, Oddbjørn; Mæhle, Bjørn Ove; Reed, Rolf K.

doi:10.1016/j.canlet.2004.02.012

Cited by 43 publications

(43 citation statements)

References 16 publications

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“…There are now several lines of evidence showing that this is not the case [13]. The present work support previous conclusions from our group demonstrating that HBO has a significant inhibitory effect on mammary tumor growth in rats [14]. Also two studies on mice injected with various tumor cell lines exposed to 70% O 2 for 3 weeks showed a reduced number of lung colonies derived from mammary carcinoma MT-7 cells and of lung-tumor cell lines [17,18].…”

Section: Hbo Is Not a Tumor Promotersupporting

confidence: 89%

“…Our previous study at 2 bar, 100% O 2 significantly attenuated tumor growth in the same tumor model (included in Fig. 1) [14]. Taken together these results indicate a reduction in growth that is dosedependent on pO 2 .…”

Section: Tumor Growthsupporting

confidence: 74%

“…There are now several lines of evidence showing that this is not the case [13]. In a rat model of dimethyl-α-benz-anthracene (DMBA)-induced mammary adenocarcinomas, we have recently demonstrated a significant decrease in mammary tumor size after repeated HBO treatment at 2 bar for 90 minutes [14]. These paradoxical data indicate that an increase in the delivery of physically dissolved O 2 in the tumor tissue by hyperbaric hyperoxic treatment may suppress its growth.…”

Section: Introductionmentioning

confidence: 99%

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Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors

et al. 2007

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Section: Hbo Is Not a Tumor Promotersupporting

confidence: 89%

Section: Tumor Growthsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors

et al. 2007

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“…This may be related to the fact that the number of reports published on the efficacy of HBO in elevating the sensitivity of tumors to chemotherapy is less than that on the efficacy of HBO in increasing responsiveness to radiotherapy. Among experimental studies, reports are available on the effects of HBO used in combination with fluorouracil (25,35) doxorubicin (26) paclitaxel (36) and other agents. However, only one clinical report on the combination of HBO and misonidazole (37) is available for this type of combined therapy.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma

Kawasoe

Yokouchi²,

Ueno³

et al. 2009

Oncol Rep

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Abstract. Although hyperbaric oxygen has been shown to enhance the efficacy of radiotherapy and chemotherapy for the treatment of several malignant tumors, the impact of hyperbaric oxygen on osteosarcoma has not yet been demonstrated. In this study, we investigated the efficacy of hyperbaric oxygen alone and in combination with an anticancer drug as an adjuvant to chemotherapy. In vitro, highly metastatic murine osteosarcoma cell lines were exposed to hyperbaric oxygen and cell viability was examined. Hyperbaric oxygen alone significantly suppressed cell proliferation, and hyperbaric oxygen plus carboplatin exhibited significant synergism in suppression of cell proliferation. In vivo, C3H mice were subcutaneously inoculated with osteosarcoma cells and divided into four groups: control, hyperbaric oxygen, carboplatin, and carboplatin plus hyperbaric oxygen. After 5 weeks, increase in both tumor volume and number of lung metastases was significantly suppressed in the hyperbaric oxygen group. Concomitant hyperbaric oxygen clearly enhanced the chemotherapeutic effects of carboplatin on both tumor growth and lung metastasis in osteosarcoma-bearing mice. Moreover, mortality in the carboplatin plus hyperbaric oxygen group was significantly lower than in the other three groups. These findings suggest that hyperbaric oxygen plus carboplatin combination therapy could be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma.

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“…shortest and longest diameter of the tumors were measured. The volume of the tumor was calculated as: π / 6(a) 2 * (b), where a is the smallest and b is the longest length of the tumor [25]. …”

Section: Measurement Of Tumor Volumementioning

confidence: 99%

Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague–Dawley rats

Mundhe

Kumar

Ahmed

et al. 2015

International Immunopharmacology

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Hyperbaric oxygen alone or combined with 5-FU attenuates growth of DMBA-induced rat mammary tumors

Cited by 43 publications

References 16 publications

Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors

Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors

Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma

Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague–Dawley rats

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