2009
DOI: 10.1111/j.1471-0528.2009.02383.x
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Hyperandrogenaemia in adolescent girls: origins of abnormal gonadotropin‐releasing hormone secretion

Abstract: Polycystic ovarian syndrome is a common disorder characterised by ovulatory dysfunction and hyperandrogenaemia. Its origins begin peripubertally, as adolescent hyperandrogenaemia commonly leads to adult hyperandrogenaemia and decreased fertility. Hyperandrogenaemia reduces the inhibition of gonadotropin-releasing hormone pulse frequency by progesterone, causing rapid luteinising hormone pulse secretion and further increasing ovarian androgen production. Obese girls are at risk for hyperandrogenaemia and develo… Show more

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Cited by 46 publications
(41 citation statements)
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“…About 24% PCOS women were hirsute and 8% showed symptoms of acne. An increased conversion of testosterone to dihydrotestosterone via the enzyme 5 alpha reductase (5α-R) within the pilosebaceous unit may be one of the root causes for hirsutism [24] . 5-α reductase acts as an amplifier of the androgen signal [25] .…”
Section: Table 6: Multivariate Logistic Regression Analysis On Associmentioning
confidence: 99%
“…About 24% PCOS women were hirsute and 8% showed symptoms of acne. An increased conversion of testosterone to dihydrotestosterone via the enzyme 5 alpha reductase (5α-R) within the pilosebaceous unit may be one of the root causes for hirsutism [24] . 5-α reductase acts as an amplifier of the androgen signal [25] .…”
Section: Table 6: Multivariate Logistic Regression Analysis On Associmentioning
confidence: 99%
“…Excess LH secretion in PCOS is partly related to relative GnRH pulse generator resistance to the negative feedback actions of progesterone (Burt Solorzano et al 2010). This defect is reversed in adult PCOS by the androgen-receptor blockade (Eagleson et al 2000), suggesting that hyperandrogenemia per se contributes to abnormal neuroendocrine function in PCOS.…”
Section: Obesity and Hyperandrogenemia In Peripubertal Girlsmentioning
confidence: 99%
“…These data raise the possibility that dysfunctional coordination of the KNDy network may underlie neuroendocrine defects in clinical reproductive disorders, including PCOS . Adolescents with PCOS show disruption in the regulation of the GNRH pulse generator, characterized by rapid LH pulse frequency (Burt Solorzano et al 2010). To date, the limited investigations have focused on the early neurobiological mechanisms underlying pubertal regulation of the GNRH/LH pulsatile release by kisspeptin and NKB in adolescents with PCOS.…”
Section: Introductionmentioning
confidence: 99%