Obesity and the pubertal transition in girls and boys

Solorzano, Christine M. Burt; McCartney, Christopher R.

doi:10.1530/rep-10-0119

Cited by 355 publications

(335 citation statements)

References 99 publications

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“…The excess of fat in abdominal region is recognized, mainly, with risk factor to cardiovascular disease, diabetes, dyslipidemia and metabolic syndrome 31,32 .…”

Section: Discussionmentioning

confidence: 99%

Insatisfação corporal em escolares de uma cidade do Sul do Brasil

Leite

Ferrazzi

Mezadri

et al. 2014

J. Hum. Growth Dev.

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A insatisfação corporal associa-se a transtornos alimentares, dificuldades de relacionamento interpessoal e ideação suicida. Objetivou-se estimar a prevalência de insatisfação corporal, e verificar sua associação com variáveis infantis e maternas de escolares do 4º e 5º ano de escolas municipais de Itajaí, Santa Catarina. Sorteou-se 737 escolares, de 22 escolas urbanas e rurais. A coleta de dados compreendeu a coleta de dados antropométricos, aplicação de questionários para a criança e para seu responsável. A insatisfação corporal foi identificada, pela diferença entre a percepção da silhueta atual e àquela desejada pelos escolares. Calcularam-se as Razões de Prevalência (RP) e Intervalos de Confiança de 95% (IC 95%). A taxa de resposta foi 81,7% (n = 602). A prevalência de insatisfação corporal foi de 76,9%. Escolares acima do peso, e aqueles com excesso de gordura abdominal apresentaram prevalência 21% e 30%, superiores de insatisfação corporal. Filhos de pais com excesso de peso apresentaram prevalência 12% maior. Tentativas de emagrecer ou engordar foi 23% e 21% maior entre as crianças insatisfeitas com o peso. Após análise ajustada a prevalência foi menor entre as meninas (RP 0,9 IC95% 0,8;1,0) e maior entre crianças com excesso de gordura abdominal e que realizaram tentativas de perder ou ganhar peso (RP 1,2 IC95% 1,1; 1,4). Osresultados indicaram elevada prevalência de insatisfação corporal, principalmente entre os meninos. Aproximadamente metade dos escolares desejou peso inferior, contudo, entre os meninos o desejo de ganhar peso foi maior. A gordura na região abdominal associou-se fortemente à maior prevalência de insatisfação corporal.

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“…The excess of fat in abdominal region is recognized, mainly, with risk factor to cardiovascular disease, diabetes, dyslipidemia and metabolic syndrome 31,32 .…”

Section: Discussionmentioning

confidence: 99%

Insatisfação corporal em escolares de uma cidade do Sul do Brasil

Leite

Ferrazzi

Mezadri

et al. 2014

J. Hum. Growth Dev.

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“…Data on age-related changes in obesity has led some researchers to postulate that obesity could be considered as a condition of premature metabolic dysfunction resembling ageing (Tchkonia et al 2010;Burt Solorzano and McCartney 2010;Niemann et al 2011). Other studies claim that molecular pathways of regulation involved in obesity and ageing are divergent and specific or at least not overlapping (Miard and Picard 2008).…”

Section: Ageingmentioning

confidence: 99%

Obesity and related consequences to ageing

Jura

Kozak

2016

AGE

339

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Obesity has become a major public health problem. Given the current increase in life expectancy, the prevalence of obesity also raises steadily among older age groups. The increase in life expectancy is often accompanied with additional years of susceptibility to chronic ill health associated with obesity in the elderly. Both obesity and ageing are conditions leading to serious health problems and increased risk for disease and death. Ageing is associated with an increase in abdominal obesity, a major contributor to insulin resistance and the metabolic syndrome. Obesity in the elderly is thus a serious concern and comprehension of the key mechanisms of ageing and age-related diseases has become a necessary matter. Here, we aimed to identify similarities underlying mechanisms related to both obesity and ageing. We bring together evidence that age-related changes in body fat distribution and metabolism might be key factors of a vicious cycle that can accelerate the ageing process and onset of age-related diseases.

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“…Puberty is a maturation period in human development, when sexual characteristics and reproductive competence are developed (8). It is characterized by changes in the dynamically regulated hypothalamic-growth hormone (GH)-insulin-like growth factor (IGF)-1 and hypothalamic-pituitary-gonadal axes (9).…”

mentioning

confidence: 99%

Antioxidation improves in puberty in normal weight and obese boys, in positive association with exercise-stimulated growth hormone secretion

et al. 2015

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Background:Oxidative stress is associated with obesity while the evidence for the role of GH in pro-and antioxidation is inconclusive. This study investigates the relationships between growth hormone (GH), pro-and antioxidation in relation to obesity and puberty before and after an acute bout of exercise. Methods: In this case-control study, 76 healthy normalweight and obese, prepubertal and pubertal boys underwent a blood sampling before and immediately after an aerobic exercise bout until exhaustion at 70% maximal oxygen consumption. Markers of prooxidation (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCs)) and antioxidation (glutathione (GSH), oxidized glutathione disulfide (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPX), catalase, and total antioxidant capacity (TAC)) and hormones (GH, insulinlike growth factor (IGF)-1, IGF-BP-3, luteinizing hormone, follicle-stimulating hormone, and testosterone) were measured. results: Baseline and postexercise TBARS and PCs were greater, while baseline GSH, GSH/GSSG ratio, GPX, and TAC were lower in obese than that in normal-weight participants. In all participants, waist was the best negative and positive predictor for postexercise GPX and TBARS, respectively. Baseline TAC was greater in pubertal than that in pre-pubertal participants. In all participants, baseline GH was the best negative predictor for postexercise PCs. Significant positive linear correlation exists between the exercise-associated GH, and GSSG increases in pubertal normal-weight boys. conclusions: Higher prooxidation and lower antioxidation were observed in obese boys, while antioxidation improves with puberty and postexercise, paralleling GH accentuated secretion.o xidative stress defines a state of imbalance between proand antioxidation within the cell (1). Prooxidation refers to mitochondrial and nonmitochondrial mechanisms, which generate reactive oxygen and nitrogen species (RONS), whereas antioxidation refers to the adaptive activation of enzymatic and/ or nonenzymatic mechanisms, which scavenge prooxidants and their products within cells and in extracellular body fluids (1). Because the direct measurement of RONS is difficult to perform, thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCs) have been employed as markers of prooxidation (1). Glutathione (GSH) and oxidized glutathione disulfide (GSSG), the enzymes glutathione peroxidase (GPX) and catalase and the so-called total antioxidant capacity (TAC) have been employed as markers of antioxidation (2-4). Oxidative stress in humans has been associated with obesity and resulting comorbidities (1,5,6). Childhood obesity has been associated with oxidative stress even before comorbidities occur (6,7).Puberty is a maturation period in human development, when sexual characteristics and reproductive competence are developed (8). It is characterized by changes in the dynamically regulated hypothalamic-growth hormone (GH)-insulin-like growth factor (IGF)-1 and hypothalamic-pituitary-gonadal axes (9). ...

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Obesity and the pubertal transition in girls and boys

Cited by 355 publications

References 99 publications

Insatisfação corporal em escolares de uma cidade do Sul do Brasil

Insatisfação corporal em escolares de uma cidade do Sul do Brasil

Obesity and related consequences to ageing

Antioxidation improves in puberty in normal weight and obese boys, in positive association with exercise-stimulated growth hormone secretion

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