Hyper-fast gas chromatography and single-photon ionisation time-of-flight mass spectrometry with integrated electrical modulator-based sampling for headspace and online VOC analyses

Gehm, Christian; Schnepel, Kevin T.; Czech, Hendryk; Miersch, Toni; Ehlert, Sven; Zimmermann, Ralf

doi:10.1039/d1an00114k

Cited by 9 publications

(4 citation statements)

References 60 publications

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“…There was also the combination of GC × GC-TOF-MS and SIFT-MS for breath analysis [ 99 ]. Moreover, fast GC techniques are being developed that allow sufficiently short run times to be achieved that are in the range minutes to seconds, thus achieving close to real-time analysis [ 100 ].…”

Section: Discussionmentioning

confidence: 99%

Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body

et al. 2021

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Mass spectrometry (MS) is an analytical technique that can be used for various applications in a number of scientific areas including environmental, security, forensic science, space exploration, agri-food, and numerous others. MS is also continuing to offer new insights into the proteomic and metabolomic fields. MS techniques are frequently used for the analysis of volatile compounds (VCs). The detection of VCs from human samples has the potential to aid in the diagnosis of diseases, in monitoring drug metabolites, and in providing insight into metabolic processes. The broad usage of MS has resulted in numerous variations of the technique being developed over the years, which can be divided into hyphenated and real-time MS techniques. Hyphenated chromatographic techniques coupled with MS offer unparalleled qualitative analysis and high accuracy and sensitivity, even when analysing complex matrices (breath, urine, stool, etc.). However, these benefits are traded for a significantly longer analysis time and a greater need for sample preparation and method development. On the other hand, real-time MS techniques offer highly sensitive quantitative data. Additionally, real-time techniques can provide results in a matter of minutes or even seconds, without altering the sample in any way. However, real-time MS can only offer tentative qualitative data and suffers from molecular weight overlap in complex matrices. This review compares hyphenated and real-time MS methods and provides examples of applications for each technique for the detection of VCs from humans.

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Section: Discussionmentioning

confidence: 99%

Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body

et al. 2021

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“…In 2016, Jia and co-workers published the comparison of different EGA–PIMS platforms for studying biomass pyrolysis and concluded the problem of isomeric speciation solved in sophisticated SVUV approaches by scanning photon energies . Isomeric identification can also be addressed in the reactor or thermal analysis coupled to fast gas chromatography, which needs to be further explored in the future. ,, …”

Section: Future Research Directions and Perspectivesmentioning

confidence: 99%

“…138 Isomeric identification can also be addressed in the reactor or thermal analysis coupled to fast gas chromatography, which needs to be further explored in the future. 102,103,180 In the context of the increased usage of heavier fossil oil sources, including the analysis of heavy residues, such as vacuum gas oils or bitumen, as well as asphaltenes, the authors believe that vacuum direct inlet probe designs hold an enormous potential. Interestingly, this concept was prevalent almost half a century ago but might experience a comeback.…”

Section: ■ Future Research Directions and Perspectivesmentioning

confidence: 99%

Review on Evolved Gas Analysis Mass Spectrometry with Soft Photoionization for the Chemical Description of Petroleum, Petroleum-Derived Materials, and Alternative Feedstocks

et al. 2021

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Modern industry strongly relies on the molecular analysis of fossil petroleum and petroleum-derived materials. In the context of a circular economy and carbon neutrality, the chemical description of alternative feedstock materials, such as waste plastic and biomass pyrolysis oils, increases in importance. Moreover, online monitoring of the thermochemical and catalytic conversion processes has gained rising attention. In this framework, evolved gas analysis (EGA) concepts with soft photoionization mass spectrometry (PIMS) were successfully deployed for numerous challenges. On the one hand, photoionization is a highly versatile technique and allows for “soft” ionization of the analyte molecule, preserving the molecular information. On the other hand, multiple evolved gas analysis concepts exist with unique benefits, such as the mass loss information in thermogravimetry coupling, high-throughput in direct inlet probe concepts, or straightforward reactor monitoring, allowing for direct online insights into pyrolytic transformation processes. Hence, this review aims to summarize the recent work in the field of EGA–PIMS. After technical description of the multiple photoionization and thermal analysis concepts, applied studies are summarized, discussed, and evaluated. Besides fossil fuels, studies on alternatives from renewable materials, such as biomass pyrolysis, plastic pyrolysis oils, and recycling processes, are reviewed. Finally, future perspectives on this field are given, highlighting the importance of those soft ionization schemes together with state-of-the-art detection by high-resolution mass spectrometry in the field of energy and fuels research.

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“…Gas chromatography (GC) is widely used for the analysis of gaseous mixtures in various applications. [1][2][3] The stationary phases of most commercial GC columns, such as polymers 4 (i.e. HT-5, 5% phenyl, polycarborane siloxane; DB1, dimethylpolysiloxane) or porous solid absorbents, 5 are primarily based on their capability to selectively retain gaseous molecules.…”

Section: Introductionmentioning

confidence: 99%

A stamped aluminium gas chromatographic column disk employing directly grown anodic aluminium oxide stationary phase for the separation of aromatic and chlorinated compounds

Fan,

Wang,

2024

Analyst

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Hyper-fast gas chromatography and single-photon ionisation time-of-flight mass spectrometry with integrated electrical modulator-based sampling for headspace and online VOC analyses

Abstract: We developed a novel fast gas chromatography (fastGC) instrument with integrated sampling of volatile organic compounds (VOCs) and detection by single-photon ionisation (SPI) time-of-flight mass spectrometry (TOFMS).

Cited by 9 publications

References 60 publications

Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body

Hyphenated Mass Spectrometry versus Real-Time Mass Spectrometry Techniques for the Detection of Volatile Compounds from the Human Body

Review on Evolved Gas Analysis Mass Spectrometry with Soft Photoionization for the Chemical Description of Petroleum, Petroleum-Derived Materials, and Alternative Feedstocks

A stamped aluminium gas chromatographic column disk employing directly grown anodic aluminium oxide stationary phase for the separation of aromatic and chlorinated compounds

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