Hyper-Eosinophilic Syndrome Masquerading as Myocardial Infarction, Stroke and Cancer

Minupuri, Arun; Ramireddy, Karthik; Patel, Roshni; Hossain, Samia; Noain, Jesus Salas

doi:10.7759/cureus.9630

Cited by 4 publications

(3 citation statements)

References 11 publications

(13 reference statements)

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“…The differential diagnosis of EOS is broad, making the identification of its etiology challenging [ 1 ]. Primary care physicians have to be aware of the broad differential of peripheral eosinophilia in the routine clinical practice [ 10 ]. Careful history of past infections, medication exposure, residence or travel to geographic locations with parasitic endemics will provide the best evidence for individualized laboratory and imaging testing [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

A Young Male With Anorexia, Abdominal Complaints and Marked Blood Eosinophilia

Anyfantakis¹

2020

Cureus

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Section: Discussionmentioning

confidence: 99%

A Young Male With Anorexia, Abdominal Complaints and Marked Blood Eosinophilia

Anyfantakis¹

2020

Cureus

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“…We searched PubMed to identify case reports of stroke with HES and found 97 cases that have been reported from January 2000 to October 2021 [2] , [4] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , …”

Section: Introductionmentioning

confidence: 99%

Literature reviews of stroke with hypereosinophilic syndrome

Ono

Iwahana

Kato

et al. 2021

IJC Heart & Vasculature

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Hypereosinophilic syndrome (HES) is defined by persistently elevated blood eosinophil levels and is associated with evidence of organ damage. Cardiovascular involvement in HES is most commonly associated with Loffler endocarditis (cardiac HES). Cardiac HES is typically characterized by progressive subendocardial fibrosis with overlying mural thrombus formation, leading to restrictive dysfunction of the left ventricle. The thrombus from cardiac HES could result in cardiogenic stroke; however, most of the stroke cases with HES were not associated with huge thromboembolism rather multiple infarcts in the watershed area. The major clinical features of 97 previously reported cases of stroke with HES are as follows: the median age was 52 years, of which 61 (63%) were men; the initial presenting symptoms were neurological (73%), followed by headache (16%), respiratory symptoms (9%), and visual symptoms (9%). Almost half of the cases were diagnosed with cardiac HES. The characteristics of cardiac findings were mural thrombi, endomyocardial fibrosis, and a restrictive pattern of heart failure. Cerebral findings revealed 78 cases (80%) were described as multiple infarctions and 55 cases (57 %) were involved with watershed areas, whereas 11 cases (11％) were described as embolic stroke for one proximal large-vessel occlusion. Regarding treatment, 71 (73%), 28 (29%), and 16 (16%) patients were treated with steroids, anticoagulants, and antiplatelets, respectively. The overall mortality and recovery rates were 11% and 89%, respectively. Physicians should know most cases of stroke with HES are characterized by multiple infarctions in the watershed area, and cardiac HES is not always associated with stroke.

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“…This supports the opinion that eosinophils are strong inflammatory cells which, depending on the situation, are just as capable of damaging as they are of protecting their host. For example, hypereosinophilic syndrome is classified as a separate disease related to eosinophilia and tissue injury [ 5 ]. There is also considerable evidence of a relationship between the number or activity of eosinophils and the severity of inflammatory diseases such as asthma and chronic obstructive pulmonary disease [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Apoptosis of Eosinophil Granulocytes

Zustakova

Kratochvilova

Sláma

2020

Biology

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In the past 10 years, the number of people in the Czech Republic with allergies has doubled to over three million. Allergic pollen catarrh, constitutional dermatitis and asthma are the allergic disorders most often diagnosed. Genuine food allergies today affect 6–8% of nursing infants, 3–5% of small children, and 2–4% of adults. These disorders are connected with eosinophil granulocytes and their apoptosis. Eosinophil granulocytes are postmitotic leukocytes containing a number of histotoxic substances that contribute to the initiation and continuation of allergic inflammatory reactions. Eosinophilia results from the disruption of the standard half-life of eosinophils by the expression of mechanisms that block the apoptosis of eosinophils, leading to the development of chronic inflammation. Glucocorticoids are used as a strong acting anti-inflammatory medicine in the treatment of hypereosinophilia. The removal of eosinophils by the mechanism of apoptosis is the effect of this process. This work sums up the contemporary knowledge concerning the apoptosis of eosinophils, its role in the aforementioned disorders, and the indications for the use of glucocorticoids in their related therapies.

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Hyper-Eosinophilic Syndrome Masquerading as Myocardial Infarction, Stroke and Cancer

Cited by 4 publications

References 11 publications

A Young Male With Anorexia, Abdominal Complaints and Marked Blood Eosinophilia

A Young Male With Anorexia, Abdominal Complaints and Marked Blood Eosinophilia

Literature reviews of stroke with hypereosinophilic syndrome

Apoptosis of Eosinophil Granulocytes

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