Hymenolepis microstoma: Effect of the mouse bile duct tapeworm on the metabolic rate of CF-1 mice

Mayer, Larry; Pappas, Peter W.

doi:10.1016/0014-4894(76)90062-x

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…The massive hypertrophy associated with the immune response was confirmed (Table 2). Also, in agreement with Mayer & Pappas (1976), differences in body temperature, confirming increased metabolic rates, were not recorded for infected mice after 2 weeks p.i. The observed changes in lipogenesis measured in vivo could not therefore be ascribed simply to changes caused by increased body temperatures following infection.…”

Section: Body Temperaturesupporting

confidence: 84%

“…(Moss, 1971;Befus, 1977). It has also been reported (Mayer & Pappas, 1976) that infection with H. microstoma leads to an elevated host metabolic rate but only during the first 12 days of infection. It is possible that any increase in metabolic rate may result in an increased body temperature and directly account for the various increased rates of fatty acid synthesis observed in the early phase of infection.…”

Section: Body Temperaturementioning

confidence: 86%

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Fatty acid and cholesterol synthesis in mice infected with the tapewormHymenolepis microstoma

Rath

Walkey

1987

Parasitology

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Infection with Hymenolepis microstoma significantly affected the lipid metabolism of young male Balb/C mice. Infection increased the rates of hepatic fatty acid and cholesterol synthesis and cholesterol synthesis by the gut. Decreases were recorded in testicular fatty acid synthesis and in the weights of testes and white epididymal adipose tissue. Plasma glucose decreased rapidly during infection. The observed changes in lipogenesis could not be attributed to changes in food intake or body temperature. The changes are discussed in relation to nutritional interactions between host and parasite and the possible effects on host hormone levels. The presence of newly synthesized fatty acid in H. microstoma is also reported.

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Section: Body Temperaturesupporting

confidence: 84%

Section: Body Temperaturementioning

confidence: 86%

Fatty acid and cholesterol synthesis in mice infected with the tapewormHymenolepis microstoma

Rath

Walkey

1987

Parasitology

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“…Changes in mouse body mass did not vary among any treatment groups for either experiment, and all mice showed the expected mass increase over time. Therefore, even if increased metabolic rate occurred during coinfection, as has been demonstrated for single infections of H. microstoma [ 57 ] and H. bakeri [ 58 ], mice were able to compensate (e.g., via decreased activity or increased food intake) to maintain body mass. While small intestine length was similar for single and coinfections, our hypothesis that coinfected mice would have greater masses than single-infected mice was supported.…”

Section: Resultsmentioning

confidence: 99%

Order of Inoculation during Heligmosomoides bakeri and Hymenolepis microstoma Coinfection Alters Parasite Life History and Host Responses

et al. 2013

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Parasite life history may differ during coinfection compared to single infections, and the order of infection may be an important predictor of life history traits. We subjected laboratory mice (Mus musculus) to single and coinfections with Heligmosomoides bakeri and Hymenolepis microstoma and measured life history traits of worms and also hepatobiliary and morphological responses by the host. We found that fewer H. bakeri larvae established, and adult worms were shorter and produced fewer eggs during a coinfection where H. microstoma occurred first. H. microstoma grew more and released more eggs after simultaneous inoculation of both parasites compared to a single H. microstoma infection, despite similar worm numbers. Mouse small intestine mass, but not length, varied with coinfection and bile duct mass was largest when H. microstoma was given alone or first. Mouse serum alkaline phosphatase levels were greatest for mice infected with H. microstoma only but did not vary with number of scolices; no change in mouse serum alanine transaminase levels was observed. Overall, the order of coinfection influenced life history traits of both H. bakeri and H. microstoma, but changes in survival, growth, and reproduction with order of inoculation were not consistent between the two parasites.

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“…Cestodes are known to cause various kinds of disturbances in the host's metabolism (Aekert and Case 1938;yon Brand 1966;Gleason 1971;Mayer and Pappas 1976;Pappas 1978). Nadakal and Vijayakumaran Nair (1979) have indicated such an adverse effect and revealed alterations in the carbohydrate components of the various tissues like liver, intestinal mucosa and blood of chickens infected with R. tetragona.…”

Section: Discussionmentioning

confidence: 99%

“…Gastro-intestinal parasites, apart from causing histopathologioal changes in the gut, are also known to pause various types of metabolic d~rangements in host animals (A1 Rabii and Platt 1964;von Brand 1966;Symons 1969;Mayer and Pappas 1976). Loss of appetite, impaired digestion and malabsorption of nutrients also ocour during helminth parasitism of the gut (Mulligan 1972).…”

Section: ~Troduetionmentioning

confidence: 99%

Metabolic disturbances caused byRaillietina tetragona (Cestoda) infection in domestic fowl: Effect of infection on certain aspects of protein metabolism

Nair¹,

Nadakal²

1980

Proc Ani Sci

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The effects of two levels of infection with 20 and 50 eysticercoids of Raillietina tetragona (Cestoda) on certain aspects of protein metabolism of White Leghorn chickens were studied for a period of 8 weeks post-infection. Infection had no effect on the total protein content of liver while that in intestinal tissues was slightly reduced. The free amino acid nitrogen in the blood was not altered during infection. The serum total proteins and the serum albuminglobulin ratio were reduced significantly in infected birds. The hypoproteinemia was mainly due to the hypoalbuminemia. The infected birds gained significantly less weight than the uninfected ones. The lowered ,serum proteins is correlated with the lowered weight gain. Pathological changes were more pronounced in birds infected with 50 cysticercoids and during the period from 4 to 6 weeks post-infection.

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Hymenolepis microstoma: Effect of the mouse bile duct tapeworm on the metabolic rate of CF-1 mice

Cited by 9 publications

References 12 publications

Fatty acid and cholesterol synthesis in mice infected with the tapewormHymenolepis microstoma

Fatty acid and cholesterol synthesis in mice infected with the tapewormHymenolepis microstoma

Order of Inoculation during Heligmosomoides bakeri and Hymenolepis microstoma Coinfection Alters Parasite Life History and Host Responses

Metabolic disturbances caused byRaillietina tetragona (Cestoda) infection in domestic fowl: Effect of infection on certain aspects of protein metabolism

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