Hymenolepis microstoma: Early Histopathologic Changes in Mouse Bile Duct

Sanborn, Carolyn R.; Marquardt, William C.; Duszynski, Donald W.

doi:10.2307/3224385

Cited by 11 publications

(2 citation statements)

References 2 publications

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“…This metacestode undergoes rapid asexual multiplication in the mouse liver and is therefore a useful model for drug studies. Hymenolepis microstoma has largely been ignored as a model parasite for drug evaluation although its pathogenesis is well documented, if poorly understood (Gleason, 1971;Litchford, 1963;Lumsden & Karin, 1970;Pappas, 1976Pappas, , 1978Pappas & Mayer, 1976;Sanborn, Marquardt & Duszynski, 1970). Following infection hepatosplenomegaly and enlargement of both small intestine and bile duct develop due to tissue hyperplasia: fibrosis, resulting from local collagen synthesis, does not apparently contribute to this process (Pappas, 1976).…”

Section: Discussionmentioning

confidence: 99%

Action of cyclosporin A on the tapewormsHymenolepis microstoma, H. diminutaandMesocestoides corti in vivo

1989

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The in vivo activity of two cyclosporins, cyclosporin A (CsA) and a non-immunosuppressive derivative of dihydrocylosporin A (DHCsA-d) against three tapeworms, Hymenolepis microstoma, H. diminuta and Mesocestoides corti, has been assessed. CsA reversibly reduced the dry weight of H. microstoma in the mouse, briefly delayed oviposition and had a statistically significant effect on worm numbers recovered. Oral and subcutaneous treatments of both CsA and DHCsA-d were effective in reducing worm weight; juvenile worms were most susceptible but worms of all ages responded to drug by a dramatic reduction in weight from which they recovered. Multiple courses of CsA were no more active than single courses of treatment but dose response suggested that a threshold level of drug was necessary to evoke activity. By contrast, H. diminuta in the rat was completely unaffected by CsA but no explanation for the differences in drug response by these two closely related helminths is forthcoming. Mesocestoides corti responded reversibly to CsA in the mouse by a reduction in asexual proliferation of both liver and peritoneal cavity tetrathyridia. The data presented argue in favour of a range of anti-parasitic activities by cyclosporins but the details of the various putative modes of action remain to be defined.

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Section: Discussionmentioning

confidence: 99%

Action of cyclosporin A on the tapewormsHymenolepis microstoma, H. diminutaandMesocestoides corti in vivo

1989

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“…Infection with H. microstoma evokes inflammation and hypertrophy of the surrounding tissues, with lymphocytic infiltration occurring within 4 days p.i. (Sanborn, Marquardt & Duszynski, 1970) and immunoglobulins becoming detectable between 8 and 25 days p.i. (Moss, 1971;Befus, 1977).…”

Section: Body Temperaturementioning

confidence: 97%

Fatty acid and cholesterol synthesis in mice infected with the tapewormHymenolepis microstoma

Rath

Walkey

1987

Parasitology

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Infection with Hymenolepis microstoma significantly affected the lipid metabolism of young male Balb/C mice. Infection increased the rates of hepatic fatty acid and cholesterol synthesis and cholesterol synthesis by the gut. Decreases were recorded in testicular fatty acid synthesis and in the weights of testes and white epididymal adipose tissue. Plasma glucose decreased rapidly during infection. The observed changes in lipogenesis could not be attributed to changes in food intake or body temperature. The changes are discussed in relation to nutritional interactions between host and parasite and the possible effects on host hormone levels. The presence of newly synthesized fatty acid in H. microstoma is also reported.

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The uranium industry in the industrially developed capitalist countries and in the developing nations in 1970

Andreev¹

1972

At Energy

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Hymenolepis microstoma: Early Histopathologic Changes in Mouse Bile Duct

Cited by 11 publications

References 2 publications

Action of cyclosporin A on the tapewormsHymenolepis microstoma, H. diminutaandMesocestoides corti in vivo

Action of cyclosporin A on the tapewormsHymenolepis microstoma, H. diminutaandMesocestoides corti in vivo

Fatty acid and cholesterol synthesis in mice infected with the tapewormHymenolepis microstoma

The uranium industry in the industrially developed capitalist countries and in the developing nations in 1970

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