Hymenaea stigonocarpa Mart. ex Hayne: A Brazilian medicinal plant with gastric and duodenal anti-ulcer and antidiarrheal effects in experimental rodent models

Abstract

MHs clearly demonstrate antidiarrheal, gastroprotective and cicatrising effects in experimental gastric and duodenal ulcers, and the diet with fruit pulp displays duodenal healing effects. The observed effects may be associated with the antioxidant effect, which may be due the presence of condensed tannins and flavonoids in the bark and fruit of H. stigonocarpa.

Evaluation of Hepatoprotective Activity with different Fractions of Gardenia gummifera Linn. on Paracetamol Induced Liver Damage in Rats

“…The same method carried out to the GGME fractions BTF, BAF, TLF. After oral administration, the acute toxicity and behavioural parameters were described according to the methods of Souza Brito [11]. The observations were performed at 30, 60, 120, 240 and 360 min after the oral treatments.…”

Antimitotic and antimutagenic action of the Hymenaea stigonocarpa bark on dividing cells

“…Furthermore, Snijman et al (2007) report that, besides the potential to alter the cell membrane permeability due to their astringent action, terpenes, mainly diterpenes, acting together with flavonoids, promote antimutagenic effect on cells treated with mutagenic compounds. However, despite Dimech et al (2013) and Orsi et al (2012) reporting the presence of these two chemicals in the alcoholic extract of the the bark of this plant, their mode of action can not yet be infered since their chemical constituents were not fractionated, measured and classified in a specific way. As initially mentioned, few studies have been conducted on the antimutagenic and cytotoxic potential of some species of the genus Hymenaea, however, unlike jatobá-do-cerrado, there already are isolated chemical compounds from these species that promote these activities.…”

“…Thus, under these study conditions, an antimutagenic effect of the concentrations 0.5; 1.0 and 1.5 mg/mL of jatobá-do-cerrado hydroalcoholic extract, versus paracetamol at 0.008 mg/mL, may be suggested. Dimech et al (2013) and Orsi et al (2012), by means of classic and gas chromatography, found that the hydroalcoholic extract of the the bark of H. stigonocarpa Table 2. Number of undifferentiated cells and those in interphase, number of cells under division, and mitotic index values obtained for the A. cepa root cells of the treatment groups Positive Control, Negative Control and Jatoba Control at concentrations of 0.5; 1.0 and 1.5 mg/mL, and Simultaneous Treatment at concentrations of 0.5; 1.0 and 1.5 mg/mL of Hymenaea stigonocarpa alcoholic extract, evaluated at an exposure time of 48 h. consists of flavonoids, especially the isoprenoids; palmitic acid, oleic acid and linoleic acid and diterpenes.…”

“…The infusion of the the bark or outer surface of the suber of this leguminous plant is widely used in folk medicine in the states of these regions for the reduction of cholesterol levels and blood glucose (Souza and Felfili, 2006), stomach pain, cramps, bronchitis and asthma relief (Orsi et al, 2012), as an anthelmintic in the treatment of depression (Valente et al, 2014) and curing urinary tract infections (Dimech et al, 2013). There are large amounts of diterpene acids, anthraquinones, minerals, tannins, pectin, flavonoids, xyloglucans and oligosaccharides in the phytochemical composition of the suber (Cartaxo et al, 2010).…”

Diversidade de angiospermas e espécies medicinais de uma área de Cerrado

“…Após a identificação das plantas coletadas foi realizada uma revisão bibliográfica referente à utilização medicinal de cada uma das espécies. Nessa revisão foram utilizados dicionários de plantas medicinais como Corrêa (1984), levantamentos florísticos de espécies vegetais úteis do Cerrado como Almeida et al (1998) e de plantas medicinais como Brandão (1991), Vieira & Martins (2000), Rodrigues & Carvalho (2001), Rodrigues & Carvalho (2010) …”