Hylan G-F 20 attenuates posttraumatic osteoarthritis progression: Association with upregulated expression of the circardian gene NPAS2

Liu, Chih Chung; Su, Li; Tsai, Wei Yuan; Sun, Hsiao Lun; Lee, Hoong Chien; Wong, Chih Shung

doi:10.1016/j.lfs.2015.09.007

Cited by 7 publications

(7 citation statements)

References 30 publications

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“…Those patients at high risk of disease progression can be retreated 12 months after the first injection even if they are asymptomatic. This statement is supported by increasing evidence of chondroprotective properties of HA 16,17,[50][51][52][53][54][55] and hence can possibly postpone prosthetic surgery. 56 Of course, the management of risk factors is recommended during the remission period.…”

Section: Discussionmentioning

confidence: 84%

Decision Algorithms for the Retreatment with Viscosupplementation in Patients Suffering from Knee Osteoarthritis: Recommendations from the EUROpean VIScosupplementation COnsensus Group (EUROVISCO)

et al. 2017

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Background Viscosupplementation (VS) is a symptomatic treatment of knee osteoarthritis. Although systematic reviews of its repeat use showed favorable benefit/risk ratio, no study has focused on the indication of retreatment. Methods A task force was created to look at issues regarding retreatment with VS in knee osteoarthritis. An attempt was made to reach consensus on several issues: (1) to define treatment "success" and "failure," (2) to determine when to retreat patients successfully treated by a previous VS, (3) to determine how to retreat patients in whom VS failed, (4) to define what to do in case of adverse reaction following previous VS, and (5) to examine the interests of soluble biomarkers to manage retreatment. After debate and review of literature the working group voted on 88 issues. Two "decision trees" were built based on the results of the votes. Results In case of failure, the authors draw attention to the need of a rigorous clinical and radiological analysis, and consider evidence-based medicine. When VS was previously successful, retreatment can be considered after recurrence or increase in pain. However, in subjects with high risk of disease progression, in young patients, and in professional sportsmen, retreatment could be considered systematically, because of the probability of hyaluronic acid to slow osteoarthritis progression. Evidence on soluble biomarkers was not considered as enough strong to support their use as decision tools for patient retreatment. Conclusion The decision algorithms are intended to facilitate consideration of the therapeutic options, in patients with knee osteoarthritis previously treated with VS.

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Section: Discussionmentioning

confidence: 84%

Decision Algorithms for the Retreatment with Viscosupplementation in Patients Suffering from Knee Osteoarthritis: Recommendations from the EUROpean VIScosupplementation COnsensus Group (EUROVISCO)

et al. 2017

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“…The width joints were measured every week after the surgery. 34 The pain behavior of the rat's joints after the surgery was evaluated by using Incapacitance tester. 35 Briefly, the rats were trained to stand in the box located on the Incapacitance tester to evaluate the bipedal balance.…”

Section: Knee Width and Pain Behavior Measurementmentioning

confidence: 99%

<p>Blue Mussel (<em>Mytilus edulis</em>) Water Extract Ameliorates Inflammatory Responses and Oxidative Stress on Osteoarthritis in Obese Rats</p>

Chang

Sudirman

Yen

et al. 2020

JPR

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Purpose: To investigate the effects of Mytilus edulis water extract (MWE) on an anterior cruciate ligament transection and a partial medial meniscectomy surgery to induced osteoarthritis (OA) with the high-fat diet (HFD)-induced obese rats. Methods: The male Sprague-Dawley rats were fed with HFD for 4 weeks before surgery. The OA rats were orally administered with MWE (108.5, 217.0, and 542.5 mg/kg) for 6 weeks. Results: The administration of MWE affected weight loss, triglycerides content, and total cholesterol level. MWE also enhanced the activity of superoxide dismutase and decreased lipid peroxidation degree. Moreover, MWE reduced proinflammatory cytokines level, alleviated inflammation and swelling of the osteoarthritic knee, and reduced loss of proteoglycan in articular cartilage tissue. Conclusion: MWE suppressed proinflammatory mediators and attenuated the cartilage degradation and pain in osteoarthritis rats under obesity condition. Therefore, MWE has the potential to act as an alternative for osteoarthritis treatment.

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“…Исследования, посвященные внутрисуставному введению ГНК лабораторным животным, за последние 10 лет отражены в табл. 2 [29][30][31][32][33][34][35][36][37].…”

Section: исследования эффективности гиалуроновой кислоты In Vivounclassified

“…Liu и соавт. [37], они отметили, что раннее внутрисуставное введение гилана G-F 20 замедляет прогрессирование посттравматического гонартроза со снижением выраженности синовита.…”

Section: о б з о рunclassified

Injectable Hyaluronic Acid Drugs for the Treatment of Knee Osteoarthritis in the Context of Evidence-Based Medicine

Петухов¹,

Корнилов²,

Куляба³

2018

rsp

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Hylan G-F 20 attenuates posttraumatic osteoarthritis progression: Association with upregulated expression of the circardian gene NPAS2

Cited by 7 publications

References 30 publications

Decision Algorithms for the Retreatment with Viscosupplementation in Patients Suffering from Knee Osteoarthritis: Recommendations from the EUROpean VIScosupplementation COnsensus Group (EUROVISCO)

Decision Algorithms for the Retreatment with Viscosupplementation in Patients Suffering from Knee Osteoarthritis: Recommendations from the EUROpean VIScosupplementation COnsensus Group (EUROVISCO)

<p>Blue Mussel (<em>Mytilus edulis</em>) Water Extract Ameliorates Inflammatory Responses and Oxidative Stress on Osteoarthritis in Obese Rats</p>

Injectable Hyaluronic Acid Drugs for the Treatment of Knee Osteoarthritis in the Context of Evidence-Based Medicine

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