Injectable Hyaluronic Acid Drugs for the Treatment of Knee Osteoarthritis in the Context of Evidence-Based Medicine

Петухов, А И; Корнилов, Н. Н.; Куляба, Т. А.

doi:10.14412/1995-4484-2018-239-248

Cited by 8 publications

(5 citation statements)

References 51 publications

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“…Механизм действия ГнК во многом зависит от молекулярной массы. Так, эффект низко-и среднемолекулярных препаратов ГнК опосредуется их взаимодействием с CD44-рецепторами, стимуляцией выработки эндогенной высокомолекулярной ГнК и, как следствие, -улучшением механических свойств синовиальной жидкости [20]. С увеличением молекулярной массы препаратов ГнК снижается их способность к взаимодействию с CD44-рецепторами, улучшается «скольжение» суставных поверхностей, а также уменьшается концентрация провоспалительных медиаторов и улучшается синтез протеогликанов [21].…”

Section: обоснованиеunclassified

Treatment of patients with knee osteoarthritis with hyaluronate sodium (Revisk) in clinical practice

Shostak

Leineman

Трофимов

et al. 2023

HERALD of North-Western State Medical University named after I.

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BACKGROUND: Osteoarthritis is a disease highly associated with a wide range of comorbidities, which leads to significant limitations of the therapeutic possibilities, in particular, the long-term use of non-steroidal anti-inflammatory drugs. Thus, develop algorithms for effective treatment of osteoarthritis aimed at reducing the need for anti-inflammatory therapy is of great importance. AIM: To evaluate the efficacy and safety of hyaluronic acid for the treatment of osteoarthritis in patients with comorbid pathology. MATERIALS AND METHODS: 30 patients aged 40 to 65 years with IIIII stages of knee osteoarthritis who received treatment with the hyaluronate sodium were examined according to the KellgrenLawrence scale. The course of treatment included standard intra-articular injections of Revisk (sterile sodium hyaluronate gel obtained by microbial fermentation) into the knee joints once a week, in a course of 3 injections. During the study non-steroidal anti-inflammatory drugs therapy was allowed at stable standard dosages. The effectiveness of treatment was assessed by changes in the WOMAC index, the Visual Analog scale pain scores for pain on movement, at rest, goniometry data, 30-meters walking test and stair climb test. RESULTS: A positive effect of treatment on all the parameters has been noted: significant improvement in clinical indicators of pain according to the visual analog scale, functional tests, and the WOMAC index scores. The positive dynamics of the estimated parameters during treatment started from the 7th day of therapy. CONCLUSIONS: The hyaluronate sodium (Revisk) can be used for treating patients with IIIII stages of knee osteoarthritis with moderate dysfunction of joints.

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Section: обоснованиеunclassified

Treatment of patients with knee osteoarthritis with hyaluronate sodium (Revisk) in clinical practice

Shostak

Leineman

Трофимов

et al. 2023

HERALD of North-Western State Medical University named after I.

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“…Застосування препаратів гіалуронової кислоти за безпечує відстрочку потреби в ендопротезуванні су глоба [29,30], вони надають аналгетичний ефект, по дібний з таким у нестероїдних протизапальних засобів (НПЗП) [31]; все це робить дану групу препаратів уні кальною. На думку авторитетних експертів, найбіль ший ефект препаратів ГК відзначається при призначен ні їх в ранній стадії ОА, але він присутній і в пізній стадії захворювання, коли неможливо провести хірургічне втручання [32].…”

Section: ключові слова: остеоартроз великих суглобів лікування препарати гіалуронової кислоти ефективністьunclassified

The use of hyaluronic acid preparations for the treatment of osteoarthritis of the major joints

Kalashnikov

Sulyma

Osadchuk

et al. 2021

prmd

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The authors of the article analyzed the experience of domestic and foreign experts in the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major joints. Background and Objective. To analyze the literature sources in order to determine the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major ligaments. Materials and methods. Articles in specialized scientific journals and collections, Internet resource.Results. The analysis of literature sources determined the important role of HA preparations in the supplying and functioning of the articular cartilage. Researchers are inclined to believe that the ideal HA preparation should be as close as possible to the physiological HA of the synovial fluid of the joint. The developed domestic drug Artro-Patch fully corresponds to these parameters. Conclusions. The use of modern injectable HA preparations is advisable at stages 1–3 of OA. Anti-inflammatory effect of HA preparations makes it possible to reduce the dose and time of administration of non-steroidal anti-inflammatory drugs and, as a consequence, reduce the risk of developing many adverse side effects of NSAIDs. The high level of safety of HA preparations, the absence of serious side effects during their long-term use determine their widespread use in the clinical practice of modern orthopedists.

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“…ВМ ГлК улучшает скольжение суставных поверхностей, снижая трение между ними. ГлК также способствует снижению концентрации провоспалительных медиаторов и стимулирует синтез протеогликанов [10][11][12][13][14][15][16] А Б Рис. 11.…”

Section: Introductionunclassified

Comparing the efficacy of hyaluronic acid products with various molecular weights as mono and combined with chondroitin sulfate regimens in treatment of patients with stage I–III knee osteoarthritis

Макаров¹,

Bialik²,

Макаров³

et al. 2020

Naučno-praktičeskaâ revmatologiâ

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Aim: to evaluate the effectiveness of hyaluronic acid (HA) preparations with different molecular weights and in combination with chondroitin sulfate (HS) for intra-articular (IA) injections in the treatment of patients with stage I–III knee OA.Subjects and methods. IA HA injections were performed 160 patients with primary and post-traumatic knee OA of the I–III stages at the department of traumatology-orthopedics, V.A. Nasonova Research Institute of Rheumatology for the period from September 2017 to June 2019. Patients were divided into 4 groups. Group 1 consisted of 80 patients treated with low molecular weight (LMW) HA, group 2–20 patients treated with medium molecular weight (MMW) HA, group 3–30 patients treated with high molecular weight (HMW) HA, and group 4–30 patients who were intraarticular introduced HA with HS. The course of IA injections was 2 for LMW, HMW, and HA with HS, and 3 for MMW HA. Injections were performed with an interval of 1 week. To evaluate the results of treatment, we studied the intensity of pain according to VAS and the total score of KOOS before treatment and on follow-up examinations 1, 3 and 6 months after the course of IA HA injections.Results. The maximum reduction in pain with IA HA injections at stage I of knee OA occurred by 3 months after the course of treatment. Moreover, improvement was detected by 1 month in 84.3% of cases, and remained until the end of the study in 71.1% of patients. All HA preparations used in stage I of knee OA were effective. At stage II of the knee OA after 3 months after the course of IA HA, different efficiencies of HA preparations were revealed. So, in the groups of LMW, MMW and HA with HS, the improvement persisted up to 3 months, and in the group of HMW HA – up to 1 month. After 3 months, the best results were shown by HA with HS, by 6 months the results were comparable. IA HA injections at the II stage of knee OA led to good and excellent results 1 month after the course of treatment in 53.9% of cases, but by the end of the study, improvement remained in only 30.8% of patients. In the case of the use of HA in stage III of the knee OA, the effectiveness of the studied drugs was comparable, and the maximum improvement was achieved by 1 month. The positive effect of IA HA injections in patients with stage III of the knee OA one month after the course of treatment was obtained in 40.6% of cases, by 3 months it decreased to 18.8%, and by 6 months – to 15.7% of patients.Conclusions. IA injections of HA at stage I of the knee OA is a highly effective method of conservative treatment, which allows to relieve pain and improve the condition of the knee joint for a period of 6 months or more. The use of HA preparations at stage II of the knee OA allows reducing pain up to 3 months with IA injections of LMW and MMW HA, as well as HA with HS. HMW HA helps reduce pain intensity for a period of 1 month. The use of HA preparations in stage III of the knee OA leads to a short-term relief of symptoms of OA.

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Injectable Hyaluronic Acid Drugs for the Treatment of Knee Osteoarthritis in the Context of Evidence-Based Medicine

Cited by 8 publications

References 51 publications

Treatment of patients with knee osteoarthritis with hyaluronate sodium (Revisk) in clinical practice

Treatment of patients with knee osteoarthritis with hyaluronate sodium (Revisk) in clinical practice

The use of hyaluronic acid preparations for the treatment of osteoarthritis of the major joints

Comparing the efficacy of hyaluronic acid products with various molecular weights as mono and combined with chondroitin sulfate regimens in treatment of patients with stage I–III knee osteoarthritis

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