Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans

Tomé‐Carneiro, João; Crespo, M. Carmen; Iglesias‐Gutiérrez, Eduardo; Martín, Roberto; Gil-Zamorano, Judit; Tomás‐Zapico, Cristina; Burgos‐Ramos, Emma; Correa, Carlos; Gómez-Coronado, Diego; Lasunción, Miguel A.; Herrera, Emílio; Visioli, Francesco; Dávalos, Alberto

doi:10.1016/j.jnutbio.2016.05.009

Cited by 42 publications

(46 citation statements)

References 51 publications

(64 reference statements)

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“…A total of 19 miRNAs were analyzed using the above‐mentioned target genes. The interaction network between the gene targets and modulated miRNAs was performed as previously described, using the above‐mentioned target genes targeted by at least two miRNAs. Target dot sizes were directly correlated with the number of interactions with the miRNA's set.…”

Section: Methodsmentioning

confidence: 65%

“…An important feature of miRNAs is that one gene can be regulated by different miRNAs. To search for possible validated target genes potentially modulated by more than one miRNA and which responded to the dietary intervention in HD‐patients, GI analysis was performed ( Figure ) . Putative GIs (number of dietary HD‐modulated miRNAs that can potentially target the 3′UTR of the protein coding gene showed) were obtained using validated target genes from databases (see Experimental Section).…”

Section: Resultsmentioning

confidence: 99%

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Customized Dietary Intervention Avoids Unintentional Weight Loss and Modulates Circulating miRNAs Footprint in Huntington's Disease

Aganzo

Montojo

Hazas

et al. 2018

Molecular Nutrition Food Res

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Scope Huntington's disease (HD) is a rare progressive neurodegenerative disorder of genetic origin, with no definitive treatment. Unintentional weight loss (UWL) is a clinical feature of symptomatic HD subjects. To prevent UWL, a customized HD diet is designed and its impact on plasma miRNA HD footprint and neurological parameters is examined. Methods and results Eleven participants are included, BMI ≤ 18 kg m–2 or UWL of 5% in 6 months or 10% in a year. Diet design is based on nutritional surveys and interviews of participants and caregivers and on published literature review. Twelve‐month dietary intervention, with follow‐up every 3 months, induces high diet adherence, which manages to curb UWL in all participants (73% gained weight). Noticeable increases in fat mass and leptin levels are obtained. The results also show significant decrease in the expression of 19 miRNAs, which are previously reported to be upregulated in HD‐patients versus healthy controls: revealing hsa‐miR‐338‐3p, hsa‐miR‐128‐3p, hsa‐miR‐23a‐3p, and hsa‐miR‐24‐3p as potential HD‐biomarkers. The diminished expression of hsa‐miR‐100‐5p reflects the general maintenance of the functional status. Cognitive status is improved in six of 11 participants, while only three present better motor‐score values. Conclusion A customized HD‐diet prevents UWL and modified miRNAs HD‐footprint. The normalization of miRNA values suggests its potentially use as HD‐biomarkers.

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Section: Methodsmentioning

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Customized Dietary Intervention Avoids Unintentional Weight Loss and Modulates Circulating miRNAs Footprint in Huntington's Disease

Aganzo

Montojo

Hazas

et al. 2018

Molecular Nutrition Food Res

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“…There is some in vitro evidence that olive (poly)phenols alter microRNAs in cancer cells. Tomé‐Carneiro et al also reported modulation of microRNAs, namely, miR‐193a‐5p in rodents and humans after the administration of nutritionally relevant amounts of HT (Tome‐Carneiro et al, ), whereas miR‐802‐5p was found to be consistently modulated in mouse liver and intestine after dietary supplementation (Lopez de las Hazas et al, ). These observations could in part explain (at the molecular level) some of the biological effects of HT.…”

Section: Pharmacological and Nutraceutical Properties Of Htmentioning

confidence: 96%

“…These observations could in part explain (at the molecular level) some of the biological effects of HT. Yet, although microRNAs are increasingly being indicated as potentially relevant targets for drugs and/or food components (Tome‐Carneiro et al, ), we would like to reiterate the need for further ad hoc research.…”

Section: Pharmacological and Nutraceutical Properties Of Htmentioning

confidence: 99%

“…Nevertheless, both dyslipidemia and hepatic fat accumulation were reported in rodents after EVOO consumption (Arbones‐Mainar et al, ). In one example, an 8‐week supplementation with a dietary attainable amount of HT resulted in hypertriglyceridemia in mice (Tome‐Carneiro et al, ). Moreover, after a 10‐week vitamin E‐deficient diet, a 2‐week supplementation with 100‐mg HT·kg −1 diet led to a rise in plasma TAG in rats (Rowett Hooded Lister strain; Rodriguez‐Gutierrez et al, ).…”

Section: Pharmacological and Nutraceutical Properties Of Htmentioning

confidence: 99%

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An overview of the pharmacology of olive oil and its active ingredients

Visioli

Dávalos

Hazas

et al. 2019

British J Pharmacology

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In addition to providing sensory stimuli, usually taste, smell and sight, olive oil contains a range of minor components, mostly phenolic in nature. These components are endowed with pharmacological or pharma‐nutritional properties that are the subject of active research worldwide. Based on our more than 25 years of experience in this field, we critically focus on what we believe are the most pharmacologically prominent actions of the constituents of olive oil. Most of the effects are due to the phenolic compounds in extra virgin olive oil, such as hydroxytyrosol and oleocanthal (which are often mis‐categorized as in vivo antioxidants) and concern the cardiovascular system. Other potentially beneficial activities are still to be investigated in depth. We conclude that—in the context of a proper diet that includes high‐quality products—the use of high‐quality olive oil contributes to achieving and sustaining overall health. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Hydroxytyrosol Induces Dyslipidemia in an ApoB100 Humanized Mouse Model

López de las Hazas,

del Saz‐Lara,

Cedó

et al. 2023

Molecular Nutrition Food Res

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ScopeExtra virgin olive oil has numerous cardiopreventive effects, largely due to its high content of (poly)phenols such as hydroxytyrosol (HT). However, some animal studies suggest that its excessive consumption may alter systemic lipoprotein metabolism. Because human lipoprotein metabolism differs from that of rodents, this study examines the effects of HT in a humanized mouse model that approximates human lipoprotein metabolism.Methods and resultsMice are treated as follows: control diet or diet enriched with HT. Serum lipids and lipoproteins are determined after 4 and 8 weeks. We also analyzed the regulation of various genes and miRNA by HT, using microarrays and bioinformatic analysis.An increase in body weight is found after supplementation with HT, although food intake was similar in both groups. In addition, HT induced the accumulation of triacylglycerols but not cholesterol in different tissues. Systemic dyslipidemia after HT supplementation and impaired glucose metabolism are observed. Finally, HT modulates the expression of genes related to lipid metabolism, such as Pltp or Lpl.ConclusionHT supplementation induces systemic dyslipidemia and impaired glucose metabolism in humanized mice. Although the numerous health‐promoting effects of HT far outweigh these potential adverse effects, further carefully conducted studies are needed.

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Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans

Cited by 42 publications

References 51 publications

Customized Dietary Intervention Avoids Unintentional Weight Loss and Modulates Circulating miRNAs Footprint in Huntington's Disease

Customized Dietary Intervention Avoids Unintentional Weight Loss and Modulates Circulating miRNAs Footprint in Huntington's Disease

An overview of the pharmacology of olive oil and its active ingredients

Hydroxytyrosol Induces Dyslipidemia in an ApoB100 Humanized Mouse Model

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