2018
DOI: 10.1002/mnfr.201800619
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Scope Huntington's disease (HD) is a rare progressive neurodegenerative disorder of genetic origin, with no definitive treatment. Unintentional weight loss (UWL) is a clinical feature of symptomatic HD subjects. To prevent UWL, a customized HD diet is designed and its impact on plasma miRNA HD footprint and neurological parameters is examined. Methods and results Eleven participants are included, BMI ≤ 18 kg m–2 or UWL of 5% in 6 months or 10% in a year. Diet design is based on nutritional surveys and intervie… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
12
0

Year Published

2019
2019
2022
2022

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 16 publications
(12 citation statements)
references
References 50 publications
(78 reference statements)
0
12
0
Order By: Relevance
“…Recently, the modulation of circulating miRNAs (c-miRNAs) through dietary compounds [16] and diets [17,18] has been described. Some studies affirm that environmental factors, such as diet and exercise, influence the epigenetic mechanisms that affect the response to postprandial lipemia [19], but epigenetic factors, such as c-miRNAs, are poorly characterized [20].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, the modulation of circulating miRNAs (c-miRNAs) through dietary compounds [16] and diets [17,18] has been described. Some studies affirm that environmental factors, such as diet and exercise, influence the epigenetic mechanisms that affect the response to postprandial lipemia [19], but epigenetic factors, such as c-miRNAs, are poorly characterized [20].…”
Section: Introductionmentioning
confidence: 99%
“…The small RNAs have been identified as highly stable in the biofluids ( 31 ), being potential “reporters” of pathogenic loop occurring in the CNS and representing also potential therapeutic targets to break off detrimental molecular cascades triggered by mHTT. Our study adds to other works ( 20 , 26 28 ) on the potential utility of circulating microRNAs, as mirrors of the pathogenic processes that take place in the CNS ( 18 , 20 ), as well as biomarkers showing quantifiable changes after symptomatic approaches ( 28 ). Moreover, circulating micro-RNAs may offer potential advantages in terms of disease specificity compared to other approach, such as circulating NFL, which was already shown to be a promising peripheral biomarker for many neurological diseases, including HD ( 32 , 33 ).…”
Section: Discussionmentioning
confidence: 54%
“…Several studies on microRNA pathogenic role in HD have been published in the last two decades, especially in postmortem analyses: besides the dysregulation of single micro-RNA, such as miR-9/9 * , miR-132, miR-4488, miR-196a-5p, and miR-549a, among others ( 17 22 ), the alteration of the miRNome in HD CNS seems to be global because the mHTT affects the action of argonaute-2, potentially interfering with the biogenesis of all micro-RNA ( 23 ). Micro-RNA levels have also been measured in biofluids from HD patients, such as CSF ( 24 ), PBMC ( 25 ), and plasma ( 20 , 26 28 ). Previous results on circulating microRNAs are still preliminary, rather inconsistent, and have been obtained on small populations.…”
Section: Introductionmentioning
confidence: 99%
“…miRNAs are small non-coding RNAs and are upregulated in HD. 67 It is believed to demonstrate a potential impairment in the cholesterol metabolism pathway in HD. Other studies have also demonstrated that certain dietary factors, like a diet high in dairy product, could speed up the rate of phenoconversion, leading to an earlier age of onset.…”
Section: Resultsmentioning
confidence: 99%