Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression

Yang, Xiaofeng; Jing, Ting; Li, Y.; He, Yongqing; Zhang, W.; Wang, B.; Yuan, Xiao; Wang, W.; Zhang, J.; Wei, Jiangtao; Lin, Rong

doi:10.2174/1566524017666170421151940

Cited by 32 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with the previous report, we observed that Res up‐regulated the expression of SIRT1, whereas LPS moderately reduced the expression of SIRT1 in BMDMs. The results were consistent with previously reports, in which there was lower SIRT1 expression in the inflammatory lungs of animal models with LPS‐induced ALI and pulmonary contusion . However, our further study indicated that co‐treatment of BMDMs with both Res and LPS prevented the LPS‐induced suppression of SIRT1 (Figure C), demonstrating the important role of Res in activation of SIRT1 signalling.…”

Section: Discussionsupporting

confidence: 93%

“…The results were consistent with previously reports, in which there was lower SIRT1 expression in the inflammatory lungs of animal models with LPS-induced ALI and pulmonary contusion. [26][27][28] However, our further study indicated that co-treatment of BMDMs with both Res and LPS prevented the LPS-induced suppression of SIRT1 ( Figure 7C) In conclusion, this study indicated that Res suppressed lung inflammation of mice with LPS-induced ALI, in association with significantly reduced neutrophil infiltration and production of F I G U R E 8 Schematic diagram of resveratrol (Res)-mediated suppression of ALI through STAT3/SOCS3 signalling. LPS induces oxidative stress and activates STAT3, subsequently induces IL-6, IL-1beta and CXCL15 expression, ultimately causes ALI/ARDS.…”

Section: Res Suppressed M1 Cell-biased Polarization Of Bmdms From Wmentioning

confidence: 64%

See 1 more Smart Citation

Resveratrol decreases CD45⁺CD206⁻ subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway

Chen

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are life‐threatening condition in critically ill patients. Resveratrol (Res), a natural polyphenol, has therapeutic effect in animal model with ALI; however, whether Res attenuates ALI through modulation of macrophage phenotypes in the animal model remains unknown. We in this study treated LPS‐induced murine ALI with 30 mg/kg Res and observed significantly reduced severity of ALI in the Res‐treated mice 48 hours after Res treatment. Neutrophil infiltrates were significantly reduced, accompanied with lower infiltration of CD45+Siglec F− phenotype macrophages, but higher population of CD45+Siglec F+ and CD45+CD206+ alternatively activated macrophages (M2 cells) in the Res‐treated mice with ALI. In addition, the expression of IL‐1beta and CXCL15 cytokines was suppressed in the treated mice. However, Res treatment in mice with myeloid cell‐restricted SOCS3 deficiency did not significantly attenuate ALI severity and failed to increase population of both CD45+Siglec F+ and CD45+CD206+ M2 subtype macrophages in the murine ALI. Further studies in wild‐type macrophages revealed that Res treatment effectively reduced the expression of IL‐6 and CXCL15, and increased the expression of arginase‐1, SIRT1 and SOCS3. However, macrophages’ lack of SOCS3 expression were resistant to the Res‐induced suppression of IL‐6 and CXCL15 in vitro. Thus, we conclude that Res suppressed CD45+Siglec F− and CD45+CD206− M1 subtype macrophages through SOCS3 signalling in the LPS‐induced murine ALI.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Res Suppressed M1 Cell-biased Polarization Of Bmdms From Wmentioning

confidence: 64%

Resveratrol decreases CD45⁺CD206⁻ subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway

Chen

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Sirt1 has been shown to be essential for synaptic plasticity, cognitive functions [150], modulation of learning, and the preservation of memory processes that deteriorate during aging, in the brain [151]. Recently, in vitro and in vivo studies suggest that HT and OLE inhibit the inflammatory response through different pathways regulated by several members of the sirtuin family (e.g., Sirt1, Sirt2, Sirt6) [140,[152][153][154][155][156].…”

Section: Redox Homeostasis and The Inflammatory Responsementioning

confidence: 99%

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Leri

Scuto

Ontario

et al. 2020

IJMS

311

213

View full text Add to dashboard Cite

The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed at reducing the prevalence of these conditions in the population are limited to a safer lifestyle including physical/mental exercise, a reduced caloric intake, and a proper diet in a convivial environment. The claimed health benefits of the Mediterranean and Asian diets have been confirmed in many clinical trials and epidemiological surveys. These diets are characterized by several features, including low meat consumption, the intake of oils instead of fats as lipid sources, moderate amounts of red wine, and significant amounts of fresh fruit and vegetables. In particular, the latter have attracted popular and scientific attention for their content, though in reduced amounts, of a number of molecules increasingly investigated for their healthy properties. Among the latter, plant polyphenols have raised remarkable interest in the scientific community; in fact, several clinical trials have confirmed that many health benefits of the Mediterranean/Asian diets can be traced back to the presence of significant amounts of these molecules, even though, in some cases, contradictory results have been reported, which highlights the need for further investigation. In light of the results of these trials, recent research has sought to provide information on the biochemical, molecular, epigenetic, and cell biology modifications by plant polyphenols in cell, organismal, animal, and human models of cancer, metabolic, and neurodegenerative pathologies, notably Alzheimer’s and Parkinson disease. The findings reported in the last decade are starting to help to decipher the complex relations between plant polyphenols and cell homeostatic systems including metabolic and redox equilibrium, proteostasis, and the inflammatory response, establishing an increasingly solid molecular basis for the healthy effects of these molecules. Taken together, the data currently available, though still incomplete, are providing a rationale for the possible use of natural polyphenols, or their molecular scaffolds, as nutraceuticals to contrast aging and to combat many associated pathologies.

show abstract

“…In the DHM only and DHM + LPS groups, the mice received DHM (500 mg/kg) by gavage once per day for 4 consecutive days prior to the intranasally administration 25 μg of LPS. Twenty‐four hours after LPS administration, the plasma, tissue samples, and bronchoalveolar lavage fluid (BALF) of mice were collected for the experiments as described previously . Before formal experiments, a preexperiment was carried out and we found that DHM at the dose of 500 mg/kg exerts strong protective effects against the lung injury (Supplemental Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Lungs from mice in all groups were removed, embedded, and cut into 7 μm sections. Subsequently, tissue sections were stained with H&E. Semi‐quantitative analyses of inflammatory cell infiltration in lung sections were performed as previously described …”

Section: Methodsmentioning

confidence: 99%

Protective effect of dihydromyricetin on LPS-induced acute lung injury

Wang

Xiao

Yang

et al. 2018

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Dihydromyricetin (DHM), a bioactive flavonoid component isolated from Ampelopsis grossedentata, is known to have anti-inflammatory effect, but the effect of DHM on acute lung injury (ALI) is largely unknown. Here, we investigated the effect of DHM on ALI and the underlying mechanism by bioinformatic analyses and animal experiments. We found that pretreatment with DHM ameliorated lung pathological changes and suppressed the inflammation response in lung tissues after LPS challenge. The potential targets of DHM were predicted by DDI-CPI and DRAR-CPI tools and analyzed using the STRING server to predict the functionally related signaling pathways, such as MAPK signaling. Molecular docking calculations indicated that DHM could be embedded tightly into the binding pocket of ERK, JNK, and p38. Furthermore, the activation of MAPK signaling induced by LPS was inhibited by DHM. In conclusion, these findings suggest that DHM may exert its protective effect on ALI by inhibiting MAPK signaling. The present study supports a potential clinical application for DHM in treating ALI and provides a novel design that combines in silico methods with in vivo experiments for drug research.

show abstract

Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression

Cited by 32 publications

References 0 publications

Resveratrol decreases CD45⁺CD206⁻ subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway

Resveratrol decreases CD45⁺CD206⁻ subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Protective effect of dihydromyricetin on LPS-induced acute lung injury

Contact Info

Product

Resources

About

Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression

Cited by 32 publications

References 0 publications

Resveratrol decreases CD45+CD206− subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway

Resveratrol decreases CD45+CD206− subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Protective effect of dihydromyricetin on LPS-induced acute lung injury

Contact Info

Product

Resources

About

Resveratrol decreases CD45⁺CD206⁻ subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway

Resveratrol decreases CD45⁺CD206⁻ subtype macrophages in LPS‐induced murine acute lung injury by SOCS3 signalling pathway