Hydroxysafflor yellows alleviate thrombosis and acetaminophen-induced toxicity in vivo by enhancing blood circulation and poison excretion

Wang, Liwei; Cui, Xue-Ying; He, Jiang-Feng; Duan, Shen; Liu, Chunrui; Shan, Cheng-Bin; Wang, Yu; Ma, Cui

doi:10.1016/j.phymed.2021.153579

Cited by 9 publications

(2 citation statements)

References 32 publications

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“…Batch processing is an additional feature of this tool to analyze multiple videos at once, which may reduce the effort of selecting data one by one manually. The following section presents the potential Pros and Cons of our newly established OpenBloodFlow GUI package [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

OpenBloodFlow: A User-Friendly OpenCV-Based Software Package for Blood Flow Velocity and Blood Cell Count Measurement for Fish Embryos

Farhan

Saputra

Suryanto

et al. 2022

Biology

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The transparent appearance of fish embryos provides an excellent assessment feature for observing cardiovascular function in vivo. Previously, methods to conduct vascular function assessment were based on measuring blood-flow velocity using third-party software. In this study, we reported a simple software, free of costs and skills, called OpenBloodFlow, which can measure blood flow velocity and count blood cells in fish embryos for the first time. First, videos captured by high-speed CCD were processed for better image stabilization and contrast. Next, the optical flow of moving objects was extracted from the non-moving background in a frame-by-frame manner. Finally, blood flow velocity was calculated by the Gunner Farneback algorithm in Python. Data validation with zebrafish and medaka embryos in OpenBloodFlow was consistent with our previously published ImageJ-based method. We demonstrated consistent blood flow alterations by either OpenBloodFlow or ImageJ in the dorsal aorta of zebrafish embryos when exposed to either phenylhydrazine or ractopamine. In addition, we validated that OpenBloodFlow was able to conduct precise blood cell counting. In this study, we provide an easy and fully automatic programming for blood flow velocity calculation and blood cell counting that is useful for toxicology and pharmacology studies in fish.

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Section: Discussionmentioning

confidence: 99%

OpenBloodFlow: A User-Friendly OpenCV-Based Software Package for Blood Flow Velocity and Blood Cell Count Measurement for Fish Embryos

Farhan

Saputra

Suryanto

et al. 2022

Biology

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“…The inhibition of platelet aggregation is mainly manifested by the following aspects: ADP receptor transduction and expression of PAC-1 glycoprotein on platelet membranes, calcium ion activation, and regulation of the levels of cyclic adenosine monophosphate, arachidonic acid, and thromboxane (TX) A 2 in intracellular platelets by ADP [ 47 ]. Wang et al [ 48 ] established a phenylhydrazine-induced thrombosis model and verified that HSYA could significantly inhibit thrombosis in vivo and protect the body from exogenous or disease-induced endogenous toxins by promoting blood circulation and accelerating toxin excretion. Studies have investigated the effects of intravenous HSYA injections on the rate of dissolution of blood clots, blood fibrinogen (FIB) levels, prothrombin time (PT), blood coagulation time in experimental animals, and thrombus formation in vivo and in vitro.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Pharmacological Activities of Safflower Yellow and Its Clinical Applications

Yan

Wen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Safflower is an annual herb used in traditional Chinese herbal medicine. It consists of the dried flowers of the Compositae plant safflower. It is found in the central inland areas of Asia and is widely cultivated throughout the country. Its resistance to cold weather and droughts and its tolerance and adaptability to salts and alkalis are strong. Safflower has the effect of activating blood circulation, dispersing blood stasis, and relieving pain. A natural pigment named safflower yellow (SY) can be extracted from safflower petals. Chemically, SY is a water-soluble flavonoid and the main active ingredient of safflower. The main chemical constituents, pharmacological properties, and clinical applications of SY are reviewed in this paper, thereby providing a reference for the use of safflower in preventing and treating human diseases. Methods. The literature published in recent years was reviewed, and the main chemical components of SY were identified based on chemical formula and structure. The pharmacological properties of hydroxysafflor yellow A (HSYA), SYA, SYB, and anhydrosafflor yellow B (AHSYB) were reviewed. Results. The main chemical constituents of SY included HSYA, SYA, SYB, and AHSYB. These ingredients have a wide range of pharmacological activities. SY has protective effects on the heart, kidneys, liver, nerves, lungs, and brain. Moreover, its effects include, but are not limited to, improving cardiovascular and cerebrovascular diseases, abirritation, regulating lipids, and treating cancer and diabetic complications. HSYA is widely recognised as an effective ingredient to treat cardiovascular and cerebrovascular diseases. Conclusion. SY has a wide range of pharmacological activities, among which improving cardiovascular and cerebrovascular diseases are the most significant.

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