Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis

Ye, Jingxue; Wang, Ruiying; Wang, Min; Fu, Jianhua; Zhang, Qiong; Sun, Guibo; Sun, Xiaobo

doi:10.1155/2021/6643615

Cited by 27 publications

(14 citation statements)

References 49 publications

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“…The main components of XFZYD exhibited profound cardioprotective effects [ 10 ]. For example, hydroxysafflor yellow A reduced MI/RI injury, suppressed calcium overload in cardiomyocytes, and prevented the induction of their apoptosis [ 42 ]. Moreover, chlorogenic acid inhibited activation of the NF- κ B and JNK pathways in cardiomyocytes [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

The Improvement of Cardiac and Endothelial Functions of Xue-Fu-Zhu-Yu Decoction for Patients with Acute Coronary Syndrome: A Meta-Analysis of Randomized Controlled Trials

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Xue-Fu-Zhu-Yu decoction (XFZYD) is a traditional Chinese prescription that has been used to treat patients with blood stasis in China for many years. The present study aimed to evaluate the improvement of cardiac and endothelial functions of XFZYD for patients with acute coronary syndrome (ACS) through a systematic review and meta-analysis. Methods. Six databases were searched to collect RCTs related to the treatment of XFZYD for ACS. The primary outcomes were cardiac and endothelial functions, including the levels of left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), and left ventricular end-systolic diameter (LVESD) in echocardiography, as well as the changes in the levels of nitric oxide (NO), endothelin-1 (ET-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in the serum. The secondary outcomes were the blood levels of oxidative damage markers (including superoxide dismutase (SOD) and malondialdehyde (MDA)), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatine kinase-MB (CK-MB), and cardiac troponin I (cTnI) as well as the incidence of adverse drug reactions (ADRs). Weighted mean difference (WMD) was estimated for all the outcomes with the random effects model. This type of analysis was conducted in the subgroups of the ACS subtypes, and the methodological quality was assessed using the handbook of Cochrane Collaboration. Results. A total of 1,658 records were identified, and 16 randomized controlled trials (1,171 patients) were included. The primary outcomes suggested that XFZYD combined with routine treatment improved LVEF, reduced LVEDD and LVESD, and also improved the serum levels of NO, and reduced the levels of ET-1 and ICAM-1. XFZYD combination therapy significantly ameliorated the blood levels of SOD, MDA, BNP, CK-MB, and cTnI. However, the results indicated no significant difference between XFZYD plus routine treatment and routine treatment for the levels of VCAM-1 and CRP. Moreover, all the ADRs reported in the included studies were slight and the patients recovered soon. Conclusions. The present study suggested that XFZYD may improve the cardiac and endothelial functions of ACS patients without serious ADRs. However, based on the mediocre methodological quality, the aforementioned conclusion should be confirmed in a multicenter, large-scale, and accurately designed clinical trial.

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Section: Discussionmentioning

confidence: 99%

The Improvement of Cardiac and Endothelial Functions of Xue-Fu-Zhu-Yu Decoction for Patients with Acute Coronary Syndrome: A Meta-Analysis of Randomized Controlled Trials

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Hydroxysafflor yellow A, one of the main active ingredients of Carthamus tinctorius L . , alleviates MI/RI damage to both heart structures and functions ( Ye et al, 2021 ). In addition, safranal, an active ingredient extracted from saffron, exerts a protective effect on the cardiovascular system.…”

Section: Potential Action Mechanisms Of Tcm For Cmvdmentioning

confidence: 99%

Traditional chinese medicine in coronary microvascular disease

et al. 2022

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Coronary microvascular disease (CMVD) is common in patients with cardiovascular risk factors and is associated with an increased risk of adverse cardiovascular events. Although the study of CMVD in modern medicine is ongoing, there is still no effective treatment for it. Traditional Chinese medicine (TCM) has some clinical advantages based on syndrome differentiation and individualized treatment. In this review, we review the clinical significance, pathogenesis, and current treatments of CMVD and systematically summarize the clinical efficacy and potential action mechanisms of TCM for CMVD. In addition, the scientific problems that need to be solved urgently and the research strategy of TCM for CMVD are described. CMVD has great clinical significance, but there are still many gaps in the related research. This review aims to attract the attention of clinicians to CMVD and promote research on CMVD in TCM.

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“…Tetrahydrocurcumin [166], higenamine [167], and ginsenoside Rb1 [168] all attenuates apoptosis and MIRI through PI3K/AKT/mTOR signaling. Hydroxysafflor yellow A inhibited calcium overload and apoptosis in cardiomyocytes by targeting the L-type calcium channel (LTCC) [169]. Baicalein inhibited apoptosis through KLF4-MARCH5-Drp1 signaling to inhibit cardiomyocyte-induced mitochondrial apoptosis [170].…”

Section: Apoptosismentioning

confidence: 99%

Mechanisms of action of natural small-molecule drugs in cardiovascular disease

SUN

Luo

et al. 2022

Preprint

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Cardiovascular diseases (CVDs) cause massive morbidity and mortality. In recent years, natural small-molecule therapeutics have attracted much attention for their significant efficacy. Articles have been published to study the intervention of natural drugs (including monomers, compounds, compound and neo-combinations) on one type of cardiovascular disease, but the number and variety of natural drugs included are small and insufficient, and there are no articles detailing the protective effects of different types of natural small molecule drugs on multiple cardiovascular diseases. Natural small molecule drugs have high biological activity and structural diversity, and are more likely to enter the body to exert their effects. In this article, we describe the efficacy of such drugs for anti-atherosclerosis, cardiomyocyte repair, and antagonism of ventricular remodeling, heart failure, and arrhythmias to provide an experimental basis for clinical research and identification of new therapeutic approaches.

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Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis

Cited by 27 publications

References 49 publications

The Improvement of Cardiac and Endothelial Functions of Xue-Fu-Zhu-Yu Decoction for Patients with Acute Coronary Syndrome: A Meta-Analysis of Randomized Controlled Trials

The Improvement of Cardiac and Endothelial Functions of Xue-Fu-Zhu-Yu Decoction for Patients with Acute Coronary Syndrome: A Meta-Analysis of Randomized Controlled Trials

Traditional chinese medicine in coronary microvascular disease

Mechanisms of action of natural small-molecule drugs in cardiovascular disease

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