Hydroxysafflor yellow A actives BKCa channels and inhibits L-type Ca channels to induce vascular relaxation

Wang, Na; He, Dongmei; Zhou, Yuanqun; Wen, Jing; Liu, Xiaoqin; Li, Pengyun; Yang, Yan; Cheng, Jun

doi:10.1016/j.ejphar.2019.172873

Cited by 11 publications

(7 citation statements)

References 38 publications

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“…Safflowers are well-known herbs used to improve circulation, eliminate blood stasis, and treat cardiovascular and thrombotic diseases. [ 81 , 82 ] Hydroxy saffron yellow A is the most significant bioactive component of saffron. [ 83 ] Pathogenesis of DR is strongly linked to diseases such as vascular lesions, neuropathy, and inflammation, in which Nuclear Factor erythroid 2-Related Factor 2 (Nrf2)/heme oxygenase 1 (HO-1) signaling pathway-mediated inflammation and oxidative stress plays a key role.…”

Section: Resultsmentioning

confidence: 99%

Exploring the protective effects of herbal monomers against diabetic retinopathy based on the regulation of autophagy and apoptosis: A review

Hu,

Wang,

et al. 2023

Medicine

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Diabetic retinopathy (DR) has become one of the top 3 blinding eye diseases in the world. In spite of recent therapeutic breakthroughs, it is not yet possible to cure DR through pharmacotherapy. Cell death is thought to play a key role in the pathogenesis of DR. Moderate modulation of cellular autophagy and inhibition of apoptosis have been identified as effective targets for the treatment of DR. Numerous phytochemicals have emerged as potential new drugs for the treatment of DR. We collected basic DR research on herbal monomers through keywords such as autophagy and apoptosis, and conducted a systematic search for relevant research articles published in the PubMed database. This review provides the effects and reports of herbal monomers on various DR cellular and animal models in vivo and in vitro in the available literature, and emphasizes the importance of cellular autophagy and apoptosis as current DR therapeutic targets. Based on our review, we believe that herbal monomers that modulate autophagy and inhibit apoptosis may be potentially effective candidates for the development of new drugs in the treatment of DR. It provides a strategy for further development and application of herbal medicines for DR treatment.

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Section: Resultsmentioning

confidence: 99%

Exploring the protective effects of herbal monomers against diabetic retinopathy based on the regulation of autophagy and apoptosis: A review

Hu,

Wang,

et al. 2023

Medicine

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“…Our team proved that HSYA plays a protective role against MI/RI and cardiomyocyte hypoxia-reoxygenation (HR) injury [12,13]. Proven protective mechanisms mainly include inhibition of apoptosis, inflammation, mitochondrial dysfunction, and activation of autophagy [14,15]. For example, HSYA protects against HR injury via Akt/hexokinase II, independently of the ERK/GSK-3β pathway [16], and also displays a cardioprotective effect in vitro and in vivo via suppression of the JAK2/-STAT1 pathway [15].…”

Section: Introductionmentioning

confidence: 88%

Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Myocardial ischemia/reperfusion injury (MI/RI) is an urgent problem with a great impact on health globally. However, its pathological mechanisms have not been fully elucidated. Hydroxysafflor yellow A (HSYA) has a protective effect against MI/RI. This study is aimed at further clarifying the relationship between HSYA cardioprotection and calcium overload as well as the underlying mechanisms. We verified the protective effect of HSYA on neonatal rat primary cardiomyocytes (NPCMs) and human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from hypoxia-reoxygenation (HR) injury. To explore the cardioprotective mechanism of HSYA, we employed calcium fluorescence, TUNEL assay, JC-1 staining, and western blotting. Finally, cardio-ECR and patch-clamp experiments were used to explain the regulation of L-type calcium channels (LTCC) in cardioprotection mediated by HSYA. The results showed that HSYA reduced the levels of myocardial enzymes and protected NPCMs from HR injury. HSYA also restored the contractile function of hiPSC-CMs and field potential signal abnormalities caused by HR and exerted a protective effect on cardiac function. Further, we demonstrated that HSYA protects cardiomyocytes from HR injury by decreasing mitochondrial membrane potential and inhibiting apoptosis and calcium overload. Patch-clamp results revealed that MI/RI caused a sharp increase in calcium currents, which was inhibited by pretreatment with HSYA. Furthermore, we found that HSYA restored contraction amplitude, beat rate, and field potential duration of hiPSC-CMs, which were disrupted by the LTCC agonist Bay-K8644. Patch-clamp experiments also showed that HSYA inhibits Bay-K8644-induced calcium current, with an effect similar to that of the LTCC inhibitor nisoldipine. Therefore, our data suggest that HSYA targets LTCC to inhibit calcium overload and apoptosis of cardiomyocytes, thereby exerting a cardioprotective effect and reducing MI/RI injury.

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“…Yang et al [ 124 ] found that HSYA can increase Ca 2+ levels in endothelial cells through the TRPV4 channel and activate eNOS and its phosphorylation through protein kinase A, thus promoting NO production and leading to vascular relaxation. HSYA causes vasodilation mainly by the activation of the BKCa channel, inhibition of the L-type calcium channel, and reduction of intracellular free Ca 2+ levels [ 125 ]. As a Chinese herbal medicine, SY, the main active ingredient, can be used in the treatment of myocardial I/R injury.…”

Section: Clinical Applications Of Sy Pigmentmentioning

confidence: 99%

Pharmacological Activities of Safflower Yellow and Its Clinical Applications

Yan

Wen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Safflower is an annual herb used in traditional Chinese herbal medicine. It consists of the dried flowers of the Compositae plant safflower. It is found in the central inland areas of Asia and is widely cultivated throughout the country. Its resistance to cold weather and droughts and its tolerance and adaptability to salts and alkalis are strong. Safflower has the effect of activating blood circulation, dispersing blood stasis, and relieving pain. A natural pigment named safflower yellow (SY) can be extracted from safflower petals. Chemically, SY is a water-soluble flavonoid and the main active ingredient of safflower. The main chemical constituents, pharmacological properties, and clinical applications of SY are reviewed in this paper, thereby providing a reference for the use of safflower in preventing and treating human diseases. Methods. The literature published in recent years was reviewed, and the main chemical components of SY were identified based on chemical formula and structure. The pharmacological properties of hydroxysafflor yellow A (HSYA), SYA, SYB, and anhydrosafflor yellow B (AHSYB) were reviewed. Results. The main chemical constituents of SY included HSYA, SYA, SYB, and AHSYB. These ingredients have a wide range of pharmacological activities. SY has protective effects on the heart, kidneys, liver, nerves, lungs, and brain. Moreover, its effects include, but are not limited to, improving cardiovascular and cerebrovascular diseases, abirritation, regulating lipids, and treating cancer and diabetic complications. HSYA is widely recognised as an effective ingredient to treat cardiovascular and cerebrovascular diseases. Conclusion. SY has a wide range of pharmacological activities, among which improving cardiovascular and cerebrovascular diseases are the most significant.

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Hydroxysafflor yellow A actives BKCa channels and inhibits L-type Ca channels to induce vascular relaxation

Cited by 11 publications

References 38 publications

Exploring the protective effects of herbal monomers against diabetic retinopathy based on the regulation of autophagy and apoptosis: A review

Exploring the protective effects of herbal monomers against diabetic retinopathy based on the regulation of autophagy and apoptosis: A review

Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis

Pharmacological Activities of Safflower Yellow and Its Clinical Applications

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