Hydroxypropyl β-cyclodextrin nanohybrid monoliths for use in capillary electrochromatography with UV detection: application to the enantiomeric separation of adrenergic drugs, anticholinergic drugs, antidepressants, azoles, and antihistamine

Zhou, Li; Cai, Liangzhao; Lun, Jia; Zhao, Min; Guo, Xingjie

doi:10.1007/s00604-020-04317-4

Cited by 14 publications

(7 citation statements)

References 34 publications

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“…When the concentration of HP‐β‐CD was relatively low, there was not enough interaction between the chiral additive and the analytes so that the two enantiomers could not reach baseline separation. However, the relatively high concentration of HP‐β‐CD caused the molecular self‐assembly phenomenon and the resolutions decreased 37,38 . The final optimum concentration for chiral separation was 20‐mM HP‐β‐CD shown in Figure 8.…”

Section: Resultsmentioning

confidence: 99%

A covalent organic framework for chiral capillary electrochromatography using a cyclodextrin mobile phase additive

et al. 2022

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Covalent organic frameworks (COFs) have been recognized as promising solid phases in capillary electrochromatography (CEC). Imine-based COF-coated open-tubular CEC column (COF TpBD-coated OT column) was prepared and characterized by X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectra, thermogravimetric analysis (TGA), nitrogen adsorption/desorption (Brunauer-Emmett-Teller [BET]), and scanning electron microscopy (SEM). The results showed that the column efficiency was up to 26,776 plate/m, and the thickness of stationary phase was about 6.00 μm for the column prepared under the optimal conditions. Enantioseparation of 15 kinds of the single chiral compounds (histidine, arginine, lysine, leucine, threonine, methionine, valine, aspartic acid and glutamic acid, fipronil, diclofop, imazamox, quizalofop-p, imazethapyr, and acephate) and 3 kinds of mixed amino acids racemaces (valine, methionine, and glutamic acid) were performed with three methods: capillary electrochromatography with COF TpBD-coated OT column (Method 1), CEC with COF TpBD-coated OT column as the separation channels, and capillary electrophoresis (CE) with HP-β-CD as the chiral mobile phase additive (Method 2) and CE with HP-β-CD as the chiral mobile phase additive (Method 3). Separation efficiency and chiral selectivity of Method 2 was best among the three methods. Under the optimal separation conditions of Method 2, all the enantiomers reached the baseline separation regardless of the single chiral compounds or the mixed amino acids. Relative standard deviation (RSDs) of the mean column efficiency for reproducibility and stability was in the range of 0.46-1.49%. This combination of CEC and CE has great potential for use in chiral separation.

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Section: Resultsmentioning

confidence: 99%

A covalent organic framework for chiral capillary electrochromatography using a cyclodextrin mobile phase additive

et al. 2022

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“…The monomer glycidyl methacrylate‐bonded HP‐β‐CD (GMA‐HP‐β‐CD) and CDHM adsorbents were synthesized according to our previous work with a minor modification [29]. A solution of HP‐β‐CD (2 g), GMA (0.73 g) and 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (0.2 g) in DMSO (5 g) was stirred for 30 min at 100°C.…”

Section: Methodsmentioning

confidence: 99%

“…The monomer glycidyl methacrylate-bonded HP-β-CD (GMA-HP-β-CD) and CDHM adsorbents were synthesized according to our previous work with a minor modification [29]. A solution of HP-β-CD (2 g), GMA (0.73 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (0.2 g) in DMSO (5 g) was stirred for 30 min at 100 • C. The resulting yellow solution was poured into a large amount of toluene, the oil-like precipitate was washed carefully with toluene and diethyl ether several times, then dried under vacuum at 70 • C, GMA-HP-β-CD was finally obtained.…”

Section: Preparation Of Hp-β-cd Hybrid Monolith Materialsmentioning

confidence: 99%

Use of hydroxypropyl β‐cyclodextrin hybrid monolithic material as adsorbent for dispersive solid‐phase extraction of fluoroquinolones from environmental water samples

Zhou

2022

J of Separation Science

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In this study, the hydroxypropyl β-cyclodextrin hybrid monolithic material was fabricated and firstly applied as an adsorbent for dispersive solidphase extraction coupled with high-performance liquid chromatography to detect trace-level seven fluoroquinolones in water samples. The prepared hydroxypropyl β-cyclodextrin hybrid monolithic material was characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, and adsorption experiments, which showed excellent specific adsorption to the target fluoroquinolones. Under the optimized conditions, the extraction methodology showed satisfactory precision with relative standard deviations between 2.6% and 5.6%, good linearity (R 2 ≥ 0.9990), and satisfactory recoveries (82.5-91.8%).The limits of detection and limits of quantification of the method were in the range of 0.4-1.2 and 1.4-4.0 ng/mL, respectively, which confirmed the possibility of quantifying trace levels. Furthermore, the material could be reused at least five times. These results demonstrated that the hydroxypropyl β-cyclodextrin hybrid monolithic material was a promising adsorbent for fluoroquinolones, and the established method combined dispersive solid-phase extraction with highperformance liquid chromatography was suitable for the determination of fluoroquinolones in aqueous samples.

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“…Enantiomeric separation of adrenergic drugs, anticholinergic drugs, antidepressants, azoles, and antihistamine by hydroxypropyl beta-cyclodextrin nanohybrid monoliths was performed using capillary electrochromatography with UV detection. For tulobuterol, the most effective separation was obtained (N: 17 423, Rs:4.74) [44]. A metal-organic framework-functionalized monolithic column was fabricated by Ding et al and used for enantioseparation of six basic chiral drugs with CEC.…”

Section: Evaluation Of Electrochromatographic Separation Power and Comparison With Literaturementioning

confidence: 99%

S‐citalopram imprinted monolithic columns for capillary electrochromatography enantioseparations

et al. 2021

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In this study, the molecular imprinting method was used to separate enantiomeric forms of chiral antidepressant drug, R,S-citalopram (R,S-CIT) in aqueous solution by CEC system combining the advantages of capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC). For that, an amino acid-based molecularly imprinted monolithic capillary column was designed and used as a stationary phase for selective separation of S-citalopram (S-CIT) for the first time. S-CIT was selectively separated from the aqueous solution containing the other enantiomeric form of R-CIT, which is the same in size and shape as the template molecule. Morphology of the molecularly imprinted (MIP S-CIT) and non-imprinted (NIP S-CIT) monolithic capillary columns was observed by scanning electron microscopy. Imprinting efficiency of MIP S-CIT monolithic capillary column used for selective S-CIT separation was verified by comparing with NIP S-CIT and calculated imprinting factor (I.F:1.81) proved the high selectivity of the MIP S-CIT for S-CIT. Cavities formed for S-CIT form enabled selective (α = 2.08) separation of the target molecule from the other enantiomeric R-CIT form. Separation was achieved in a short period of 10 min, with the electrophoretic mobility of 7.68 × 10 −6 m 2 /Vs for R,S-CIT at pH 7.0 10 mM PB and 50% ACN ratio. The performance of both MIP S-CIT and NIP S-CIT columns was estimated by repeating the R,S-CIT separations with intra-batch and inter-batch studies for reproducibility of retention times of R,S-CITs. Estimated RSD values that are lower than 2% suggest that the monolithic columns separate R,S-CIT enantiomers without losing separation efficiency.

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Hydroxypropyl β-cyclodextrin nanohybrid monoliths for use in capillary electrochromatography with UV detection: application to the enantiomeric separation of adrenergic drugs, anticholinergic drugs, antidepressants, azoles, and antihistamine

Cited by 14 publications

References 34 publications

A covalent organic framework for chiral capillary electrochromatography using a cyclodextrin mobile phase additive

A covalent organic framework for chiral capillary electrochromatography using a cyclodextrin mobile phase additive

Use of hydroxypropyl β‐cyclodextrin hybrid monolithic material as adsorbent for dispersive solid‐phase extraction of fluoroquinolones from environmental water samples

S‐citalopram imprinted monolithic columns for capillary electrochromatography enantioseparations

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