Hydroxypropyl-β-Cyclodextrin Copolymers and Their Nanoparticles as Doxorubicin Delivery System

Wang, Tiewei; Zhang, Chunyu; Liang, Xing‐Jie; Liang, Wei; Wu, Yan

doi:10.1002/jps.22352

Cited by 24 publications

(8 citation statements)

References 34 publications

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“…In the same way, Wang and collaborators synthesized a novel biodegradable and amphiphilic copolymer composed of hydroxypropyl-β-cyclodextrin, polylactide, and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine. Nanoparticles from this copolymer loaded with doxorubicin demonstrated an antitumor activity against cancer HepG2 and A549 cells comparable to that observed with the free drug [112].…”

Section: Figuresupporting

confidence: 52%

Molecular Buckets: Cyclodextrins for Oral Cancer Therapy

Calleja

Huarte

Agüeros

et al. 2011

Therapeutic Delivery

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The oral route is preferred by patients for drug administration due to its convenience, resulting in improved compliance. Unfortunately, for a number of drugs (e.g., anticancer drugs), this route of administration remains a challenge. Oral chemotherapy may be an attractive option and especially appropriate for chronic treatment of cancer. However, this route of administration is particularly complicated for the administration of anticancer drugs ascribed to Class IV of the Biopharmaceutical Classification System. This group of compounds is characterized by low aqueous solubility and low intestinal permeability. This review focuses on the use of cyclodextrins alone or in combination with bioadhesive nanoparticles for oral delivery of drugs. The state-of-the-art technology and challenges in this area is also discussed.

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Section: Figuresupporting

confidence: 52%

Molecular Buckets: Cyclodextrins for Oral Cancer Therapy

Calleja

Huarte

Agüeros

et al. 2011

Therapeutic Delivery

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“…To combine the advantage of NPs and PAA as drug carriers and to overcome the inherent limitation of anti‐tumor drugs, novel PAA derivatives were synthesized by conjugating the 1,2‐dipalmitoyl‐ sn ‐glycero‐3‐phosphoethanolamine (DPPE) moiety onto the poly(AA‐co‐LA) co‐polymer. DPPE was chosen in our design because of its biological origin, which may lead to a better biocompatibility of the polymer 20. As it is well known, certain polyethylene glycol/phosphatidylethanolamine (PEG‐PE) polymer can form very stable micelles in aqueous media.…”

Section: Introductionmentioning

confidence: 99%

Efficient Delivery of Antitumor Drug to the Nuclei of Tumor Cells by Amphiphilic Biodegradable Poly(L‐Aspartic Acid‐co‐Lactic Acid)/DPPE Co‐Polymer Nanoparticles

Han

Liu

Nie

et al. 2012

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The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significant therapeutic potential. Polyaspartic acid and polylactic acid are the most intensively studied biodegradable polymers. In the present study, novel amphiphilic biodegradable co-polymer NPs, poly(L-aspartic acid-co-lactic acid) with 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) (poly(AA-co-LA)/DPPE) is synthesized and subsequently used to encapsulate an antitumor drug doxorubicin (DOX). The formulation parameters of the NPs are optimized to improve encapsulation efficiency. The resulting drug-loaded NPs possess better size homogeneity (polydispersity) and exhibit pH-responsive drug release profiles. Cellular viability assays indicate that the poly(AA-co-LA)/DPPE NPs did not induce cell death, whereas doxorubicin encapsulated NPs were cytotoxic to various types of tumor cells. In addition, the free NPs could not enter the cell nuclei after internalized in tumor cells. The DOX-loaded NPs exhibit efficient intracellular delivery in tumor cells with co-localization in lysosome and delay entering into the nucleus, which suggests a time- and pH-dependent drug release profile within cells. When applied to deliver chemotherapeutics to a mouse xenograft model of human lung adenocarcinoma, DOX-loaded NPs have a comparable antitumor activity with free DOX, and greatly reduce systemic toxicity and mortality. The delivery of cytotoxic drugs directly to the nucleus specifically within tumor cells is of great interest. These results demonstrate the feasibility of the application of the amphiphilic polyaspartic acid derivative, poly(AA-co-LA)/DPPE, as a nanocarrier for cell nuclear delivery of potent antitumor drugs.

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“…The introduction of 1,2-dipalmitoylsn-glycero-3-phosphoethanolamine (DPPE) moiety onto ␥-PGA-co-PLA copolymer can improve the performance of NPs [17]. It is known at present that DPPE, a phospholipid, the main constituent of the lipid bilayer of cell membrane, has both high biocompatibility and high flexibility [18].…”

Section: Introductionmentioning

confidence: 99%