Molecular Buckets: Cyclodextrins for Oral Cancer Therapy

Calleja, Patricia; Huarte, Judit; Agüeros, Maite; Ruiz-Gatón, Luisa; Espuelas, Socorro; Irache, Juan M.

doi:10.4155/tde.11.140

Cited by 17 publications

(6 citation statements)

References 125 publications

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“…The number of antineoplastic drugs administered orally is likely to continue growing. It is estimated that the percentage of oral anticancer drugs will increase to 25% by 2013, compared with 10% in 2008, and that 85% of these will be targeted therapies 20. The advent of oral chemotherapy drugs reflects the fact that the oral route is preferred by patients with cancer, as highlighted in a study conducted 13 years ago in which patients were asked whether they preferred to be treated at home with 4–5 pills per day for 5 days per month or with intravenous chemotherapy in the hospital 21.…”

Section: Discussionmentioning

confidence: 99%

Active home-based cancer treatment

Bordonaro¹,

Raiti²,

Anna³

et al. 2012

JMDH

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BackgroundActive home-based treatment represents a new model of health care. Chronic treatment requires continuous access to facilities that provide cancer care, with considerable effort, particularly economic, on the part of patients and caregivers. Oral chemotherapy could be limited as a consequence of poor compliance and adherence, especially by elderly patients.MethodsWe selected 30 cancer patients referred to our department and treated with oral therapy (capecitabine, vinorelbine, imatinib, sunitinib, sorafenib, temozolomide, ibandronate). This pilot study of oral therapy in the patient’s home was undertaken by a doctor and two nurses with experience in clinical oncology. The instruments used were clinical diaries recording home visits, hospital visits, need for caregiver support, and a questionnaire specially developed by the European Organization for Research and Treatment of Cancer (EORTC), known as the QLQ-C30 version 2.0, concerning the acceptability of oral treatment from the patient’s perspective.ResultsThis program decreased the need to access cancer facilities by 98.1%, promoted better quality of life for patients, as reflected in increased EORTC QLQ-C30 scores over time, allowing for greater adherence to oral treatment as a result of control of drug administration outside the hospital. This model has allowed treatment of patients with difficult access to care (elderly, disabled or otherwise needed caregivers) that in the project represent the majority (78% of these).ConclusionsThis model of active home care improves quality of life and adherence with oral therapy, reduces the need to visit the hospital, and consequently decreases the number of lost hours of work on the part of carers. Management of the service by the professionals involved revealed excellent control of the process by nursing staff, with minimal visits involving doctors.

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Section: Discussionmentioning

confidence: 99%

Active home-based cancer treatment

Bordonaro¹,

Raiti²,

Anna³

et al. 2012

JMDH

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“…13,14 These are explored for drug delivery through different routes of administration including oral, 15 pulmonary, 16 nasal, parenteral, 17 ocular, 18 brain 19 and dermal-transdermal routes. 20,21 The reports focused on cyclodextrin (CD) which discusses its role in oral cancer therapy, 22 pharmaceutical and biomedical applications of CD-based nanogels 23 and in drug and gene delivery are available. [24][25][26][27] Despite the varied potential of NPs, they possess lacuna related to some physicochemical and pharmaceutical aspects.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Gadade

Pekamwar

2020

Adv Pharm Bull

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Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. The CDs can cause intervention in aspects related to nanoparticles (NPs) that include improving drug loading in nano-system, improving stability, site-specific/targeted drug delivery, improving solubility profile and absorption of the drug in nanosystem with consequent improvement in bioavailability, with the possibility of controlled release, safety and efficacy. They find application in for simultaneous diagnosis and therapeutics for better treatment procedures. The current communication is focused on the application of CDs to overcome troubles in nanoparticulate formulation and enhancement of their performance. It also envisages the theranostic aspects of CDs.

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“…It is known that complexation of drugs with CDs provide an improvement in its dissolution rate and consequently in oral absorption [ 27 ]. Besides, CDs serve as a permeability enhancer upon oral administration which plays an important role for drugs having low intestinal permeability [ 28 – 29 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin

Ünal¹,

Öztürk²,

Bilensoy³

2015

Beilstein J. Org. Chem.

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Summary Background: The aim of this study was to design and evaluate hybrid cyclodextrin (CD) nanocapsules intended for the oral delivery of the anticancer agent camptothecin (CPT) in order to maintain drug stability in the body and to improve its eventual bioavailability. For this reason, an amphiphilic cyclodextrin (CD) derivative per-modified on the primary face 6OCAPRO was used as core molecule to form nanocapsules with the nanoprecipitation technique. Nanocapsules were further coated with the cationic polymer chitosan to improve the cellular uptake and interaction with biological membranes through positive surface charge. Nanocapsules were evaluated for their in vitro characteristics such as particle size, zeta potential, drug loading and release profiles followed by cell culture studies with the MCF-7 and Caco-2 cell line evaluating their anticancer efficacy and permeability. The CD nanocapsules were imaged by scanning electron microscopy (SEM). The concentration of CPT entrapped in nanocapsules was determined by reversed phase HPLC. The in vitro release study of CPT was performed with a dialysis bag method under sink conditions mimicking the gastric and intestinal pH. The hydrolytic stability of CPT in nanocapsules was investigated in simulated gastric and intestinal fluids (SGF, SIF). Results: The mean particle sizes of both anionic and cationic CPT-loaded nanocapsules were in the range of 180–200 nm with polydispersity indices lower than 0.400 indicating monodisperse size distribution of nanocapsules with favourable potential for intracellular drug delivery to tumour cells. Surface charges of anionic and cationic nanocapsules were demonstrated as −21 mV and +18 mV, respectively. The stability of CPT in simulated release media, SGF and SIF were maintained suggesting the improved protection of the drug molecule from rapid hydrolysis degradation or gastrointestinal pH in nanocapsule oily core. Furthermore CD nanocapsules showed higher anticancer efficacy than CPT solution against the MCF-7 cell line. Permeation of CPT across Caco-2 cells was found to be 3 fold higher when incorporated in hybrid CD nanocapsules compared with a DMSO solution. Conclusion: Oral CD nanocapsules indicating increased oral bioavailability might be a promising strategy to maintain the physiological stability and to improve the oral bioavailability of problematic anticancer drugs such as CPT which may contribute to patient quality of life and drug efficacy in cancer therapy.

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Molecular Buckets: Cyclodextrins for Oral Cancer Therapy

Cited by 17 publications

References 125 publications

Active home-based cancer treatment

Active home-based cancer treatment

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin

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