Hydroxypropyl methylcellulose (HPMC) formulated films: Relevance to adhesion and friction surface properties

Fahs, Ahmad; Brogly, Maurice; Bistac, Sophie; Schmitt, Marjorie

doi:10.1016/j.carbpol.2009.10.071

Cited by 66 publications

(44 citation statements)

References 36 publications

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“…It may be implied that the interaction between HPMC and PC molecules caused the reduction in surface free energy of blend films. Additionally, the conformation and surface molecular orientation of the both compounds may be effect on these results 6) and confirmed by using FTIR, XRD, SEM and AFM in further experiment.…”

Section: Resultssupporting

confidence: 57%

“…2,4,5) Hydroxypropylmethyl cellulose (HPMC) is one of the most general hydrophilic polymers, which is extensively used in many fields owing to its ease of use, excellent film-forming ability, good biocompatibility and biodegradability. 6,7) In addition, HPMC has been displayed to possess hydrogel-forming properties, which are essential for mucoadhesion, and it also has rapid swelling due to high water absorbing capacity, including displaying moderate mucoadhesive properties as well. 4,8) Hence, HPMC is a popular hydrophilic polymer used in the formulation of mucoadhesive films.…”

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confidence: 99%

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Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

et al. 2017

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The objectives of this study were to prepare the hydroxypropyl methylcellulose (HPMC)/polycarbophil (PC) mucoadhesive blend film and to investigate the main and interaction effect of HPMC and PC mixtures on the physicochemical and mechanical properties of blend films using a simplex lattice mixture design approach. The cubic and quadratic models were selected to analyze mucoadhesive properties in terms of work of adhesion and maximum detachment force, respectively. It was shown that HPMC/PC blend film had higher mucoadhesive properties than pure HPMC film. The suitable models for analyzing swelling index of blend films at various times were assessed. The puncture strength, % elongation and hydrophilicity of films were also examined. The pure HPMC film displayed more homogeneous and smoother structures compared with the blend film, as observed by scanning electron microscope and atomic force microscopy. Intermolecular hydrogen bonding between HPMC and PC was detected using Fourier transform infrared and X-ray diffraction. Therefore, the blend film shows high potential for use as a buccal delivery system. Key words hydroxypropyl methylcellulose (HPMC); polycarbophil; blend film; mixture design; mucoadhesive film; buccal drug delivery Buccal drug delivery systems have several advantages such as good accessibility, avoiding hepatic first pass metabolism and drug degradation in the gastrointestinal tract.

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Section: Resultssupporting

confidence: 57%

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confidence: 99%

Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

et al. 2017

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“…In the past recent years, significant progress has been made on the development of biodegradable polymers for several key applications [1][2][3][4][5] such as packaging films, coatings, agriculture, and pharmaceutical materials as the production and the use of non-biodegradable plastics in the world have been enormously increased resulting in general shortage of landfill availability, and worsening the problems of the waste disposal. The increasing awareness for environmental conservation and protection has promoted the development of plastics that should degrade more rapidly in the environment, leading to a complete mineralization or bioassimilation of the plastics [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Gamma Radiation Crosslinking and Chemical Crosslinking on Properties of Methylcellulose Hydrogel

Rimdusit¹,

Somsaeng²,

Kewsuwan³

et al. 2012

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Abstract. In this research, characteristics of methylcellulose (MC) films modified with two crosslinking methods are investigated. The first method is the use of a glutaraldehyde (GA) crosslinker to promote hemi-acetal linkages between MC chains. The second one is gamma irradiation to form insoluble MC gel by intermolecular crosslinking. The effects of the MC concentration on the degree of crosslinking, water absorption, gel content, degree of swelling, and thermomechanical properties were determined. The results indicate that the chemically crosslinked MC films show lower polarity than the radiation crosslinked films. The nature of the crosslinkings was also revealed with FTIR spectra. The waterswelled films of chemically crosslinked MC were found to provide homogeneous gel structure whereas the radiation crosslinked MC films were observed to render less uniform crosslinked films.

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“…HPMC is a cellulosic derived that is moisturized quickly, but swells and takes longer to disintegrate in body temperature; it is also more soluble in lower temperatures, such as 10 ºC. 18,19 The gelatin is a soluble protein in hot water and in the gastric liquid, where it quickly releases its contents soluble in biological fluids at a room temperature. 3 Capsules of the reference medicine showed higher values for the test compared the disintegration of gelatin capsules, probably due to compression existing in the process of industrial scale production.…”

Section: Quality Control For Pharmaceutical Dosage Formmentioning

confidence: 99%

Evaluation of hard gelatin capsules and hydroxypropyl methylcellulose containing ampicillin

Weigert¹,

Ineu²,

Gomes³

2012

Quím. Nova

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Recebido em 23/1/11; aceito em 1/7/11; publicado na web em 9/8/11This study aims to develop and evaluate formulations containing ampicillin in capsules of gelatin and hydroxypropyl methylcellulose (HPMC). Two formulations (A and B) were developed. The final product quality was evaluated by testing for quality control and the results were in agreement with the Brazilian Pharmacopoeia. The formulations with HPMC capsules showed lower percentages of drug dissolved (99.67%, HPMC-A and 87.70%, HPMC-B) than the gelatin (100.18%, GEL-A and 101.16% GEL-B). Because of the delay of the ampicillin release observed in the dissolution profiles, it becomes necessary to evaluate the drugs that can be conditioned in the HPMC capsules.

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Hydroxypropyl methylcellulose (HPMC) formulated films: Relevance to adhesion and friction surface properties

Cited by 66 publications

References 36 publications

Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

Comparison of Gamma Radiation Crosslinking and Chemical Crosslinking on Properties of Methylcellulose Hydrogel

Evaluation of hard gelatin capsules and hydroxypropyl methylcellulose containing ampicillin

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