Hydroxyl‐Rich Polycation Brushed Multifunctional Rare‐Earth‐Gold Core–Shell Nanorods for Versatile Therapy Platforms

Abstract

It is of great significance to develop a multifunctional imaging-guided therapeutic platform with ideal resolution and sensitivity. Notably, rare-earth (RE) nanoparticles are attractive candidates for multimodal imaging due to their unique optical and magnetic properties. In this work, a rational design of hierarchical nanohybrids employing RE-Au hetero-nanostructures is proposed. 1D RE nanorods are adopted as the core to facilitate cellular internalization with the coating of gold nanoshells for photothermal performances. Hydroxyl-rich polycations with low cytotoxicity are grafted onto the surface of RE-Au to produce RE-Au-PGEA (ethanolamine-functionalized poly(glycidyl methacrylate)) nanohybrids with impressive gene transfection capability. Given the virtues of all the components, the feasibility of RE-Au-PGEA for multifunctional photoacoustic, computed tomography, magnetic resonance, upconversion luminescence imaging, and complementary photothermal therapy/gene therapy therapy is investigated in detail in vitro and in vivo. The visualization of the therapeutic processes with comprehensive information renders RE-Au-PGEA nanohybrid an intriguing platform to realize enhanced antitumor efficiency.

Smart Delivery Systems Based on Poly(glycidyl methacrylate)s‐Coated Organic/Inorganic Core–Shell Nanohybrids

“…Xu and Zhao et al integrated virtues of 1D RE NRs (Gd 2 O 3 :Yb 3+ , Er 3+ ) for cellular internalization and CT/MR/UCL imaging, Au nanoshells for PTT and PA/CT imaging, and PGEAs for impressive gene transfection in one hetero-nanostructure (Figure 13). [68] RE-Au core-shell nanorods were obtained by growing gold nanoshells in situ on the surface of RE@SO 2. Owing to the interactions of Au and disulfide bonds, disulfide-linked PGEAs were grafted onto the surface of RE-Au nanoparticles.…”

“…Schematic illustration of the preparation processes of RE-Au-PGEA nanohybrids for multifunctional therapy platforms, and TEM images of RE, RE@SiO 2 , and RE-Au nanorods. Reproduced with permission [68]. Copyright 2017, Wiley-VCH.www.advancedsciencenews.com www.mrc-journal.de Macromol.…”

CRISPR/Cas9 Delivery Mediated with Hydroxyl‐Rich Nanosystems for Gene Editing in Aorta

“…[24][25][26] Such hydroxylrich gene vector has great potential for the treatment of heart disease and tumors. [24][25][26] Such hydroxylrich gene vector has great potential for the treatment of heart disease and tumors.…”

Self-destructible polysaccharide nanocomposites with unlockable Au nanorods for high-performance photothermal therapy

“…As one of the most appealing strategies, PTT through the conversion of nearinfrared (NIR) light into heat possesses the advantage of negligible damage to normal cells [5][6][7] . NIR light-absorbing plasmonic nanoparticles have been successfully employed for effective PTT, and most of these nanoparticles exploit passive targeting by the enhanced permeation and retention (EPR) effect [8][9][10][11] . Surface ligands for active cell targeting could further facilitate the preferential accumulation of nanomaterials [12][13][14] .…”