Hydroxyhydroquinone-free coffee: A double-blind, randomized controlled dose–response study of blood pressure

Yamaguchi, Tohru; Chikama, Akiro; Mori, Kensaku; Watanabe, Takatomo; Shioya, Yasushi; Katsuragi, Yoshihisa; Tokimitsu, Ichiro

doi:10.1016/j.numecd.2007.03.004

Cited by 88 publications

(72 citation statements)

References 16 publications

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“…16 In addition, co-administration of 3 mg kg -1 HHQ along with HHQ-free coffee abolished the antihypertensive effect of HHQ-free coffee. In volunteer patients with mild hypertension who were not taking anti-hypertensive medication, 32 a combination treatment of 299 mg of CGA and 1.7 mg of HHQ had no effect on their BP. Consistent with the animal studies, after daily consumption of HHQ-free coffee (containing 82 to 299 mg per day of CGA and no more than 0.05 mg per day of HHQ) for 4 weeks, the BP were decreased in a marginally dose-dependent pattern.…”

Section: Different Roles Of Coffee Components In Blood-pressure Regulmentioning

confidence: 91%

“…Consistent with the animal studies, after daily consumption of HHQ-free coffee (containing 82 to 299 mg per day of CGA and no more than 0.05 mg per day of HHQ) for 4 weeks, the BP were decreased in a marginally dose-dependent pattern. 32 The fact that in the presence of HHQ, GCE, CGAs and coffee no longer had any significant antihypertensive effect implicated that HHQ was the culprit in counteracting the anti-hypertensive effect of CGAs in regular coffee.…”

Section: Different Roles Of Coffee Components In Blood-pressure Regulmentioning

confidence: 99%

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Antihypertensive effects and mechanisms of chlorogenic acids

et al. 2011

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Chlorogenic acids (CGAs) are potent antioxidants found in certain foods and drinks, most notably in coffee. In recent years, basic and clinical investigations have implied that the consumption of chlorogenic acid can have an anti-hypertension effect. Mechanistically, the metabolites of CGAs attenuate oxidative stress (reactive oxygen species), which leads to the benefit of blood-pressure reduction through improved endothelial function and nitric oxide bioavailability in the arterial vasculature. This review article highlights the physiological and biochemical findings on this subject and highlights some remaining issues that merit further scientific and clinical exploration. In the framework of lifestyle modification for the management of cardiovascular risk factors, the dietary consumption of CGAs may hold promise for providing a non-pharmacological approach for the prevention and treatment of high blood pressure.

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Section: Different Roles Of Coffee Components In Blood-pressure Regulmentioning

confidence: 91%

Section: Different Roles Of Coffee Components In Blood-pressure Regulmentioning

confidence: 99%

Antihypertensive effects and mechanisms of chlorogenic acids

et al. 2011

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“…Cocoa may also improve insulin resistance and endothelial function [276,279,281] . Polyphenols, chlorogenic acids (CGAs), the ferulic acid metabolite of CGAs and di-hydro-caffeic acids decrease BP in a dose dependent manner, increase eNOS and improve endothelial function in humans [284][285][286] . CGAs in green coffee been extract at doses of 140 mg/d significantly reduced SBP and DBP in 28 subjects in a placebocontrolled randomized clinical trial.…”

Section: Sesamementioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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“…It has also been shown that hydroxyhydroquinone increased the production of reactive oxygen species in a dose-dependent manner [30]. Some clinical studies have shown that coffee with a high content of chlorogenic acids and a low content of hydroxyhydroquinone is effective for reducing blood pressure [31,32].…”

Section: Introductionmentioning

confidence: 99%

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

et al. 2018

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Purpose The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction. Methods This was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized to two study groups. The participants consumed a test meal with a single intake of the test coffee. Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. Subjects in the Study 2 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover. Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake. Results Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels. Conclusions These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction.

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Hydroxyhydroquinone-free coffee: A double-blind, randomized controlled dose–response study of blood pressure

Cited by 88 publications

References 16 publications

Antihypertensive effects and mechanisms of chlorogenic acids

Antihypertensive effects and mechanisms of chlorogenic acids

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

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