Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca 2+ concentration in rat thymic lymphocytes

Kamae, Risa; Nojima, Shoko; Akiyoshi, Kenji; Setsu, Shoki; Honda, Sari; Masuda, Toshiya; Oyama, Yasuo

doi:10.1016/j.fct.2017.01.025

Cited by 6 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the first stage, the amavadin-ion, containing tetravalent vanadium form in the reduced state will be transformed to the oxidized pentavalent form. Ama*(Red) -e - Ama (Ox) (2) Considering that the polymerization scenarios may require specific conditions, we conclude that the phenolic compounds will be oxidized according to the Fig. 4: The modeling, including (co)polymerization scenarios will be described in our next works.…”

Section: Methodsmentioning

confidence: 93%

The Theoretical Description for Fructose Fermentation Product Hydroxyquinol and its Ether Sesamol Amperometric Determination in Tahini Halva and Lokum

Volodymyr Tkach,

Kushnir,

Korniienko

et al. 2023

Orbital: Electron. J. Chem.

View full text Add to dashboard Cite

For the first time, hydroxyquinol and sesamol electrochemical amperometric determination in tahini halva and lokum Turkish delights has been described. The electroanalytical process is given by amavadin-modified conducting polymer, in which both monomer and dopant may be natural compounds. Taking into account the ionic nature of the modifier, even in neutral medium the oscillatory behavior will be more probable in this system than in the simplest cases. Nevertheless, the amavadin-modified conducting polymer may be efficient electrode modifier for hydroxyquinol and sesamol electrochemical determination in Turkish delights like lokum and tahini halva.

show abstract

Section: Methodsmentioning

confidence: 93%

The Theoretical Description for Fructose Fermentation Product Hydroxyquinol and its Ether Sesamol Amperometric Determination in Tahini Halva and Lokum

Volodymyr Tkach,

Kushnir,

Korniienko

et al. 2023

Orbital: Electron. J. Chem.

View full text Add to dashboard Cite

show abstract

“…It has been reported that reducing the amount of HHQ in coffee promotes the postprandial fat oxidation effect of CPP [23]. Furthermore, the effects of HHQ in rat thymocytes and thymic lymphocytes have been investigated [24,25]. Lower HHQ concentrations may decrease the risk of oxidative injury.…”

Section: Discussionmentioning

confidence: 99%

DNA Mutagenicity of Hydroxyhydroquinone in Roasted Coffee Products and Its Suppression by Chlorogenic Acid, a Coffee Polyphenol, in Oxidative-Damage-Sensitive SAMP8 Mice

Unno,

Taguchi,

Hase

et al. 2024

IJMS

View full text Add to dashboard Cite

Hydroxyhydroquinone (HHQ) is an oxidative component produced by roasting coffee beans and has been reported to generate relatively large amounts of reactive oxygen species (ROS). In this study, we used senescence-accelerated mouse prone 8 (SAMP8) mice to determine whether HHQ consumption increases oxidative-stress-induced injury, because in SAMP8 mice, the activity of 8-oxoguanine DNA glycosylase 1, which repairs oxidative modifications in DNA, is decreased. The results showed that two out of twelve (16.7%) HHQ-treated mice presented polyuria and glucosuria around 2 months after the start of treatment, indicating that HHQ may act as a mutagen against SAMP8 mice, which is sensitive to oxidative damage. No abnormalities were observed in the chlorogenic acid (coffee polyphenol, CPP)-treated group. The concentration of hydrogen peroxide in the serum of SAMP8 mice was significantly higher than that in SAMR1 (senescence-resistant) control mice, and the concentration was further increased in the HHQ-treated group. CPP, when coexisting with HHQ at the rate contained in roasted coffee, decreased the amount of hydrogen peroxide in the serum of SAMP8 mice. Although CPP can act both oxidatively and antioxidatively as a polyphenol, CPP acts more antioxidatively when coexisting with HHQ. Thus, the oxidative effect of HHQ was shown to be counteracted by CPP.

show abstract

“…The MDI-induced change in cell granularity was not associated with any changes in cell volume, as determined by forward scatter signal intensities, a parameter for cell size. The correlation between side scatter signal intensity and cytotoxic action has not been elucidated, although some cytotoxic substances have been reported to significantly augment side scatter (Kamae et al, 2017;Imai et al, 2017;Mitani et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Cytometric analysis on cytotoxicity of 4,4′-methylenediphenyl diisocyanate, a chemical allergen, in rat thymocytes

Oyama

Miyoshi

Oyama

2017

Fundam. Toxicol. Sci.

Self Cite

View full text Add to dashboard Cite

-4,4'-Methylenediphenyl diisocyanate (MDI) is a cross-linking agent. Chemical reactivity of MDI with endogenous substances such as albumin and glutathione (GSH) is assumed to be responsible for MDI toxicity. We examined the cytotoxic effect of MDI on rat thymocytes, under the condition that endogenous biological substances except for cells were nominally absent, in order to study chemico-biological interactions between MDI and cells. The treatment of 10-50 μM MDI for 3 hr significantly increased the side scatter signal intensity of cytograms, without affecting forward scatter intensity. The increase in side scatter signal intensity by MDI was associated with an increase in cell lethality. The treatment of cells with 50 μM MDI for 3 hr increased cell lethality without increasing the population of preapoptotic annexin V-positive living cells. In contrast, H 2 O 2 at 100 μM significantly increased the population of annexin V positive living cells prior to cell death. MDI at 30-50 μM did not affect the increase in cell lethality induced by H 2 O 2 or A23187. Simultaneous application of 50 μM GSH did not affect the cytotoxicity of 50 μM MDI. It was therefore concluded that the process of cell death induced by MDI could not be attributed to oxidative stress and intracellular Ca 2+ overload, and that MDI possesses cytotoxic actions that are not significantly related to its chemical reactivity with GSH.

show abstract

Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca 2+ concentration in rat thymic lymphocytes

Cited by 6 publications

References 22 publications

The Theoretical Description for Fructose Fermentation Product Hydroxyquinol and its Ether Sesamol Amperometric Determination in Tahini Halva and Lokum

The Theoretical Description for Fructose Fermentation Product Hydroxyquinol and its Ether Sesamol Amperometric Determination in Tahini Halva and Lokum

DNA Mutagenicity of Hydroxyhydroquinone in Roasted Coffee Products and Its Suppression by Chlorogenic Acid, a Coffee Polyphenol, in Oxidative-Damage-Sensitive SAMP8 Mice

Cytometric analysis on cytotoxicity of 4,4′-methylenediphenyl diisocyanate, a chemical allergen, in rat thymocytes

Contact Info

Product

Resources

About